公开(公告)号：US20200062705A1

公开(公告)日：2020-02-27

申请号：US16610817

申请日：2018-05-18

Applicant: Biogen MA Inc.

Inventor： Nishanth Gopinathan ,  Erwin Irdam ,  William Kiesman ,  Daw-long A. Kwok ,  Yiqing Lin ,  Frederick Osei-Yeboah ,  Matthew Peterson ,  Kenny Tran ,  Kalyan Vasudevan

IPC: C07D207/16

Abstract: The present invention is directed to novel crystalline forms of 5-(4-{[(2-fluorophenyl)methyl]oxy}phenyl)-prolinamide hydrochloride, to the use of said crystalline forms in treating diseases and conditions mediated by modulation of voltage-gated sodium channels, to compositions containing said crystalline forms and processes for their preparation.

公开(公告)号：US20240400506A1

公开(公告)日：2024-12-05

申请号：US18692541

申请日：2022-09-16

Applicant: BIOGEN MA INC.

Inventor： Liang Chen ,  Erwin Irdam ,  Daw-long Albert Kwok ,  Nocole Madden ,  John Mascho

IPC: C07D207/404 ,  A61K9/20 ,  A61K31/4015

Abstract: Many active pharmaceutical ingredients (API) are available in tablet form. Particles of the API should have a favorable compaction profile in order to be compressed into tablets, especially when the API is present in a large weight percentage in the tablet. Disclosed herein are particles of diroximel fumarate having improved characteristic for tablet formation, and methods of producing the same.

公开(公告)号：US20220098150A1

公开(公告)日：2022-03-31

申请号：US17322382

申请日：2021-05-17

Applicant: Biogen MA Inc.

Inventor： Nishanth Gopinathan ,  Erwin Irdam ,  William Kiesman ,  Daw-long A. Kwok ,  Yiqing Lin ,  Frederick Osei-Yeboah ,  Matthew Peterson ,  Kenny Tran ,  Kalyan Vasudevan

IPC: C07D207/16

Abstract: The present invention is directed to novel crystalline forms of 5-(4-{[2-fluorophenyl)methyl]oxy}phenyl-prolinamide hydrochloride, to the use of said crystalline forms in treating diseases and conditions mediated by modulation of voltage-gated sodium channels, to compositions containing said crystalline forms and processes for their preparation.

公开(公告)号：US20220362195A1

公开(公告)日：2022-11-17

申请号：US17677204

申请日：2022-02-22

Applicant: BIOGEN MA INC.

Inventor： Pierre Boulas ,  Erwin Irdam ,  Shyam B. Karki ,  William F. Kiesman ,  Cheuk-Yui Leung ,  Yiqing Lin ,  Andrea Trementozzi ,  Peter Zawaneh

IPC: A61K31/225 ,  A61K9/00 ,  A61K9/50 ,  A61K9/14 ,  A61K9/48 ,  A61K9/16 ,  A61K47/10 ,  A61K47/14 ,  A61K47/42

Abstract: The present invention provides dimethyl fumarate (DMF) particles and methods of preparing the DMF particles. Also provided is DMF coated particles comprising DMF particles coated with an enteric coating. The invention also provides various dosage forms and methods of treating a disease or disorder (e.g., multiple sclerosis).

公开(公告)号：US20190070143A1

公开(公告)日：2019-03-07

申请号：US15737011

申请日：2016-06-15

Applicant: BIOGEN MA INC.

Inventor： Pierre Boulas ,  Erwin Irdam ,  Shyam B. Karki ,  William F. Kiesman ,  Cheuk-Yui Leung ,  Yiqing Lin ,  Andrea Trementozzi ,  Peter Zawaneh

IPC: A61K31/225 ,  A61K9/16 ,  A61K9/00 ,  A61K47/14 ,  A61K47/10 ,  A61K47/42

Abstract: The present invention provides dimethyl fumarate (DMF) particles and methods of preparing the DMF particles. Also provided is DMF coated particles comprising DMF particles coated with an enteric coating. The invention also provides various dosage forms and methods of treating a disease or disorder (e.g., multiple sclerosis).

公开(公告)号：US20240308958A1

公开(公告)日：2024-09-19

申请号：US18571090

申请日：2022-06-14

Applicant: BIOGEN MA INC.

Inventor： Daw-long Albert KWOK ,  Chao Fei ,  Erwin Irdam ,  Donald Walker ,  Markus Grohmann ,  Jens Mohr ,  Janina Bucher

IPC: C07D207/404

CPC classification number: C07D207/404

Abstract: Disclosed is a method of preparing diroximel fumarate represented by the following structural formula (I) The method comprises reacting ethy lene carbonate with succinimide to form a hydroxyethyl succinimide intermediate; and reacting the intermediate with monomethyl fumarate to form the product compound.

公开(公告)号：US11291642B2

公开(公告)日：2022-04-05

申请号：US15737011

申请日：2016-06-15

Applicant: BIOGEN MA INC.

Inventor： Pierre Boulas ,  Erwin Irdam ,  Shyam B. Karki ,  William F. Kiesman ,  Cheuk-Yui Leung ,  Yiqing Lin ,  Andrea Trementozzi ,  Peter Zawaneh

IPC: A61K31/225 ,  A61K9/00 ,  A61K9/50 ,  A61K9/14 ,  A61K9/48 ,  A61K9/16 ,  A61K47/10 ,  A61K47/14 ,  A61K47/42 ,  A61P25/00

Abstract: The present invention provides dimethyl fumarate (DMF) particles and methods of preparing the DMF particles. Also provided is DMF coated particles comprising DMF particles coated with an enteric coating. The invention also provides various dosage forms and methods of treating a disease or disorder (e.g., multiple sclerosis).