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公开(公告)号：US20190046456A1
公开(公告)日：2019-02-14
申请号：US16076849
申请日：2017-02-08
Applicant: BIOGEN MA INC.
Inventor： Shyam B. Karki , Peter Zawaneh , Cheuk-Yui Leung , Kalyan Vasudevan , Yiqing Lin , Jin Xu , Andrea Trementozzi , Ivan Nestorov
IPC: A61K9/50 , A61K31/225 , A61K9/48
Abstract: The present invention provides novel pharmaceutical compositions of dimethyl fumarate. The pharmaceutical compositions of the present invention comprises a first pharmaceutical bead composition and a second pharmaceutical bead composition, wherein the first pharmaceutical bead composition is an enterically coated immediate-release composition and the second pharmaceutical bead composition is an enterically coated controlled-release composition, wherein the first pharmaceutical bead composition and the second pharmaceutical bead composition both comprise dimethyl fumarate Methods of using the pharmaceutical compositions of the present invention for treating multiple sclerosis are also included.
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公开(公告)号：US11291642B2
公开(公告)日：2022-04-05
申请号：US15737011
申请日：2016-06-15
Applicant: BIOGEN MA INC.
Inventor： Pierre Boulas , Erwin Irdam , Shyam B. Karki , William F. Kiesman , Cheuk-Yui Leung , Yiqing Lin , Andrea Trementozzi , Peter Zawaneh
IPC: A61K31/225 , A61K9/00 , A61K9/50 , A61K9/14 , A61K9/48 , A61K9/16 , A61K47/10 , A61K47/14 , A61K47/42 , A61P25/00
Abstract: The present invention provides dimethyl fumarate (DMF) particles and methods of preparing the DMF particles. Also provided is DMF coated particles comprising DMF particles coated with an enteric coating. The invention also provides various dosage forms and methods of treating a disease or disorder (e.g., multiple sclerosis).
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公开(公告)号：US11197842B2
公开(公告)日：2021-12-14
申请号：US15527531
申请日：2015-11-19
Applicant: BIOGEN MA INC.
Inventor： Shyam B. Karki , Peter Zawaneh , Cheuk-Yui Leung , Kalyan Vasudevan , Yiqing Lin , Jin Xu , Andrea Trementozzi
Abstract: The present invention provides novel pharmaceutical compositions of dimethyl fumarate. The pharmaceutical compositions of the present invention are in the form of a bead and comprise (i) an inert core; (ii) a first layer surrounding the inert core, wherein the first layer comprises dimethyl fumarate; and (iii) an enteric coating surrounding the first layer. Also provided are pharmaceutical compositions in the form of a bead comprising a core and an enteric coating surrounding the core, wherein the core comprises dimethyl fumarate. Methods of using the pharmaceutical compositions of the present invention for treating multiple sclerosis are also included.
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Patent Agency Ranking
公开(公告)号：US20210369629A1
公开(公告)日：2021-12-02
申请号：US17319694
申请日：2021-05-13
Applicant: BIOGEN MA INC.
Inventor： Shyam B. Karki , Peter Zawaneh , Cheuk-Yui Leung , Kalyan Vasudevan , Yiqing Lin , Jin Xu , Andrea Trementozzi , Ivan Nestorov
IPC: A61K9/50 , A61K31/225 , A61K9/48
Abstract: The present invention provides novel pharmaceutical compositions of dimethyl fumarate. The pharmaceutical compositions of the present invention comprises a first pharmaceutical bead composition and a second pharmaceutical bead composition, wherein the first pharmaceutical bead composition is an enterically coated immediate-release composition and the second pharmaceutical bead composition is an enterically coated controlled-release composition, wherein the first pharmaceutical bead composition and the second pharmaceutical bead composition both comprise dimethyl fumarate Methods of using the pharmaceutical compositions of the present invention for treating multiple sclerosis are also included.
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公开(公告)号：US20220362195A1
公开(公告)日：2022-11-17
申请号：US17677204
申请日：2022-02-22
Applicant: BIOGEN MA INC.
Inventor： Pierre Boulas , Erwin Irdam , Shyam B. Karki , William F. Kiesman , Cheuk-Yui Leung , Yiqing Lin , Andrea Trementozzi , Peter Zawaneh
IPC: A61K31/225 , A61K9/00 , A61K9/50 , A61K9/14 , A61K9/48 , A61K9/16 , A61K47/10 , A61K47/14 , A61K47/42
Abstract: The present invention provides dimethyl fumarate (DMF) particles and methods of preparing the DMF particles. Also provided is DMF coated particles comprising DMF particles coated with an enteric coating. The invention also provides various dosage forms and methods of treating a disease or disorder (e.g., multiple sclerosis).
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公开(公告)号：US11033509B2
公开(公告)日：2021-06-15
申请号：US16076849
申请日：2017-02-08
Applicant: BIOGEN MA INC.
Inventor： Shyam B. Karki , Peter Zawaneh , Cheuk-Yui Leung , Kalyan Vasudevan , Yiqing Lin , Jin Xu , Andrea Trementozzi , Ivan Nestorov
Abstract: The present invention provides novel pharmaceutical compositions of dimethyl fumarate. The pharmaceutical compositions of the present invention comprises a first pharmaceutical bead composition and a second pharmaceutical bead composition, wherein the first pharmaceutical bead composition is an enterically coated immediate-release composition and the second pharmaceutical bead composition is an enterically coated controlled-release composition, wherein the first pharmaceutical bead composition and the second pharmaceutical bead composition both comprise dimethyl fumarate Methods of using the pharmaceutical compositions of the present invention for treating multiple sclerosis are also included.
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公开(公告)号：US20190070143A1
公开(公告)日：2019-03-07
申请号：US15737011
申请日：2016-06-15
Applicant: BIOGEN MA INC.
Inventor： Pierre Boulas , Erwin Irdam , Shyam B. Karki , William F. Kiesman , Cheuk-Yui Leung , Yiqing Lin , Andrea Trementozzi , Peter Zawaneh
Abstract: The present invention provides dimethyl fumarate (DMF) particles and methods of preparing the DMF particles. Also provided is DMF coated particles comprising DMF particles coated with an enteric coating. The invention also provides various dosage forms and methods of treating a disease or disorder (e.g., multiple sclerosis).
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公开(公告)号：US20180153845A1
公开(公告)日：2018-06-07
申请号：US15527531
申请日：2015-11-19
Applicant: BIOGEN MA INC.
Inventor： Shyam B. Karki , Peter Zawaneh , Cheuk-Yui Leung , Kalyan Vasudevan , Yiqing Lin , Jin Xu , Andrea Trementozzi
CPC classification number: A61K31/225 , A61K9/1676 , A61K9/209 , A61K9/2826 , A61K9/2846 , A61K9/2853 , A61K9/2866 , A61K9/2873 , A61K9/288 , A61K9/2886 , A61K9/5078 , A61P25/00 , A61P37/00
Abstract: The present invention provides novel pharmaceutical compositions of dimethyl fumarate. The pharmaceutical compositions of the present invention are in the form of a bead and comprise (i) an inert core; (ii) a first layer surrounding the inert core, wherein the first layer comprises dimethyl fumarate; and (iii) an enteric coating surrounding the first layer. Also provided are pharmaceutical compositions in the form of a bead comprising a core and an enteric coating surrounding the core, wherein the core comprises dimethyl fumarate. Methods of using the pharmaceutical compositions of the present invention for treating multiple sclerosis are also included.
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