公开(公告)号：US20220034907A1

公开(公告)日：2022-02-03

申请号：US17299660

申请日：2019-12-03

Applicant: Biogen MA Inc.

Inventor： Toby Arlo FERGUSON ,  Danielle LeeZetta GRAHAM ,  Steve Sang-Woo HAN ,  Alexander Reid Vincent MCCAMPBELL ,  Giulio SRUBEK-TOMASSY

IPC: G01N33/68 ,  C12N15/113 ,  A61P25/28 ,  A61K31/7115

Abstract: In one aspect, the invention provides a method for alleviating a symptom in a patient with amyotrophic lateral sclerosis, comprising administering an efficacious therapeutic that is efficacious to the patient, the efficacious therapeutic, when administered to the patient, resulting in a level of a neurofilament protein in a biological sample of the patient that is lower than a level of neurofilament protein in a patient with amyotrophic lateral sclerosis not administered the therapeutic. In some embodiments, the patient is currently being administered with or has formerly been administered with either a non-efficacious therapeutic or a therapeutic that is different than the efficacious therapeutic.