公开(公告)号：US10420842B2

公开(公告)日：2019-09-24

申请号：US14785185

申请日：2014-04-13

Applicant: BAR-ILAN UNIVERSITY

Inventor： Ido Bachelet ,  Almogit Abu-Horowitz ,  Eldad Ben-Ishay ,  Yaniv Amir ,  Ariel Munitz ,  Anastasia Shapiro ,  Amir Shemer ,  Zeev Zalevsky

IPC: C12N15/115 ,  A61K47/48 ,  C12Q1/68 ,  A61K38/28 ,  A61K47/54 ,  A61K47/69 ,  B82Y5/00

Abstract: Nucleic acid origami devices are provided that are non-immunogenic and/or resistant to nucleases, which may be activated by one or more external cues, such as ligands, glucose concentration or electromagnetic fields; or used for attenuation or prevention of internalization of cell-surface receptors or prolongation of shelf-life of active agents. Further provided are methods for treating diabetes and methods for preparing the devices.