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    RAPID ALLOGRAFT TREATMENT SYSTEMS AND METHODS
    1.
    发明申请
    RAPID ALLOGRAFT TREATMENT SYSTEMS AND METHODS 有权

    公开(公告)号：US20220160937A1

    公开(公告)日：2022-05-26

    申请号：US17649989

    申请日：2022-02-04

    Applicant: AlloSource

    Inventor： Matthew James Southard ,  Adrian C. Samaniego ,  Kenneth Blood ,  Marina Katelyn Bull ,  Reginald Stilwell ,  Carolyn Barrett Rorick ,  Matthew Peterson ,  Jan Zajdowicz ,  Arthur Joslyn ,  Kathryn Hanzlicek

    IPC: A61L27/36

    Abstract: Provided are systems and methods for treating or processing tissue, and tissue products made using such systems and methods. The methods involve combining tissue with a processing solution in a processing vessel and applying resonant acoustic energy thereto. In some instances, the tissue is processed in the absence of processing solution. The resonant acoustic energy rapidly agitates the tissue with the processing solution by vibration. The general method provided is broadly applicable to a variety of tissue processing methods, the processing solution and features of the resonant acoustic energy being selected based on the type of tissue to be processed and the nature of the processing to be performed. Exemplary methods include methods of bone demineralization, tissue decellularization, tissue cryopreservation, production of stromal vascular fraction, tissue homogenization, tissue cleansing, and tissue decontamination, and assessment of microbial load. By applying resonant acoustic energy to the tissue during processing, the rate or efficiency of processing, or both, may be improved.

    RAPID ALLOGRAFT TREATMENT SYSTEMS AND METHODS
    3.
    发明申请
    RAPID ALLOGRAFT TREATMENT SYSTEMS AND METHODS 审中-公开
    RAPID ALLOGRAFT治疗系统和方法

    公开(公告)号：US20170035937A1

    公开(公告)日：2017-02-09

    申请号：US15231586

    申请日：2016-08-08

    Applicant: AlloSource

    Inventor： Matthew James Southard ,  Adrian C. Samaniego ,  Kenneth Blood ,  Marina Katelyn Bull ,  Reginald Stilwell ,  Carolyn Barrett ,  Matthew Peterson ,  Jan Zajdowicz ,  Arthur Joslyn ,  Kathryn Hanzlicek

    IPC: A61L27/36

    CPC classification number: A61L27/3691 ,  A61L27/3604 ,  A61L27/3608 ,  A61L27/362 ,  A61L27/3683 ,  A61L2430/02

    Abstract: Provided are systems and methods for treating or processing tissue, and tissue products made using such systems and methods. The methods involve combining tissue with a processing solution in a processing vessel and applying resonant acoustic energy thereto. In some instances, the tissue is processed in the absence of processing solution. The resonant acoustic energy rapidly agitates the tissue with the processing solution by vibration. The general method provided is broadly applicable to a variety of tissue processing methods, the processing solution and features of the resonant acoustic energy being selected based on the type of tissue to be processed and the nature of the processing to be performed. Exemplary methods include methods of bone demineralization, tissue decellularization, tissue cryopreservation, production of stromal vascular fraction, tissue homogenization, tissue cleansing, and tissue decontamination, and assessment of microbial load. By applying resonant acoustic energy to the tissue during processing, the rate or efficiency of processing, or both, may be improved.

    Abstract translation: 提供了用于治疗或处理组织的系统和方法，以及使用这种系统和方法制备的组织产品。 所述方法包括将组织与处理容器中的处理溶液组合并向其施加共振声能。 在一些情况下，在没有处理溶液的情况下处理组织。 共振声能通过振动迅速地搅动处理溶液的组织。 提供的一般方法广泛地适用于各种组织处理方法，基于要处理的组织的类型和要执行的处理的性质来选择共振声能的处理方案和特征。 示例性方法包括骨脱矿质，组织脱细胞化，组织冷冻保存，基质血管部分的产生，组织匀浆，组织清洁和组织去污以及微生物负荷评估的方法。 通过在处理期间向组织施加共振声能，可以提高加工速度或效率，或两者。

    SUPERCRITICAL CARBON DIOXIDE TISSUE PROCESSING METHODS
    4.
    发明申请
    SUPERCRITICAL CARBON DIOXIDE TISSUE PROCESSING METHODS 审中-公开
    超临界二氧化碳组织加工方法

    公开(公告)号：US20160008409A1

    公开(公告)日：2016-01-14

    申请号：US14794354

    申请日：2015-07-08

    Applicant: AlloSource

    Inventor： Arthur Joslyn ,  Timothy Walden

    IPC: A61K35/50 ,  C12N5/073

    CPC classification number: A61K35/50 ,  C12N5/0605 ,  C12N2500/02

    Abstract: Embodiments of the present invention may include a method for improving handling characteristics of an amnion tissue. The method may include providing the amnion tissue from a human donor. Furthermore, the method may include exposing the amnion tissue to supercritical carbon dioxide to form an exposed amnion tissue. The exposed amnion tissue may have a higher ultimate tensile strength and elastic modulus than the amnion tissue before the exposure.

    Abstract translation: 本发明的实施方案可以包括用于改善羊膜组织的处理特性的方法。 该方法可以包括从人供体提供羊膜组织。 此外，该方法可以包括将羊膜组织暴露于超临界二氧化碳以形成暴露的羊膜组织。 暴露的羊膜组织可能具有比暴露前的羊膜组织更高的极限拉伸强度和弹性模量。

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