公开(公告)号：US10316320B2

公开(公告)日：2019-06-11

申请号：US14785201

申请日：2014-04-13

Applicant: BAR-ILAN UNIVERSITY

Inventor： Ido Bachelet ,  Almogit Abu-Horowitz ,  Eldad Ben-Ishay ,  Yaniv Amir ,  Joel De Beer ,  Shmulik Ittah

IPC: C12N15/115 ,  A61K47/69 ,  B82Y5/00

Abstract: Systems acting as logic gates and systems exhibiting quorum sensing are provided, wherein said systems comprise at least one effector nucleic acid origami device, at least one regulator nucleic acid origami device, at least one input and at least one output, and the nucleic acid origami devices are non-immunogenic and/or resistant to nucleases.

公开(公告)号：US10420842B2

公开(公告)日：2019-09-24

申请号：US14785185

申请日：2014-04-13

Applicant: BAR-ILAN UNIVERSITY

Inventor： Ido Bachelet ,  Almogit Abu-Horowitz ,  Eldad Ben-Ishay ,  Yaniv Amir ,  Ariel Munitz ,  Anastasia Shapiro ,  Amir Shemer ,  Zeev Zalevsky

IPC: C12N15/115 ,  A61K47/48 ,  C12Q1/68 ,  A61K38/28 ,  A61K47/54 ,  A61K47/69 ,  B82Y5/00

Abstract: Nucleic acid origami devices are provided that are non-immunogenic and/or resistant to nucleases, which may be activated by one or more external cues, such as ligands, glucose concentration or electromagnetic fields; or used for attenuation or prevention of internalization of cell-surface receptors or prolongation of shelf-life of active agents. Further provided are methods for treating diabetes and methods for preparing the devices.