公开(公告)号：US20220397571A1

公开(公告)日：2022-12-15

申请号：US17705092

申请日：2022-03-25

Applicant: Biogen MA Inc.

Inventor： Leonid GORELIK ,  Kenneth J. SIMON ,  Meena SUBRAMANYAM ,  Mia Marie RUSHE

IPC: G01N33/543

Abstract: The invention relates to methods and reagents for analyzing samples for the presence of JC virus antibodies.

公开(公告)号：US20210102939A1

公开(公告)日：2021-04-08

申请号：US16594843

申请日：2019-10-07

Applicant: Biogen MA Inc.

Inventor： Leonid GORELIK ,  Kenneth J. SIMON ,  Meena SUBRAMANYAM ,  Mia Marie RUSHE

IPC: G01N33/543

Abstract: The disclosure relates to methods and reagents for analyzing samples for the presence of JC virus antibodies. Disclosed is a method that includes obtaining a biological sample from a subject (e.g., plasma, serum, blood, urine, or cerebrospinal fluid), contacting the sample with highly purified viral-like particles (HPVLPs) under conditions suitable for binding of a JCV antibody in the sample to an HPVLP, and detecting the level of JCV antibody binding in the sample to HPVLP. In one embodiment, determining the level of anti-JCV antibodies in the subject sample provides a method of identifying PML risk in a subject.