公开(公告)号：US20180230104A1

公开(公告)日：2018-08-16

申请号：US15751349

申请日：2016-08-02

Applicant: BASF SE

Inventor： Eric George KLAUBER ,  Timo FRASSETTO ,  Reinhold NIEMES ,  Ralf BAUER ,  Jochen SCHROEDER

IPC: C07D231/22

CPC classification number: C07D231/22 ,  C07D231/04 ,  C07D231/24

Abstract: The present invention relates to a process for preparing crystalline methyl N-[2-[[[1-(4-chlorophenyl)-1H-pyrazol-3-yl]oxy]methyl]phenyl]-N-methoxycarbamate (I), comprising a) reacting a compound of formula II with an alkylating agent in the presence of a base in the presence of a polar solvent selected from alcohols and ketons; b) the addition of water.

公开(公告)号：US20160289157A1

公开(公告)日：2016-10-06

申请号：US15026878

申请日：2014-10-02

Applicant: BASF SE

Inventor： Eric George KLAUBER ,  Michael RACK ,  Thomas ZIERKE ,  Nicole HOLUB ,  David CORTES ,  Gerald SCHMELEBECK ,  Junmin JI

IPC: C07C51/377 ,  C07C67/297 ,  C07F1/00 ,  C07F1/04 ,  C07C37/02 ,  C07C41/16

CPC classification number: C07C51/377 ,  C07C37/02 ,  C07C41/16 ,  C07C67/297 ,  C07F1/005 ,  C07F1/04 ,  C07C39/30 ,  C07C43/225

Abstract: The present invention relates to a process for providing a compound of formula (I): wherein R is hydrogen or R′, wherein R′ is -(C1-C4)alkyl, and Hal is a halogen, the process comprising the step of: reacting a compound of formula (II) wherein Hal is defined as above, with an alkali metal alkoxide of the formula XOR′, wherein X is an alkali metal, and R′ is defined as above.

Abstract translation: 本发明涉及提供式（I）化合物的方法：其中R是氢或R'，其中R'是 - （C 1 -C 4）烷基，而Hal是卤素，该方法包括以下步骤： ：将其中Hal如上定义的式（II）化合物与式XOR'的碱金属醇盐反应，其中X为碱金属，R'如上定义。

公开(公告)号：US20160311747A1

公开(公告)日：2016-10-27

申请号：US15102353

申请日：2014-12-10

Applicant: BASF SE

Inventor： Eric George KLAUBER ,  Michael RACK ,  Thomas ZIERKE ,  Nicole HOLUB ,  David CORTES ,  Gerald SCHMELEBECK ,  Junmin JI

IPC: C07C51/367 ,  C07C51/08

CPC classification number: C07C51/367 ,  C07C45/64 ,  C07C51/08 ,  C07C67/31 ,  C07C253/30 ,  C07C255/54 ,  C07C65/05 ,  C07C69/84 ,  C07C49/825

Abstract: The present invention relates to a process for providing dihalogen substituted salicylic acid derivatives of formula (II):

公开(公告)号：US20160251294A1

公开(公告)日：2016-09-01

申请号：US15026715

申请日：2014-09-25

Applicant: BASF SE

Inventor： Gerald SCHMELEBECK ,  Junmin JI ,  Eric George KLAUBER ,  Michael RACK ,  Thomas ZIERKE ,  Nicole HOLUB ,  David CORTES

IPC: C07C51/09 ,  C07F1/00 ,  C07C67/00 ,  C07C37/02

CPC classification number: C07C51/09 ,  A01N37/40 ,  C07C37/02 ,  C07C51/15 ,  C07C51/367 ,  C07C67/00 ,  C07F1/005 ,  C07C39/30 ,  C07C65/05 ,  C07C65/21

Abstract: The present invention relates to a process for providing a compound of formula (I): wherein Hal is a halogen, the process comprising the step of: reacting a compound of formula (II) wherein Hal is defined as above, with an alkali metal sulfite of the formula X2SO3 and an alkali metal hydroxide of the formula YOH, wherein X and Y are independently selected from an alkali metal.

Abstract translation: 本发明涉及提供式（I）化合物的方法：其中Hal为卤素，该方法包括以下步骤：使其中Hal如上定义的式（II）化合物与碱金属亚硫酸盐反应 的式X 2 SO 3和式YOH的碱金属氢氧化物，其中X和Y独立地选自碱金属。

公开(公告)号：US20210087207A1

公开(公告)日：2021-03-25

申请号：US16610186

申请日：2018-05-02

Applicant: BASF SE

Inventor： Harish SHINDE ,  Christopher KORADIN ,  Joachim DICKHAUT ,  Roland GOETZ ,  Eric George KLAUBER ,  Sukunath NARAYANAN ,  Dhanyakumar RAUT

IPC: C07D513/04

Abstract: The present invention relates to a process for preparing optically active compounds of formula X and intermediates thereof, wherein the variables of compound of formula X are as defined in the claims and the description.

公开(公告)号：US20200055872A1

公开(公告)日：2020-02-20

申请号：US16608290

申请日：2018-04-25

Applicant: BASF SE

Inventor： Harish SHINDE ,  Christopher KORADIN ,  Joachim DICKHAUT ,  Roland GOETZ ,  Michael RACK ,  Eric George KLAUBER ,  Sukunath NARAYANAN ,  Dhanyakumar RAUT

IPC: C07D513/04 ,  C07D417/04 ,  C07D277/32

Abstract: The present invention relates to a process for preparing optically active compounds of formula X and intermediates thereof, wherein the variables of compound of formula X are as defined in the claims or the description.

公开(公告)号：US20170008824A1

公开(公告)日：2017-01-12

申请号：US15119654

申请日：2015-02-19

Applicant: BASF SE

Inventor： Eric George KLAUBER ,  Michael RACK ,  Thomas ZIERKE ,  Nicole HOLUB ,  Gerald SCHMELEBECK ,  Junmin JI ,  David CORTES

IPC: C07C41/16 ,  C07C51/16 ,  C07C37/62

CPC classification number: C07C41/16 ,  C07C37/02 ,  C07C37/62 ,  C07C51/16 ,  C07C51/285 ,  C07C65/21 ,  C07C43/225 ,  C07C39/30 ,  C07C39/28

Abstract: The present invention relates to a process for providing a compound of formula (IV): wherein R1 and R2 are each independently C1-C4 alkyl, and Hal is independently Cl or Br, the process comprising the steps of: (i) reacting a compound of formula (II) wherein R1 and Hal is defined as above, to obtain a compound of formula (III) wherein R1 and Hal is defined as above, and (ii) reacting the compound of formula (III) to obtain the compound of formula (IV).

Abstract translation: 其中R1和Hal如上定义，和（ii）使式（III）化合物反应得到式（IV）化合物。

公开(公告)号：US20190308954A1

公开(公告)日：2019-10-10

申请号：US16347414

申请日：2017-10-27

Applicant: BASF SE

Inventor： Eric George KLAUBER ,  Birgit GOCKEL ,  Sebastian SOERGEL ,  Roland GOETZ ,  Henricus Maria Martinus BASTIAANS, I ,  Jochen DIETZ ,  Joachim GEBHARDT

IPC: C07D403/12

Abstract: The present invention relates to a process for the purification of pyrazolpyridazines of formula I wherein the variables are as defined in the specification, by adding HCl to a solution of the pyrazolpyridazine in an inert solvent under non-aqueous conditions, effecting crystallization of the HCl-salt, isolating the resulting precipitate.

公开(公告)号：US20190055200A1

公开(公告)日：2019-02-21

申请号：US16074537

申请日：2017-01-25

Applicant: BASF SE

Inventor： Eric George KLAUBER ,  Michael RACK ,  Sebastian SOERGEL ,  Birgit GOCKEL ,  Roland GOETZ

IPC: C07D231/14 ,  B01J21/18 ,  B01J23/42 ,  C07D401/12 ,  C07D403/12

Abstract: The present invention relates to a catalytic process for preparing pyrazoles comprising the step of cyclizing hydrazone substituted α,β-unsaturated carbonyl compounds by reacting them with hydrogen in a reaction mixture comprising as components (a) a hydrogenation catalyst, (b) an acid selected from Brønsted acids, ammonium salts of Brønsted acids, and Lewis acids, (c) a protic solvent, and optionally (d) an aprotic solvent.

公开(公告)号：US20180141917A1

公开(公告)日：2018-05-24

申请号：US15572303

申请日：2016-05-10

Applicant: BASF SE

Inventor： Eric George KLAUBER ,  Michael RACK ,  Roland GOETZ ,  Sebastian SÖRGEL

IPC: C07D237/20 ,  C07D237/12 ,  C07D403/12 ,  C07B43/04 ,  C07B39/00 ,  C07B31/00

Abstract: Provided herein is a process for preparing a pyridazine amine compound of formula V, and a process for preparing dichloropyridazine amine compounds of formula IVa, IVb, and mixtures thereof. Further, provided herein are novel dichloropyridazine amine compounds of formula IVa, IVb, and mixtures thereof, wherein the amino group is an ethylamino group.