公开(公告)号：US20230406878A1

公开(公告)日：2023-12-21

申请号：US18036459

申请日：2021-11-10

Applicant: BIOGEN MA INC.

Inventor： Wuming Yan ,  Xuan Zhou ,  Xianglin Shi ,  Firoz Antia ,  William F. Kiesman ,  Yannick Fillon

IPC: C07H21/02 ,  C07F7/18 ,  C07D249/06 ,  C07D295/192 ,  C07H23/00 ,  C07H21/04

CPC classification number: C07H21/02 ,  C07F7/1804 ,  C07D249/06 ,  C07D295/192 ,  C07H23/00 ,  C07H21/04

Abstract: The present disclosure describes novel reagents and processes for preparing oligonucleotides, which have two or more nucleotides. In one embodiment, the reagent is represented by Formula I′ or B.

公开(公告)号：US20220348602A1

公开(公告)日：2022-11-03

申请号：US17608802

申请日：2020-05-08

Applicant: BIOGEN MA Inc. ,  AJINOMOTO CO., Inc.

Inventor： Xianglin Shi ,  William F. Kiesman ,  Firoz Antia ,  Yannick Fillon ,  Xuan Zhou ,  Wuming Yan ,  Hong Jiang ,  Hien Nguyen ,  Robert S. Gronke ,  Taisuke Ichimaru ,  Takuya Hamagaki ,  Daisuke Takahashi

IPC: C07H1/02 ,  C07H21/02

Abstract: The present disclosure describes a convergent liquid phase process for manufacturing oligonucleotides by coupling two or more oligonucleotide fragments, each of which have two or more nucleotides. Also provided by the present disclosure are reaction steps involved the convergent liquid phase process.

公开(公告)号：US11142545B2

公开(公告)日：2021-10-12

申请号：US16312819

申请日：2017-06-22

Applicant: BIOGEN MA INC.

Inventor： Xianglin Shi ,  Jimin Yang ,  William F. Kiesman ,  Yannick Fillon

IPC: C07H21/04 ,  C07H1/00 ,  C07H21/02 ,  C07H21/00

Abstract: The invention herein describes a solid-phase synthetic method for preparing thiolated oligonucleotides without needing a capping step. The methods of the invention comprises repetition of a three-reaction per cycle, namely detritylation, coupling and sulfurization, without a capping step. In some embodiments, the synthetic methods of the present invention can be used for preparing an anti-sense oligonucleotide.

公开(公告)号：US20190161513A1

公开(公告)日：2019-05-30

申请号：US16312819

申请日：2017-06-22

Applicant: BIOGEN MA INC.

Inventor： Xianglin Shi ,  Jimin Yang ,  William F. Kiesman ,  Yannick Fillon

IPC: C07H21/04 ,  C07H21/02 ,  C07H1/00

Abstract: The invention herein describes a synthetic method for preparing thiolated oligonucleotides without needing a capping step, as the sulfurization agent caps the unreacted 5′-OH groups.