公开(公告)号：US20180228552A1

公开(公告)日：2018-08-16

申请号：US15883963

申请日：2018-01-30

Applicant: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Thomas E. MILNER ,  Janet ZOLDAN ,  R.Y. Declan FLEMING ,  Nitesh KATTA ,  John RECTOR ,  Michael R. GARDNER ,  Arnold ESTRADA ,  Austin MCELROY ,  Marc D. FELDMAN

IPC: A61B34/20 ,  A61B90/00 ,  A61B5/00 ,  A61B3/10

CPC classification number: A61B34/20 ,  A61B3/102 ,  A61B5/0066 ,  A61B5/6852 ,  A61B5/7264 ,  A61B90/37 ,  A61B2034/2055 ,  A61B2090/364 ,  A61B2090/3735 ,  A61F2009/00851

Abstract: Provided herein are systems, methods and apparatuses for an in vivo surgical device that uses tomographic imaging to guide the process of surgical incisions for cell, biologics and drug delivery; the image guided system guides the process of delivery with comprehensive real-time processing with the ability to seal the location of delivery and offer laser-tissue modification via a co-aligned tissue modification beam on tissue without tissue damage to adjacent critical or delicate structures.

公开(公告)号：US20230149000A1

公开(公告)日：2023-05-18

申请号：US17995865

申请日：2021-04-09

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Thomas E. MILNER ,  Jason B. KING ,  Nitesh KATTA ,  James W. TUNNELL

IPC: A61B10/02 ,  A61B18/22

CPC classification number: A61B10/02 ,  A61B18/22 ,  A61B2018/2266 ,  A61B2018/2205 ,  A61B2018/00761

Abstract: Apparatus and methods for tissue excision. In certain aspects, the apparatus and methods include an annular converging laser beam. The annular converging laser beam can be directed to a surface of a tissue and displace a portion of the tissue in a single or multiple laser pulses. In particular aspects, the dosimetry of the laser beam (e.g. the beam shape, pulse energy and pulse duration) can be controlled to eject the portion of the tissue in a manner to reduce damage to the displaced tissue and the surrounding tissue.

公开(公告)号：US20160150962A1

公开(公告)日：2016-06-02

申请号：US14959379

申请日：2015-12-04

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Marc D. Feldman ,  Thomas E. MILNER ,  Jung-Hwan OH

IPC: A61B5/00 ,  A61B5/145 ,  A61B8/06

CPC classification number: A61B5/0066 ,  A61B5/0073 ,  A61B5/05 ,  A61B5/14546 ,  A61B8/06 ,  A61B8/488

Abstract: A novel contrast mechanism for diagnosing diseased tissue using Ultrasound, Doppler Ultrasonography, Optical Coherence Tomography, or optical Doppler tomography coupled with an externally applied temporally oscillating high-strength magnetic field.

Abstract translation: 一种用于使用超声，多普勒超声，光学相干断层扫描或与外部施加的时间振荡的高强度磁场耦合的光学多普勒断层摄影来诊断患病组织的新型对比机制。

公开(公告)号：US20150265152A1

公开(公告)日：2015-09-24

申请号：US14672928

申请日：2015-03-30

Applicant: Board of Regents, The University of Texas System

Inventor： Marc D. Feldman ,  Thomas E. MILNER ,  Shaochen CHEN ,  Jihoon KIM ,  Li-Hsin HAN ,  Jung Hwan OH ,  Ho LEE

IPC: A61B5/00

CPC classification number: A61B5/0084 ,  A61B1/00183 ,  A61B1/3137 ,  A61B5/0066 ,  A61B5/6852 ,  A61B8/12 ,  A61B8/4461 ,  A61N2007/0091

Abstract: A catheter imaging probe for a patient. The probe includes a conduit through with energy is transmitted. The probe includes a first portion through which the conduit extends. The probe includes a second portion which rotates relative to the conduit to redirect the energy from the conduit. A method for imaging a patient. The method includes the steps of inserting a catheter into the patient. There is the step of rotating a second portion of the catheter relative to a conduit extending through a first portion of the catheter, which redirects the energy transmitted through the conduit to the patient and receives the energy reflected back to the second portion from the patient and redirects the reflected energy to the conduit.

Abstract translation: 用于患者的导管成像探针。 探头包括通过能量传输的导管。 探针包括导管延伸通过的第一部分。 探针包括第二部分，其相对于导管旋转以重新引导来自导管的能量。 一种用于对患者进行成像的方法。 该方法包括将导管插入患者体内的步骤。 存在使导管的第二部分相对于延伸穿过导管的第一部分的导管旋转的步骤，其将通过导管传输的能量重定向到患者并且接收从患者反射回第二部分的能量， 将反射的能量重定向到导管。

公开(公告)号：US20140083970A1

公开(公告)日：2014-03-27

申请号：US14023197

申请日：2013-09-10

Applicant: Board of Regents, The University of Texas System

Inventor： Karthik KUMAR ,  Jonathan C. CONDIT ,  Nathaniel J. KEMP ,  Thomas E. MILNER ,  Xiaojing ZHANG

IPC: G01B11/02

CPC classification number: G02B3/12 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/6852 ,  A61B2562/0233 ,  A61B2562/028 ,  A61B2562/0285 ,  A61B2562/12 ,  B82Y20/00 ,  G01B9/02091 ,  G01B11/02 ,  G01B2290/65 ,  G01N21/4795 ,  G02B3/14 ,  G02B26/0833 ,  G02B26/105 ,  G02B2207/101 ,  G02B2207/109

Abstract: Provided are forward-imaging optical coherence tomography (OCT) systems and probes.

Abstract translation: 提供了前向成像光学相干断层扫描（OCT）系统和探针。

公开(公告)号：US20220211436A1

公开(公告)日：2022-07-07

申请号：US17611315

申请日：2020-05-12

Applicant: Board of Regents, The University of Texas System ,  Research Development Foundation

Inventor： Thomas E. MILNER ,  Nitesh KATTA

IPC: A61B18/20

Abstract: Exemplary embodiments of the present disclosure apparatus and methods that provide for subtractive material processing, including efficient and precise ablation of tissues. Certain embodiments include a first laser configured to direct a first pulse of energy at a first wavelength to a region of tissue; a second laser configured to direct a second pulse of energy at a second wavelength to the region of tissue; and a control system configured to control operation of the first laser and the second laser.