公开(公告)号：US20230302453A1

公开(公告)日：2023-09-28

申请号：US18306072

申请日：2023-04-24

Applicant: ABBOTT LABORATORIES

Inventor： Jeffrey B. Huff ,  Mark A. Hayden ,  Peter J. Karabatsos ,  Andrew Fischer ,  John M. Robinson ,  Shelley R. Holets-McCormack ,  Sophie Laurenson

IPC: G01N33/53 ,  B01L3/00 ,  G01N33/543

CPC classification number: B01L3/502784 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502761 ,  G01N33/5302 ,  G01N33/54373 ,  B01L2200/0668 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/142 ,  B01L2300/0829 ,  B01L2300/0858 ,  B01L2300/0887 ,  B01L2300/089 ,  B01L2300/0893 ,  B01L2300/12 ,  B01L2300/161 ,  B01L2400/0427

Abstract: Integrated devices that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells.

公开(公告)号：US20180104694A1

公开(公告)日：2018-04-19

申请号：US15724203

申请日：2017-10-03

Applicant: ABBOTT LABORATORIES

Inventor： Jeffrey B. Huff ,  Mark A. Hayden ,  Peter J. Karabatsos ,  Andrew Fischer ,  John M. Robinson ,  Shelley R. Holets-McCormack ,  Sophie Laurenson

IPC: B01L3/00 ,  G01N33/53

CPC classification number: B01L3/502784 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502761 ,  B01L2200/0668 ,  B01L2200/0689 ,  B01L2200/10 ,  B01L2200/142 ,  B01L2300/0829 ,  B01L2300/0858 ,  B01L2300/0887 ,  B01L2300/089 ,  B01L2300/0893 ,  B01L2300/12 ,  B01L2300/161 ,  G01N33/5302 ,  G01N33/54373

Abstract: Integrated devices that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells.

公开(公告)号：US20180095067A1

公开(公告)日：2018-04-05

申请号：US15724200

申请日：2017-10-03

Applicant: Abbott Laboratories

Inventor： Jeffrey B. Huff ,  Mark A. Hayden ,  Peter J. Karabatsos ,  Andrew S. Schapals ,  Anthony S. Muerhoff ,  Felicia Bogdan ,  Thomas Leary ,  Shelley R. Holets-McCormack ,  Sophie Laurenson ,  Andrew T. Fischer ,  Richard Haack ,  Stefan Hershberger ,  Dustin House ,  Lei QIAO ,  M. Shawn Murphy ,  Mark R. Pope ,  Edna M. Prieto-Ballengee ,  QiaoQiao Ruan ,  Pathik Soni ,  Sergey Tetin ,  Lyle Yarnell ,  John M. Robinson

IPC: G01N33/487 ,  G01N33/53

CPC classification number: G01N33/48721 ,  G01N33/5302 ,  G01N33/54326 ,  G01N33/5438

Abstract: Integrated microfluidic and analyte detection devices are disclosed, along with methods of detecting target analytes. Digital microfluidic and analyte detection devices include a first substrate and a second substrate aligned generally parallel to each other to define a gap therebetween, the first substrate including a plurality of electrodes to generate electrical actuation forces on a liquid droplet disposed in the gap; at least one reagent disposed on at least one of the first substrate or the second substrate and configured to be carried by the liquid droplet; and an analyte detection device in fluid communication with the gap, wherein the plurality of electrodes are configured to move the liquid droplet towards the analyte detection device.

公开(公告)号：US11633738B2

公开(公告)日：2023-04-25

申请号：US15724203

申请日：2017-10-03

Applicant: ABBOTT LABORATORIES

Inventor： Jeffrey B. Huff ,  Mark A. Hayden ,  Peter J. Karabatsos ,  Andrew Fischer ,  John M. Robinson ,  Shelley R. Holets-McCormack ,  Sophie Laurenson

IPC: B01L3/00 ,  G01N33/543 ,  G01N33/53

Abstract: Integrated devices that include a sample preparation component integrated with a detection component are disclosed. The sample preparation component may be a digital microfluidics module or a surface acoustic wave module which modules are used for combing a sample droplet with a reagent droplet and for performing additional sample preparation step leading to a droplet that contains beads/particles/labels that indicate presence or absence of an analyte of interest in the sample. The beads/particles/labels may be detected by moving the droplet to the detection component of the device, which detection component includes an array of wells.