公开(公告)号：US20220211436A1

公开(公告)日：2022-07-07

申请号：US17611315

申请日：2020-05-12

Applicant: Board of Regents, The University of Texas System ,  Research Development Foundation

Inventor： Thomas E. MILNER ,  Nitesh KATTA

IPC: A61B18/20

Abstract: Exemplary embodiments of the present disclosure apparatus and methods that provide for subtractive material processing, including efficient and precise ablation of tissues. Certain embodiments include a first laser configured to direct a first pulse of energy at a first wavelength to a region of tissue; a second laser configured to direct a second pulse of energy at a second wavelength to the region of tissue; and a control system configured to control operation of the first laser and the second laser.

公开(公告)号：US20180158661A1

公开(公告)日：2018-06-07

申请号：US15692167

申请日：2017-08-31

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Livia Schiavinato EBERLIN ,  Thomas MILNER ,  Jialing ZHANG ,  John LIN ,  John RECTOR ,  Nitesh KATTA ,  Aydin ZAHEDIVASH

IPC: H01J49/04 ,  H01J49/00 ,  A61B10/00 ,  B01L3/00 ,  G01N33/487

CPC classification number: H01J49/0431 ,  A61B10/0045 ,  B01L3/0293 ,  B01L3/502 ,  B01L2200/0605 ,  B01L2400/0655 ,  G01N1/02 ,  G01N30/72 ,  G01N33/487 ,  G01N33/574 ,  G01N33/6848 ,  G01N2001/028 ,  G01N2001/4061 ,  G01N2560/00 ,  H01J49/0031 ,  H01J49/04

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

公开(公告)号：US20200279728A1

公开(公告)日：2020-09-03

申请号：US16817728

申请日：2020-03-13

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Livia Schiavinato EBERLIN ,  Thomas MILNER ,  Jialing ZHANG ,  John LIN ,  John RECTOR ,  Nitesh KATTA ,  Aydin ZAHEDIVASH

IPC: H01J49/04 ,  H01J49/00 ,  A61B10/00 ,  G01N33/487 ,  B01L3/00 ,  G01N33/68 ,  G01N1/02 ,  G01N30/72 ,  G01N33/574

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

公开(公告)号：US20180228552A1

公开(公告)日：2018-08-16

申请号：US15883963

申请日：2018-01-30

Applicant: THE BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Thomas E. MILNER ,  Janet ZOLDAN ,  R.Y. Declan FLEMING ,  Nitesh KATTA ,  John RECTOR ,  Michael R. GARDNER ,  Arnold ESTRADA ,  Austin MCELROY ,  Marc D. FELDMAN

IPC: A61B34/20 ,  A61B90/00 ,  A61B5/00 ,  A61B3/10

CPC classification number: A61B34/20 ,  A61B3/102 ,  A61B5/0066 ,  A61B5/6852 ,  A61B5/7264 ,  A61B90/37 ,  A61B2034/2055 ,  A61B2090/364 ,  A61B2090/3735 ,  A61F2009/00851

Abstract: Provided herein are systems, methods and apparatuses for an in vivo surgical device that uses tomographic imaging to guide the process of surgical incisions for cell, biologics and drug delivery; the image guided system guides the process of delivery with comprehensive real-time processing with the ability to seal the location of delivery and offer laser-tissue modification via a co-aligned tissue modification beam on tissue without tissue damage to adjacent critical or delicate structures.

公开(公告)号：US20220196697A1

公开(公告)日：2022-06-23

申请号：US17383981

申请日：2021-07-23

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM ,  BAYLOR COLLEGE OF MEDICINE

Inventor： Livia SCHIAVINATO EBERLIN ,  Thomas MILNER ,  Jialing ZHANG ,  Noah GIESE ,  John LIN ,  Jeffrey R. KUHN ,  James SULIBURK ,  Nitesh KATTA

IPC: G01N35/10 ,  A61B10/04 ,  H01J49/04 ,  A61B10/00 ,  A61B10/02

Abstract: Methods and apparatus are provided for cleaning or exchanging medical devices. Certain embodiments may include a cassette comprising a plurality of medical devices, where the orientation of the cassette can be changed while the cassette is coupled to a processing instrument.

公开(公告)号：US20230149000A1

公开(公告)日：2023-05-18

申请号：US17995865

申请日：2021-04-09

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Thomas E. MILNER ,  Jason B. KING ,  Nitesh KATTA ,  James W. TUNNELL

IPC: A61B10/02 ,  A61B18/22

CPC classification number: A61B10/02 ,  A61B18/22 ,  A61B2018/2266 ,  A61B2018/2205 ,  A61B2018/00761

Abstract: Apparatus and methods for tissue excision. In certain aspects, the apparatus and methods include an annular converging laser beam. The annular converging laser beam can be directed to a surface of a tissue and displace a portion of the tissue in a single or multiple laser pulses. In particular aspects, the dosimetry of the laser beam (e.g. the beam shape, pulse energy and pulse duration) can be controlled to eject the portion of the tissue in a manner to reduce damage to the displaced tissue and the surrounding tissue.

公开(公告)号：US20240387161A1

公开(公告)日：2024-11-21

申请号：US18789936

申请日：2024-07-31

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Livia Schiavinato EBERLIN ,  Thomas MILNER ,  Jialing ZHANG ,  John LIN ,  John RECTOR ,  Nitesh KATTA ,  Aydin ZAHEDIVASH

IPC: H01J49/04 ,  A61B10/00 ,  B01L3/00 ,  B01L3/02 ,  G01N1/02 ,  G01N1/40 ,  G01N30/72 ,  G01N33/487 ,  G01N33/574 ,  G01N33/68 ,  H01J49/00

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissuc sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

公开(公告)号：US20230386815A1

公开(公告)日：2023-11-30

申请号：US18227417

申请日：2023-07-28

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Livia Schiavinato EBERLIN ,  Thomas MILNER ,  Jialing ZHANG ,  John LIN ,  John RECTOR ,  Nitesh KATTA ,  Aydin ZAHEDIVASH

IPC: H01J49/04 ,  H01J49/00 ,  A61B10/00 ,  G01N33/487 ,  B01L3/00 ,  G01N33/68 ,  G01N1/02 ,  G01N30/72 ,  G01N33/574

CPC classification number: H01J49/0431 ,  H01J49/0031 ,  A61B10/0045 ,  G01N33/487 ,  B01L3/502 ,  G01N33/6848 ,  G01N1/02 ,  G01N30/72 ,  H01J49/04 ,  G01N33/574 ,  G01N2560/00 ,  B01L2400/0655 ,  B01L2200/0605 ,  B01L3/0293

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

公开(公告)号：US20220310378A1

公开(公告)日：2022-09-29

申请号：US17566192

申请日：2021-12-30

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Livia Schiavinato EBERLIN ,  Thomas MILNER ,  Jialing ZHANG ,  John LIN ,  John RECTOR ,  Nitesh KATTA ,  Aydin ZAHEDIVASH

IPC: H01J49/04 ,  H01J49/00 ,  A61B10/00 ,  G01N33/487 ,  B01L3/00 ,  G01N33/68 ,  G01N1/02 ,  G01N30/72 ,  G01N33/574

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.

公开(公告)号：US20210257202A1

公开(公告)日：2021-08-19

申请号：US17106445

申请日：2020-11-30

Applicant: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

Inventor： Livia Schiavinato EBERLIN ,  Thomas MILNER ,  Jialing ZHANG ,  John LIN ,  John RECTOR ,  Nitesh KATTA ,  Aydin ZAHEDIVASH

IPC: H01J49/04 ,  H01J49/00 ,  A61B10/00 ,  G01N33/487 ,  B01L3/00 ,  G01N33/68 ,  G01N1/02 ,  G01N30/72 ,  G01N33/574

Abstract: Method and devices are provided for assessing tissue samples from a plurality of tissue sites in a subject using molecular analysis. In certain aspects, devices of the embodiments allow for the collection of liquid tissue samples and delivery of the samples for mass spectrometry analysis.