公开(公告)号：US3748357A

公开(公告)日：1973-07-24

申请号：US3748357D

申请日：1970-06-08

Applicant: BAYER AG

Inventor： OERTEL H ,  EHOLZER U ,  ROSENDAHL F

IPC: C07D295/28 ,  C08F2/38 ,  C10L1/14 ,  C10L1/22 ,  C10L1/24 ,  C07C133/02

CPC classification number: C07D295/32 ,  C08F2/40 ,  C10L1/14 ,  C10L1/226 ,  C10L1/231 ,  C10L1/232 ,  C10L1/2412 ,  C10L1/2456

Abstract: A SEMICARBAZIDE OF THE FORMULA:

1-((R'')2-N-NH-CO-NH-(CH2)N-CH2-),3-R2,5-R1,HO-BENZENE

WHEREIN RR1 IS SELECTED FROM THE GROUP OF TERTIARY BUTYL, TERTIARY AMYL, TERTIARY OCTYL AND TERTIARY DODECYL; R2 IS ALKYL WITH 1 TO 12 CARBON ATOMS, PREFERABLY UNSUBSTITUTED ALKYL WITH 1 TO 4 CARBON ATOMS SUCH AS METHYL OR TERTIARY BUTYL; R'' IS ALKYL WITH 1 TO 12 CARBON ATOMS WHICH CAN BE SUBSTITUTED WITH A HYDROXYL, HALOGEN OR MERCAPTO GROUP, PREFERABLY ALKYL WITH 1 TO 4 CARBON ATOMS SUCH AS METHYL, HYDROXY ETHYL OR HYDROXY PROPYL; N IS AN INTEGER FROM 0 TO 12, PREFERABLY 0 TO 2; AND WITH THE PROVISO THAT THE -OH GROUP IS ORTHO OR R1. SUCH COMPOUNDS ARE USEFUL TO STABILIZE ISOCYANATES AGAINST DISCOLORATION DURING STORAGE.

公开(公告)号：US3758553A

公开(公告)日：1973-09-11

申请号：US3758553D

申请日：1971-01-28

Applicant: BAYER AG

Inventor： WINKELMANN H ,  ROSENDAHL F ,  OERTEL H ,  RINKE H

IPC: C07C20060101 ,  C07C101/04

CPC classification number: C07C229/08

Abstract: This invention relates to a process for the production of Beta -formylaminopropionic acid esters by reacting formamide with acrylic acid esters in the presence of a basic catalyst at normal pressure and at a relatively low temperature. The Beta formylaminopropionic acid esters produced in accordance with the invention are valuable intermediate products for the production of derivatives of Beta -alanine and for the production of Beta -alanine itself, both of which are of pharmaceutical interest or may be used as starting materials in the making of polyamides or polyurethanes.

Abstract translation: 本发明涉及一种通过甲酰胺与丙烯酸酯在碱性催化剂存在下在常压和较低温度下反应生产β-甲酰氨基丙酸酯的方法。 根据本发明制备的β-甲酰氨基丙酸酯是用于生产β-丙氨酸衍生物和β-丙氨酸本身的生产的有价值的中间产物，它们都是药物感兴趣的或可用作起始原料 聚酰胺或聚氨酯的制造。