公开(公告)号：US20230090293A1

公开(公告)日：2023-03-23

申请号：US17909197

申请日：2021-02-24

Applicant: ASTON UNIVERSITY

Inventor： Jonathan COX ,  Nicolas BARRY ,  James HARRISON ,  Victoria NOLAN ,  Anaïs PITTO-BARRY ,  Joan SOLDEVILA-BARREDA

IPC: A61K31/7135 ,  A61K9/20 ,  A61K9/00 ,  A61K9/12 ,  A61P31/04

Abstract: The invention provides a compound of Formula (I) or a pharmaceutically acceptable salt; wherein L is a substituted or non-substituted aromatic ligand; Z is a halogen or coordinating ligand; M is a group 8 or group 9 transition metal selected from; Fe, Ru, Os, Co, Rh and Os; A and B are independently selected from a substituted or non-substituted indole or pyridine, may be the same or different and coordinate to the transition metal M through the nitrogen atom of the indole or pyridine. The compounds have been shown to have use against antibiotic-resistant bacteria. A further aspect of the invention is directed towards treating or preventing bacterial infections.