公开(公告)号：US11452999B2

公开(公告)日：2022-09-27

申请号：US16897994

申请日：2020-06-10

Applicant: Bayer AS

Inventor： Dimitrios Mantzilas ,  Jan Roger Karlson ,  Judit Tjelmeland Østby

IPC: B01J41/05 ,  B01J39/05 ,  B01D15/18 ,  B01D15/36 ,  G21G1/00 ,  B01J49/60 ,  A61K51/00

Abstract: The present invention comprises a method for the generation of 227Th of pharmaceutically tolerable purity comprising i) preparing a generator mixture comprising 227Ac, 227Th and 223Ra; ii) loading said generator mixture onto a strong base anion exchange resin; iii) eluting a mixture of said 223Ra and 227Ac from said strong base anion exchange resin using a first mineral acid in an aqueous solution; iv) eluting 227Th from said strong base anion exchange resin using a second mineral acid in an aqueous solution whereby to generate a first 227Th solution containing contaminant 223Ra and 227Ac; v) loading the first 227Th solution onto a strong acid cation exchange resin; vi) eluting at least a part of the contaminant 223Ra and 227Ac from said strong acid cation exchange resin using a third mineral acid in aqueous solution; and vii) eluting the 227Th from said strong acid cation exchange resin using a first aqueous buffer solution to provide a second 227Th solution. Purified thorium-227 of pharmaceutical purity and a pharmaceutical composition comprising the same are also provided.

公开(公告)号：US10702613B2

公开(公告)日：2020-07-07

申请号：US16066600

申请日：2016-12-29

Applicant: BAYER AS

Inventor： Dimitrios Mantzilas ,  Jan Roger Karlson ,  Judit Tjelmeland Østby ,  Janne Olsen Frenvik

IPC: A61K51/04 ,  A61K51/10 ,  B01D15/36 ,  B01J41/05 ,  A61K51/12 ,  A61K51/06

Abstract: The present invention provides a method for the purification of 227Th from a mixture comprising 227Th and 223Ra, said method comprising: i) preparing a first solution comprising a mixture of 227Th and 223Ra ions dissolved in an aqueous solution of first mineral acid; ii) loading said first solution onto a strong base anion exchange resin; iii) eluting 223Ra from said strong base anion exchange resin using a second mineral acid in an aqueous solution; iv) optionally rinsing said strong base anion exchange resin using a first aqueous medium; v) eluting 227Th from said strong base anion exchange resin using a third mineral acid in an aqueous solution whereby to generate a second solution comprising 227Th. The invention further provides a purified 227Th solution, a corresponding pharmaceutical formulation and methods of treatment of neoplastic disease.