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公开(公告)号：US20250049988A1
公开(公告)日：2025-02-13
申请号：US18798343
申请日：2024-08-08
Applicant: ALLOSOURCE
Inventor： Lauren Castillo , Ergun Kocak , Kenneth Blood , Jeffrey Chiesa , Charles Manuele
IPC: A61L27/36
Abstract: There is disclosed a packaged allograft implant configured for implantation in a human recipient. In an embodiment, the packaged allograft implant includes an acellular dermal matrix sheet having a top surface and a bottom surface in opposition to one another, a perimeter surrounding the top surface and the bottom surface, and a thickness extending between the top surface and the bottom surface. The packaged allograft implant further includes a mesh pattern extending across at least a portion of the top surface and the bottom surface of the acellular dermal matrix sheet, the mesh pattern providing through-holes extending between the top surface and the bottom surface of the acellular dermal matrix sheet, and the mesh pattern having a plurality of mesh lines extending in a first direction and a second direction. The first direction and the second direction are orthogonal to one another so as to allow a given amount of stretch in each of the first direction and the second direction. Other embodiments are also disclosed.
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公开(公告)号：US20220160937A1
公开(公告)日：2022-05-26
申请号：US17649989
申请日：2022-02-04
Applicant: AlloSource
Inventor： Matthew James Southard , Adrian C. Samaniego , Kenneth Blood , Marina Katelyn Bull , Reginald Stilwell , Carolyn Barrett Rorick , Matthew Peterson , Jan Zajdowicz , Arthur Joslyn , Kathryn Hanzlicek
IPC: A61L27/36
Abstract: Provided are systems and methods for treating or processing tissue, and tissue products made using such systems and methods. The methods involve combining tissue with a processing solution in a processing vessel and applying resonant acoustic energy thereto. In some instances, the tissue is processed in the absence of processing solution. The resonant acoustic energy rapidly agitates the tissue with the processing solution by vibration. The general method provided is broadly applicable to a variety of tissue processing methods, the processing solution and features of the resonant acoustic energy being selected based on the type of tissue to be processed and the nature of the processing to be performed. Exemplary methods include methods of bone demineralization, tissue decellularization, tissue cryopreservation, production of stromal vascular fraction, tissue homogenization, tissue cleansing, and tissue decontamination, and assessment of microbial load. By applying resonant acoustic energy to the tissue during processing, the rate or efficiency of processing, or both, may be improved.
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公开(公告)号：US09730796B2
公开(公告)日：2017-08-15
申请号：US14713627
申请日：2015-05-15
Applicant: AlloSource
Inventor： Adrian C. Samaniego , Matthew J. Southard , Kenneth Blood , Richard Dempsey
CPC classification number: A61F2/28 , A61F2002/2835 , A61L27/44 , A61L27/48 , A61L2430/02
Abstract: Embodiments of the present technology include a graft for administration at a treatment site of a patient. The graft may include a human cadaveric bone material bonded together with a polymeric binder. The human cadaveric bone material may include demineralized bone particles. The demineralized bone particles may have an average diameter less than 1.1 mm, less than 750 μm, less than 500 μm, or less than 250 μm. The human cadaveric bone material may include non-demineralized bone, cancellous bone, and/or cortical bone in embodiments. In some embodiments, bone from animals other than humans may be used, and the patient may be an animal other than a human.
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公开(公告)号：US20230329870A1
公开(公告)日：2023-10-19
申请号：US18108061
申请日：2023-02-10
Applicant: ALLOSOURCE
Inventor： Brian White , Christopher Irons , Ruth Bledsoe , Marina Bull , Kenneth Blood
CPC classification number: A61F2/30756 , A61L27/3612 , A61L27/3654 , A61F2002/30461 , A61F2002/3055
Abstract: A pre-sutured allograft construct and method of manufacture for repairing, replacing, reconstructing, or augmenting a hip or shoulder labrum may include a folded tissue portion extending from a first end to a second end and forming top, middle, and bottom folds. A stitched pattern secures the folded tissue portion into a graft roll having an overall length extending from a first adjustable region, through a central region, and through a second adjustable region. A continuous series of whip stitches extends from the first adjustable region, through the central region, and through the second adjustable region. A series of triple circumferential stitches overlays the whip stitches in the first and the second adjustable regions, while a series of circumferential stitches alternates with the whip stitches in the central region. The construct is pre-manufactured as an allograft product, but is adjustable during the surgical procedure within the body. Other embodiments are also disclosed.
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公开(公告)号：US20230145585A1
公开(公告)日：2023-05-11
申请号：US18095910
申请日：2023-01-11
Applicant: ALLOSOURCE
Inventor： Ergun Kocak , Lauren Castillo , Jeffrey Chiesa , Kenneth Blood , Reginald Stilwell
CPC classification number: A61L27/3691 , A61L27/362 , B65B5/045 , A61F2/0095 , A61F2/12 , B65B55/02 , A61L2300/404 , A61L2430/40 , A61L2430/04
Abstract: There is disclosed an acellular dermal matrix (ADM) graft stored as a packaged ADM graft pocket product prepared by a process that includes providing a portion of ADM tissue having a thickness between 1 mm and 2 mm. The process includes scoring the portion of the ADM tissue into a pre-defined shape to form the domed shape ADM graft. The process includes verifying the thickness of the domed shape ADM graft; shaping the domed shape ADM graft to form an ADM graft pocket configured to receive a breast implant. The process includes packaging the ADM graft pocket to form a packaged ADM graft pocket. The process includes irradiating the packaged ADM graft pocket to a sterility assurance level of a desired level to form the packaged ADM graft pocket product. Other embodiments are also disclosed.
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Patent Agency Ranking
公开(公告)号：US20230114297A1
公开(公告)日：2023-04-13
申请号：US17899270
申请日：2022-08-30
Applicant: ALLOSOURCE
Inventor： Ergun Kocak , Lauren Castillo , Jeffrey Chiesa , Kenneth Blood , Reginald Stilwell
Abstract: There is disclosed a tool having a set of features for forming a domed acellular dermal matrix (ADM) graft. An acellular dermal matrix (ADM) graft product includes an ADM graft derived from full-thickness skin, with a pre-formed domed shape having a mesh pattern formed therein. In an embodiment, the set of features include a shaping tool feature and a scoring tool feature. The shaping tool feature has a shaping portion configured to shape a dome shaped ADM graft. The scoring tool feature has a scoring portion configured to impart a desired mesh pattern into the domed shaped ADM graft. Other embodiments are also disclosed.
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公开(公告)号：US20190351102A1
公开(公告)日：2019-11-21
申请号：US16416654
申请日：2019-05-20
Applicant: ALLOSOURCE
Inventor： Aidan Griffin , Tim Bennett , Joslynn Shamis , Luke Shubin , Yurid Gourgel , Lauren Blume , Kenneth Blood , Adrian Samaniego , Bruce Mock , Cathleen Lucine Badillo , Matthew Peterson , Reginald Stilwell
IPC: A61L27/36
Abstract: Systems and methods for the automated demineralization of bone and decellularization of soft tissue include a mixing assembly communicatively coupled with a control and reporting system. The mixing assembly includes a housing that supports a cannister sub-assembly forming a mixing chamber having a reagent inlet, a reagent outlet, and an internal fluid agitator. A motor is operably coupled with the agitator and configured to spin the agitator in first and second directions relative to the cannister, thereby agitating fluid contained within the mixing chamber. At least one pump is configured to progressively inject measured quantities of a plurality of reagents into the mixing chamber. The associated control and reporting system includes a user terminal that displays a graphical user interface enabling a user to initiate an automated demineralization or decellularization procedure in which the mixing assembly demineralizes tissue placed within the mixing chamber. Other embodiments are also disclosed.
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公开(公告)号：US20180280575A1
公开(公告)日：2018-10-04
申请号：US15995320
申请日：2018-06-01
Applicant: AlloSource
Inventor： Ryan Delaney , Matthew James Southard , Adrian C. Samaniego , Kenneth Blood , Marina Katelyn Bull , Reginald Stilwell , Carolyn Barrett Rorick , Matthew Peterson , Jan Zajdowicz , Arthur Joslyn , Kathryn Hanzlicek
Abstract: Provided are systems and methods for treating or processing tissue, and tissue products made using such systems and methods. Also provided are ball mill processing devices and systems useful for processing materials such as tissue. The methods involve combining tissue with or without a processing solution in a processing vessel and applying resonant acoustic energy thereto. The resonant acoustic energy rapidly agitates the tissue with the processing solution by vibration, thereby improving the rate and/or efficiency of processing. The general method provided is broadly applicable to a variety of tissue processing methods, the processing solution and features of the resonant acoustic energy being selected based on the type of tissue to be processed and the nature of the processing to be performed. Exemplary methods include methods of bone demineralization, tissue decellularization, tissue cryopreservation, production of stromal vascular fraction, tissue fragmentation, tissue cleansing, and tissue decontamination, and assessment of microbial load.
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公开(公告)号：US20170367826A1
公开(公告)日：2017-12-28
申请号：US15676305
申请日：2017-08-14
Applicant: AlloSource
Inventor： Adrian C. Samaniego , Matthew J. Southard , Kenneth Blood , Richard Dempsey
CPC classification number: A61F2/28 , A61F2002/2835 , A61L27/44 , A61L27/48 , A61L2430/02
Abstract: Embodiments of the present technology include a graft for administration at a treatment site of a patient. The graft may include a human cadaveric bone material bonded together with a polymeric binder. The human cadaveric bone material may include demineralized bone particles. The demineralized bone particles may have an average diameter less than 1.1 mm, less than 750 μm, less than 500 μm, or less than 250 μm. The human cadaveric bone material may include non-demineralized bone, cancellous bone, and/or cortical bone in embodiments. In some embodiments, bone from animals other than humans may be used, and the patient may be an animal other than a human.
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公开(公告)号：US20160114079A1
公开(公告)日：2016-04-28
申请号：US14923087
申请日：2015-10-26
Applicant: AlloSource
Inventor： Adrian C. Samaniego , Matthew Southard , Kenneth Blood
CPC classification number: A61L27/54 , A61F2002/2835 , A61L27/3604 , A61L27/3834 , A61L2300/414 , A61L2300/64
Abstract: Composite grafts including a biocompatible, synthetic scaffold; and a biological tissue component obtained or derived from a deceased donor tissue, wherein the biological tissue component is embedded in the biocompatible, synthetic scaffold, are provided as systems relating thereto. Methods of manufacture and methods of treatment using such grafts are also provided.
Abstract translation: 复合移植物包括生物相容的合成支架; 以及生物组织组分获得或衍生自死亡供体组织的生物组织成分，其中所述生物组织组分嵌入生物相容的合成支架中，作为与其相关的系统提供。 还提供了使用这种移植物的制造方法和治疗方法。
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