公开(公告)号：US3814582A

公开(公告)日：1974-06-04

申请号：US23135172

申请日：1972-03-02

Applicant: BECKMAN INSTRUMENTS INC

Inventor： CHASE C ,  PEARSON W ,  ROHRBAUGH D ,  PETERSEN E

IPC: G01N35/02 ,  G01N35/10 ,  G01N1/14 ,  G01N1/18

CPC classification number: G01N35/025 ,  G01N2035/1088 ,  Y10T436/11 ,  Y10T436/114998

Abstract: A MODULAR CHEMICAL ANALYSER SYSTEM PROVIDES FOR THE ANALYSIS OF A WIDE RANGE OF CHEMICAL PRODUCTS IN DIVERSE SERIALIZED REPETITIVE AUTOMATED PROCESSES. TYPICALLY, A SOLID TABLET SAMPLE IS PLACED IN A SAMPLE REACTOR MODULE AND THIS MODULE IS PAIRED WITH AN ANALYSIS TUBE MODULE, BOTH POSITIONED IN SPECIFIC APERTURES OF A CHEMICAL ANALYSIS ROTARY MODULE. A CHEMICAL ANALYSIS SAMPLE DISSOLVER MODULE TYPICALLY COOPERATIVELY PROVIDES A SCHEDULED SOLVENT VOLUME, DISRUPTS, STIRS AND DISSOLVES THE SAMPLE IN THE SOLVENT, AND MAKES A FILTERED SOLUTION AVAILABLE IN THE REACTOR MODULE. EACH REACTTOR MODULE ACCOMMODATES AN INDIVIDUAL SAMPLE SOLUTION IN THE SEQUENTIAL PROCESSING ON THE ROTARY MODULE. A MULTIPLICITY OF COOPERATIVE LIQUID VOLUME PROBE MEANS ARE CONCENTRICALLY DISPOSED ON A CENTRAL RECIPROCATING ELEVATOR MEANS. THEY PROVIDE, IN

CONJUNCTION WITH A MULTIPLICITY OF CHEMICAL SOLUTION PUMP MEANS, PROGRAMMED INDIVIDUAL VOLUMES OF INDIVIDUAL CHEMICAL SOLUTIONS SUITABLE FOR CHEMICALLY PROCESSING THE SAMPLE SOLUTION IN A SERIALIZED SPECIFIC PAIR OF REACTOR MODULE AND TUBE MODULE. THE SYSTEM FINALLY YIELDS AN ALIQUOT ANALYSIS SOLUTION SAMPLE SUITABLE FOR A DIRECT QUANTITATIVE CHEMICAL ANALYSIS MEASUREMENT, AS BY A SPECTROPHOTOMETER OR THE LIKE.

公开(公告)号：US3724765A

公开(公告)日：1973-04-03

申请号：US3724765D

申请日：1971-09-03

Applicant: BECKMAN INSTRUMENTS INC

Inventor： ROHRBAUGH D ,  PETERSEN E

IPC: A47J43/07 ,  B02C18/06 ,  B02C18/10 ,  B02C13/18

CPC classification number: A47J43/0705 ,  B02C18/062

Abstract: A disruptor device particularly suited for rapidly grinding up pharmaceutical tablets in a liquid and agitating the mixture to dissolve the active ingredients of the tablets in the liquid for subsequent chemical analysis. The device comprises a rotatable shaft extending through a hollow member which is formed at its lower end with a series of circularly arranged spaced teeth. The shaft carries at its lower end a rotor provided with a plurality of teeth which are surrounded by the teeth on the hollow member. Rotation of the rotor draws the tablet and liquid upward into the rotor and propels the mixture radially outward through the teeth in the hollow member whereby the tablet will be severed and broken into pieces by the shearing action between the two sets of teeth. Some of the teeth on the outer hollow member are shorter than the other teeth thereon so as to provide entrance openings for large particles to enter the head of the device. An inverted conical shaped deflector is provided on the bottom of the rotor to eliminate stagnant eddy currents within the rotor.

Abstract translation: 一种破碎装置，特别适用于快速研磨液体中的药片并搅拌该混合物以将片剂的活性成分溶解在液体中用于随后的化学分析。 该装置包括延伸穿过中空构件的可旋转轴，其在其下端形成有一系列圆形排列的间隔开的齿。 该轴在其下端承载设置有多个齿的转子，该多个齿由中空构件上的齿包围。 转子的旋转将片剂和液体向上拉动到转子中并通过中空构件中的齿推动混合物径向向外，由此片剂将被两组齿之间的剪切作用切断并分裂成碎片。 外部中空构件上的一些齿比其它齿更短，以便为大颗粒提供进入装置头部的入口。 在转子的底部设置倒锥形偏转器，以消除转子内的停滞的涡流。