公开(公告)号：US20210363259A1

公开(公告)日：2021-11-25

申请号：US16640422

申请日：2018-08-22

Applicant: Biogen MA Inc.

Inventor： Tia Brie Estey ,  Geetha Govindan ,  Sonal Saluja ,  Kapil Gupta ,  Margaret McGrath

IPC: C07K16/28 ,  A61K47/18 ,  A61K47/26 ,  A61K31/4418 ,  A61K31/496 ,  A61K47/12 ,  A61K47/20

Abstract: Formulations and dosage regimens of an anti-αvβ6 antibody or αvβ6-binding fragment thereof are provided. These formulations find use in the treatment of e.g., fibrosis (e.g., idiopathic pulmonary fibrosis), acute lung injury, and acute kidney injury.

公开(公告)号：US20230116671A1

公开(公告)日：2023-04-13

申请号：US17801196

申请日：2021-02-19

Applicant: BIOGEN MA INC.

Inventor： Robert S. Gronke ,  Jonas P. Immel-Brown ,  Geetha Govindan

IPC: C12N15/113 ,  C12N15/10

Abstract: Disclosed herein are methods for preparing compositions containing oligonucleotides. Methods of this disclosure involve subjecting an aqueous solution of a oligonucleotide to ultrafiltration/diafiltration (UF/DF) in order to form a retentate containing the oligonucleotide, where the ultrafiltration/diafiltration (UF/DF) is carried out using an aqueous buffer solution containing one or more salts. Also disclosed herein are oligonucleotide-containing compositions obtained by these methods.