公开(公告)号：US3788815A

公开(公告)日：1974-01-29

申请号：US3788815D

申请日：1972-03-02

Applicant: BECKMAN INSTRUMENTS INC

Inventor： ROHRBAUGH D

IPC: B01L3/14 ,  G01N1/10 ,  G01N1/14

CPC classification number: B01L3/5082

Abstract: AN ELONGATED SAMPLE SOLUTION CUP HAS A CROSS SECTION ADAPTED TO INDUCING TURBULENCE IN A SOLVENT STIRRED IN THE CUP, AND HAS AN OFFSET RECESSED BOTTOM CAVITY PROVIDING A LOCALIZED DISSOLVER VOLUME FOR SOLID SAMPLES INTRODUCED INTO THE CUP. A REMOVABLE FILTER TUBE PROVIDES A FILTERED SAMPLE SOLUTION FOR FURTHER WET ANALYSIS. THE REACTOR MODULE COMPRISING THE SOLUTION CUP AND THE REMOVABLE FILTER TUBE IS MADE OF A THIN WALL THERMOPLASTIC MATERIAL, SUITABLE FOR USING ONE OR MORE TIMES.

公开(公告)号：US3814582A

公开(公告)日：1974-06-04

申请号：US23135172

申请日：1972-03-02

Applicant: BECKMAN INSTRUMENTS INC

Inventor： CHASE C ,  PEARSON W ,  ROHRBAUGH D ,  PETERSEN E

IPC: G01N35/02 ,  G01N35/10 ,  G01N1/14 ,  G01N1/18

CPC classification number: G01N35/025 ,  G01N2035/1088 ,  Y10T436/11 ,  Y10T436/114998

Abstract: A MODULAR CHEMICAL ANALYSER SYSTEM PROVIDES FOR THE ANALYSIS OF A WIDE RANGE OF CHEMICAL PRODUCTS IN DIVERSE SERIALIZED REPETITIVE AUTOMATED PROCESSES. TYPICALLY, A SOLID TABLET SAMPLE IS PLACED IN A SAMPLE REACTOR MODULE AND THIS MODULE IS PAIRED WITH AN ANALYSIS TUBE MODULE, BOTH POSITIONED IN SPECIFIC APERTURES OF A CHEMICAL ANALYSIS ROTARY MODULE. A CHEMICAL ANALYSIS SAMPLE DISSOLVER MODULE TYPICALLY COOPERATIVELY PROVIDES A SCHEDULED SOLVENT VOLUME, DISRUPTS, STIRS AND DISSOLVES THE SAMPLE IN THE SOLVENT, AND MAKES A FILTERED SOLUTION AVAILABLE IN THE REACTOR MODULE. EACH REACTTOR MODULE ACCOMMODATES AN INDIVIDUAL SAMPLE SOLUTION IN THE SEQUENTIAL PROCESSING ON THE ROTARY MODULE. A MULTIPLICITY OF COOPERATIVE LIQUID VOLUME PROBE MEANS ARE CONCENTRICALLY DISPOSED ON A CENTRAL RECIPROCATING ELEVATOR MEANS. THEY PROVIDE, IN

CONJUNCTION WITH A MULTIPLICITY OF CHEMICAL SOLUTION PUMP MEANS, PROGRAMMED INDIVIDUAL VOLUMES OF INDIVIDUAL CHEMICAL SOLUTIONS SUITABLE FOR CHEMICALLY PROCESSING THE SAMPLE SOLUTION IN A SERIALIZED SPECIFIC PAIR OF REACTOR MODULE AND TUBE MODULE. THE SYSTEM FINALLY YIELDS AN ALIQUOT ANALYSIS SOLUTION SAMPLE SUITABLE FOR A DIRECT QUANTITATIVE CHEMICAL ANALYSIS MEASUREMENT, AS BY A SPECTROPHOTOMETER OR THE LIKE.

公开(公告)号：US3785773A

公开(公告)日：1974-01-15

申请号：US3785773D

申请日：1972-03-02

Applicant: BECKMAN INSTRUMENTS INC

Inventor： ROHRBAUGH D

IPC: B01L3/00 ,  B01L9/06 ,  G01N1/10 ,  G01N1/14 ,  G01N1/18

CPC classification number: B01L3/5085 ,  B01L9/06

Abstract: An integral, thin wall thermoplastic chemical analysis tube module has a plurality of test tubular receptacles disposed normally to an elongated rectangular planar area and has a surrounding first wall frame segment of uniform height secured to and supportively disposed around a perimeter major segment of the planar area. A first uniform stiffener lip is integrally secured to and disposed around the first frame segment opposite the planar area. An opposed pair of second wall frame segments having a second uniform height is secured to and supportively oppositely disposed around a pair of opposed perimeter minor segments of the planar area. The second wall height is precisely greater than the first wall height. A pair of second uniform stiffener lips is secured to and disposed around the second frame segment perimeter, also opposed to the planar area. The temporary compressive displacement of the second pair of stiffener lips inside the perimeter of the first pair of stiffener lips provides an expansive precise jaw clamp on release of the clamp, which can secure the tube module combination in a configured cut out aperture in a supporting plate.

Abstract translation: 整体的薄壁热塑性化学分析管模块具有多个通常连接到细长矩形平面区域的测试管状容器，并且具有均匀高度的周围的第一壁框架段，其固定并围绕平面区域的周边主要部分 。 第一均匀的加强件唇部一体地固定到第一框架部分周围并且布置在与平面区域相对的第一框架部分周围。 具有第二均匀高度的相对的一对第二壁框架段固定到平面区域的一对相对的周边小部分周围并且相对地布置。 第二壁高度精确地大于第一壁高度。 一对第二均匀的加强筋唇缘固定到第二框架段周边并且围绕第二框架段周边设置，也与平面区域相对。 第二对加强筋唇缘在第一对加强筋唇缘的周边内的临时压缩位移在夹具释放时提供了一个膨胀的精确夹钳，这可以将管组件组合固定在支撑板上的一个配置的切口孔中 。

公开(公告)号：US3724765A

公开(公告)日：1973-04-03

申请号：US3724765D

申请日：1971-09-03

Applicant: BECKMAN INSTRUMENTS INC

Inventor： ROHRBAUGH D ,  PETERSEN E

IPC: A47J43/07 ,  B02C18/06 ,  B02C18/10 ,  B02C13/18

CPC classification number: A47J43/0705 ,  B02C18/062

Abstract: A disruptor device particularly suited for rapidly grinding up pharmaceutical tablets in a liquid and agitating the mixture to dissolve the active ingredients of the tablets in the liquid for subsequent chemical analysis. The device comprises a rotatable shaft extending through a hollow member which is formed at its lower end with a series of circularly arranged spaced teeth. The shaft carries at its lower end a rotor provided with a plurality of teeth which are surrounded by the teeth on the hollow member. Rotation of the rotor draws the tablet and liquid upward into the rotor and propels the mixture radially outward through the teeth in the hollow member whereby the tablet will be severed and broken into pieces by the shearing action between the two sets of teeth. Some of the teeth on the outer hollow member are shorter than the other teeth thereon so as to provide entrance openings for large particles to enter the head of the device. An inverted conical shaped deflector is provided on the bottom of the rotor to eliminate stagnant eddy currents within the rotor.

Abstract translation: 一种破碎装置，特别适用于快速研磨液体中的药片并搅拌该混合物以将片剂的活性成分溶解在液体中用于随后的化学分析。 该装置包括延伸穿过中空构件的可旋转轴，其在其下端形成有一系列圆形排列的间隔开的齿。 该轴在其下端承载设置有多个齿的转子，该多个齿由中空构件上的齿包围。 转子的旋转将片剂和液体向上拉动到转子中并通过中空构件中的齿推动混合物径向向外，由此片剂将被两组齿之间的剪切作用切断并分裂成碎片。 外部中空构件上的一些齿比其它齿更短，以便为大颗粒提供进入装置头部的入口。 在转子的底部设置倒锥形偏转器，以消除转子内的停滞的涡流。

公开(公告)号：US3788816A

公开(公告)日：1974-01-29

申请号：US3788816D

申请日：1972-03-02

Applicant: BECKMAN INSTRUMENTS INC

Inventor： ROHRBAUGH D ,  PEARSON W

IPC: G01N35/02 ,  G01N35/04 ,  G01N35/10 ,  G01N1/10 ,  G01N1/18

CPC classification number: G01N35/04 ,  G01N35/025 ,  G01N2035/0446 ,  G01N2035/1088

Abstract: A CHEMICAL SAMPLE REACTOR MODULE, CONTAINING A SOLUTION OF A CHEMICAL SAMPLE PREPARED FOR ANALYSIS, IS COOPERATIVELY PAIRED WITH A CHEMICAL ANALYSIS TUBE MODULE IN PRECISE RADIAL ALIGNMENT IN A ROTARY INDEX TABLE. MULTIPLE PAIRED MODULES ARE RADIALLY COALIGNED IN THE TABLE DURING THE CONSECUTIVE ANALYSIS OF A SERIES OF CHEMICAL SAMPLES. PLURAL SAMPLE PROBES, HAVING INDIVIDUALLY ADJUSTED VERTICAL AND HORIZONTAL DISPLACEMENT TRAVERSES, ARE EACH INDIVIDUALLY POSITIONED AS REQUIRED ON A RECIPROCATING, VERTICALLY DISPLACEABLE CENTRAL PEDESTAL, PROVIDING REPETITIVE PROGRAMMED TRANSFER AND ADDITION OF METERED REAGENT VOLUMES TO ALIQUOT SOLUTION SAMPLES. THE ROTARY INDEX TABLE SEQUENTIALLY PROVIDES A PRECISE TIMED PERIOD FOR EACH ALIQUOT SAMPLE SOLUTION TO UNIFORMLY REACT WITH PRECISE REAGENT VOLUMES IN A CHEMICAL ANALYSIS PROCEDURE. UTILIZING AN AUTOMATED SAMPLE PROBE, A FINAL ALIQUOT ANALYSIS PROCEDURE SAMPLE IS MEASURED FOR A COMPONENT CONCENTRATION IN A COOPERATIVE ANALYTICAL INSTRUMENT.