公开(公告)号：US09471975B2

公开(公告)日：2016-10-18

申请号：US14520837

申请日：2014-10-22

Applicant: Bioptigen, Inc.

Inventor： Ryan Gessner ,  Eric L. Buckland

IPC: G06K9/00 ,  G06T7/00 ,  A61B3/10

CPC classification number: G06T7/0012 ,  A61B3/102

Abstract: Methods of acquiring an image are provided. The methods include deriving a first boundary surface from a volumetric image; deriving a second boundary surface, different and spaced apart from the first boundary surface, of the volumetric image, the first and second boundary surfaces defining a slice of the volumetric image therebetween; and deriving at least one intermediate thin section between the first and second boundary surfaces, the thin section having a thickness that is less than a thickness of the slice of the volumetric image defined by the first and second boundary surfaces. Systems and computer program products are also provided.

Abstract translation: 提供获取图像的方法。 所述方法包括从体积图像导出第一边界表面; 导出与体积图像不同且与第一边界表面不同的第二边界面，第一和第二边界面在它们之间限定体积图像的切片; 并且在所述第一和第二边界表面之间导出至少一个中间薄片部分，所述薄片部分的厚度小于由所述第一和第二边界面限定的所述体积图像的切片的厚度。 还提供系统和计算机程序产品。

公开(公告)号：US10307056B2

公开(公告)日：2019-06-04

申请号：US14561684

申请日：2014-12-05

Applicant: Bioptigen, Inc.

Inventor： Eric L. Buckland ,  Bradley A. Bower ,  Ryan Gessner

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/12

Abstract: Methods of obtaining a measure of blood flow using a Fourier domain optical coherence tomography (FDOCT) system is provided. The method includes obtaining a first optical coherence tomography (OCT) survey scan of a retina of a subject using an OCT scan beam and obtaining a second OCT scan of the retina. The second OCT scan is within an area defined by the obtained first OCT scan and includes a region of retinal blood vessels emerging from and returning to an Optic Nerve Head (ONH) of the retina. An optical phase change is determined from the obtained second OCT scan, the optical phase change being associated with blood flow in a retinal blood vessel in the region of the second OCT scan. An angle of the retinal blood vessel associated with the optical phase change is determined, the angle being measured relative to a direction of transmission of the OCT scan beam. A quantitative measure of vessel blood flow is computed using the optical phase change and the vessel angle relative to the direction of the OCT scan beam.

公开(公告)号：US20150157205A1

公开(公告)日：2015-06-11

申请号：US14561684

申请日：2014-12-05

Applicant: Bioptigen, Inc.

Inventor： Eric L. Buckland ,  Bradley A. Bower ,  Ryan Gessner

IPC: A61B3/12 ,  A61B3/00 ,  A61B3/10

CPC classification number: A61B3/1233 ,  A61B3/0025 ,  A61B3/102

Abstract: Methods of obtaining a measure of blood flow using a Fourier domain optical coherence tomography (FDOCT) system is provided. The method includes obtaining a first optical coherence tomography (OCT) survey scan of a retina of a subject using an OCT scan beam and obtaining a second OCT scan of the retina. The second OCT scan is within an area defined by the obtained first OCT scan and includes a region of retinal blood vessels emerging from and returning to an Optic Nerve Head (ONH) of the retina. An optical phase change is determined from the obtained second OCT scan, the optical phase change being associated with blood flow in a retinal blood vessel in the region of the second OCT scan. An angle of the retinal blood vessel associated with the optical phase change is determined, the angle being measured relative to a direction of transmission of the OCT scan beam. A quantitative measure of vessel blood flow is computed using the optical phase change and the vessel angle relative to the direction of the OCT scan beam.

Abstract translation: 提供了使用傅里叶域光学相干断层扫描（FDOCT）系统获得血流量测量的方法。 该方法包括使用OCT扫描束获得对象的视网膜的第一光学相干断层摄影（OCT）测量扫描并获得视网膜的第二OCT扫描。 第二次OCT扫描在由所获得的第一OCT扫描定义的区域内，并且包括从视网膜的视神经头（ONH）出射并返回到视网膜神经头（ONH）的视网膜血管区域。 从获得的第二OCT扫描确定光学相位变化，光学相位变化与第二OCT扫描区域中的视网膜血管中的血流相关。 确定与光学相位变化相关联的视网膜血管的角度，该角度是相对于OCT扫描束的透射方向被测量的。 使用相对于OCT扫描束的方向的光学相位变化和容器角度来计算血管血流的定量测量。

公开(公告)号：US20150110376A1

公开(公告)日：2015-04-23

申请号：US14520837

申请日：2014-10-22

Applicant: Bioptigen, Inc.

Inventor： Ryan Gessner ,  Eric L. Buckland

IPC: G01B9/02 ,  G06T7/00 ,  A61B3/00 ,  G01B11/28 ,  A61B3/10

CPC classification number: G06T7/0012 ,  A61B3/102

Abstract: Methods of acquiring an image are provided. The methods include deriving a first boundary surface from a volumetric image; deriving a second boundary surface, different and spaced apart from the first boundary surface, of the volumetric image, the first and second boundary surfaces defining a slice of the volumetric image therebetween; and deriving at least one intermediate thin section between the first and second boundary surfaces, the thin section having a thickness that is less than a thickness of the slice of the volumetric image defined by the first and second boundary surfaces. Systems and computer program products are also provided.

Abstract translation: 提供获取图像的方法。 所述方法包括从体积图像导出第一边界表面; 导出与体积图像不同且与第一边界表面不同的第二边界面，第一和第二边界面在它们之间限定体积图像的切片; 并且在所述第一和第二边界表面之间导出至少一个中间薄片部分，所述薄片部分的厚度小于由所述第一和第二边界面限定的所述体积图像的切片的厚度。 还提供系统和计算机程序产品。