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公开(公告)号：US20170115202A1
公开(公告)日：2017-04-27
申请号：US15348817
申请日：2016-11-10
Applicant: Abbott Laboratories
Inventor： John F. Heanue , Stuart L. Friedman
CPC classification number: G01N15/1434 , G01N15/1459 , G01N2015/1006 , G01N2201/068 , G02B27/0927 , G02B27/0966
Abstract: In some aspects, a flow cytometer system is provided that includes beam shaping optics positioned to manipulate a light beam and produce a resulting light beam that irradiates the core stream at the interrogation zone of the flow cell. The beam shaping optics include an acylindrical lens positioned to receive and focus light in a direction of a first axis orthogonal to a direction of light travel, and a cylindrical lens positioned to receive the light output from the acylindrical lens and to focus the light output from the acylindrical lens in a direction of a second axis orthogonal to the first axis and to the direction of light travel. The resulting light beam output has a flat-top shaped intensity profile along the first axis, and a Gaussian-shaped intensity profile along the second axis. Related methods of shaping a light beam at an interrogation zone of a flow cell are also provided.
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公开(公告)号：US20210131943A1
公开(公告)日：2021-05-06
申请号：US16994184
申请日：2020-08-14
Applicant: Abbott Laboratories
Inventor： John F. Heanue , Stuart L. Friedman
Abstract: In some aspects, a flow cytometer system is provided that includes beam shaping optics positioned to manipulate a light beam and produce a resulting light beam that irradiates the core stream at the interrogation zone of the flow cell. The beam shaping optics include an acylindrical lens positioned to receive and focus light in a direction of a first axis orthogonal to a direction of light travel, and a cylindrical lens positioned to receive the light output from the acylindrical lens and to focus the light output from the acylindrical lens in a direction of a second axis orthogonal to the first axis and to the direction of light travel. The resulting light beam output has a flat-top shaped intensity profile along the first axis, and a Gaussian-shaped intensity profile along the second axis. Related methods of shaping a light beam at an interrogation zone of a flow cell are also provided.
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公开(公告)号：US10274413B2
公开(公告)日：2019-04-30
申请号：US15348817
申请日：2016-11-10
Applicant: Abbott Laboratories
Inventor： John F. Heanue , Stuart L. Friedman
Abstract: In some aspects, a flow cytometer system is provided that includes beam shaping optics positioned to manipulate a light beam and produce a resulting light beam that irradiates the core stream at the interrogation zone of the flow cell. The beam shaping optics include an acylindrical lens positioned to receive and focus light in a direction of a first axis orthogonal to a direction of light travel, and a cylindrical lens positioned to receive the light output from the acylindrical lens and to focus the light output from the acylindrical lens in a direction of a second axis orthogonal to the first axis and to the direction of light travel. The resulting light beam output has a flat-top shaped intensity profile along the first axis, and a Gaussian-shaped intensity profile along the second axis. Related methods of shaping a light beam at an interrogation zone of a flow cell are also provided.
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4.发明授权公开(公告)号：US09523857B2
公开(公告)日：2016-12-20
申请号：US14212185
申请日：2014-03-14
Applicant: Abbott Laboratories
Inventor： John F. Heanue , Stuart L. Friedman
CPC classification number: G01N15/1434 , G01N15/1459 , G01N2015/1006 , G01N2201/068 , G02B27/0927 , G02B27/0966
Abstract: In some aspects, a flow cytometer system is provided that includes beam shaping optics positioned to manipulate a light beam and produce a resulting light beam that irradiates the core stream at the interrogation zone of the flow cell. The beam shaping optics include an acylindrical lens positioned to receive and focus light in a direction of a first axis orthogonal to a direction of light travel, and a cylindrical lens positioned to receive the light output from the acylindrical lens and to focus the light output from the acylindrical lens in a direction of a second axis orthogonal to the first axis and to the direction of light travel. The resulting light beam output has a flat-top shaped intensity profile along the first axis, and a Gaussian-shaped intensity profile along the second axis. Related methods of shaping a light beam at an interrogation zone of a flow cell are also provided.
Abstract translation: 在一些方面，提供流式细胞仪系统，其包括光束整形光学器件，其定位成操纵光束并产生在流动池的询问区域照射核心流的所得光束。 光束整形光学元件包括一个定位成在与光行进方向垂直的第一轴的方向上接收和聚焦光的圆柱形透镜，以及定位成接收从圆柱透镜输出的光并将来自 该圆柱形透镜在与第一轴正交的第二轴方向和光行进方向上。 所得到的光束输出具有沿着第一轴的平顶形强度分布，以及沿着第二轴的高斯形强度分布。 还提供了在流动池的询问区处对光束进行成形的相关方法。
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Patent Agency Ranking
公开(公告)号：US09494801B2
公开(公告)日：2016-11-15
申请号：US14212185
申请日：2014-03-14
Applicant: Abbott Laboratories
Inventor： John F. Heanue , Stuart L. Friedman
Abstract: In some aspects, a flow cytometer system is provided that includes beam shaping optics positioned to manipulate a light beam and produce a resulting light beam that irradiates the core stream at the interrogation zone of the flow cell. The beam shaping optics include an acylindrical lens positioned to receive and focus light in a direction of a first axis orthogonal to a direction of light travel, and a cylindrical lens positioned to receive the light output from the acylindrical lens and to focus the light output from the acylindrical lens in a direction of a second axis orthogonal to the first axis and to the direction of light travel. The resulting light beam output has a flat-top shaped intensity profile along the first axis, and a Gaussian-shaped intensity profile along the second axis. Related methods of shaping a light beam at an interrogation zone of a flow cell are also provided.
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公开(公告)号：US11262288B2
公开(公告)日：2022-03-01
申请号：US16994184
申请日：2020-08-14
Applicant: Abbott Laboratories
Inventor： John F. Heanue , Stuart L. Friedman
Abstract: In some aspects, a flow cytometer system is provided that includes beam shaping optics positioned to manipulate a light beam and produce a resulting light beam that irradiates the core stream at the interrogation zone of the flow cell. The beam shaping optics include an acylindrical lens positioned to receive and focus light in a direction of a first axis orthogonal to a direction of light travel, and a cylindrical lens positioned to receive the light output from the acylindrical lens and to focus the light output from the acylindrical lens in a direction of a second axis orthogonal to the first axis and to the direction of light travel. The resulting light beam output has a flat-top shaped intensity profile along the first axis, and a Gaussian-shaped intensity profile along the second axis. Related methods of shaping a light beam at an interrogation zone of a flow cell are also provided.
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公开(公告)号：US10830686B2
公开(公告)日：2020-11-10
申请号：US16363913
申请日：2019-03-25
Applicant: Abbott Laboratories
Inventor： John F. Heanue , Stuart L. Friedman
Abstract: In some aspects, a flow cytometer system is provided that includes beam shaping optics positioned to manipulate a light beam and produce a resulting light beam that irradiates the core stream at the interrogation zone of the flow cell. The beam shaping optics include an acylindrical lens positioned to receive and focus light in a direction of a first axis orthogonal to a direction of light travel, and a cylindrical lens positioned to receive the light output from the acylindrical lens and to focus the light output from the acylindrical lens in a direction of a second axis orthogonal to the first axis and to the direction of light travel. The resulting light beam output has a flat-top shaped intensity profile along the first axis, and a Gaussian-shaped intensity profile along the second axis. Related methods of shaping a light beam at an interrogation zone of a flow cell are also provided.
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公开(公告)号：US20190310180A1
公开(公告)日：2019-10-10
申请号：US16363913
申请日：2019-03-25
Applicant: Abbott Laboratories
Inventor： John F. Heanue , Stuart L. Friedman
Abstract: In some aspects, a flow cytometer system is provided that includes beam shaping optics positioned to manipulate a light beam and produce a resulting light beam that irradiates the core stream at the interrogation zone of the flow cell. The beam shaping optics include an acylindrical lens positioned to receive and focus light in a direction of a first axis orthogonal to a direction of light travel, and a cylindrical lens positioned to receive the light output from the acylindrical lens and to focus the light output from the acylindrical lens in a direction of a second axis orthogonal to the first axis and to the direction of light travel. The resulting light beam output has a flat-top shaped intensity profile along the first axis, and a Gaussian-shaped intensity profile along the second axis. Related methods of shaping a light beam at an interrogation zone of a flow cell are also provided.
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9.发明申请公开(公告)号：US20140264097A1
公开(公告)日：2014-09-18
申请号：US14212185
申请日：2014-03-14
Applicant: Abbott Laboratories
Inventor： John F. Heanue , Stuart L. Friedman
CPC classification number: G01N15/1434 , G01N15/1459 , G01N2015/1006 , G01N2201/068 , G02B27/0927 , G02B27/0966
Abstract: In some aspects, a flow cytometer system is provided that includes beam shaping optics positioned to manipulate a light beam and produce a resulting light beam that irradiates the core stream at the interrogation zone of the flow cell. The beam shaping optics include an acylindrical lens positioned to receive and focus light in a direction of a first axis orthogonal to a direction of light travel, and a cylindrical lens positioned to receive the light output from the acylindrical lens and to focus the light output from the acylindrical lens in a direction of a second axis orthogonal to the first axis and to the direction of light travel. The resulting light beam output has a flat-top shaped intensity profile along the first axis, and a Gaussian-shaped intensity profile along the second axis. Related methods of shaping a light beam at an interrogation zone of a flow cell are also provided.
Abstract translation: 在一些方面，提供流式细胞仪系统，其包括光束整形光学器件，其定位成操纵光束并产生在流动池的询问区域照射核心流的所得光束。 光束整形光学元件包括一个定位成在与光行进方向垂直的第一轴的方向上接收和聚焦光的圆柱形透镜，以及定位成接收从圆柱形透镜输出的光并将来自 该圆柱形透镜在与第一轴正交的第二轴方向和光行进方向上。 所得到的光束输出具有沿着第一轴的平顶形强度分布，以及沿着第二轴的高斯形强度分布。 还提供了在流动池的询问区处对光束进行成形的相关方法。
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