公开(公告)号：US10307056B2

公开(公告)日：2019-06-04

申请号：US14561684

申请日：2014-12-05

Applicant: Bioptigen, Inc.

Inventor： Eric L. Buckland ,  Bradley A. Bower ,  Ryan Gessner

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/12

Abstract: Methods of obtaining a measure of blood flow using a Fourier domain optical coherence tomography (FDOCT) system is provided. The method includes obtaining a first optical coherence tomography (OCT) survey scan of a retina of a subject using an OCT scan beam and obtaining a second OCT scan of the retina. The second OCT scan is within an area defined by the obtained first OCT scan and includes a region of retinal blood vessels emerging from and returning to an Optic Nerve Head (ONH) of the retina. An optical phase change is determined from the obtained second OCT scan, the optical phase change being associated with blood flow in a retinal blood vessel in the region of the second OCT scan. An angle of the retinal blood vessel associated with the optical phase change is determined, the angle being measured relative to a direction of transmission of the OCT scan beam. A quantitative measure of vessel blood flow is computed using the optical phase change and the vessel angle relative to the direction of the OCT scan beam.

公开(公告)号：US09867536B2

公开(公告)日：2018-01-16

申请号：US15042592

申请日：2016-02-12

Applicant: Bioptigen, Inc.

Inventor： Joseph A. Izatt ,  Eric L. Buckland ,  Bradley A. Bower ,  Robert H. Hart

IPC: A61B3/10 ,  G01B9/02 ,  A61B3/117 ,  A61B3/12

CPC classification number: A61B3/102 ,  A61B3/117 ,  A61B3/1225 ,  G01B9/0201 ,  G01B9/02078 ,  G01B9/02091

Abstract: Optical coherence tomography systems for imaging a whole eye are provided including a sample arm including focal optics that are configured to rapidly switch between at least two scanning modes in less than about 1.0 second.

公开(公告)号：US09814383B2

公开(公告)日：2017-11-14

申请号：US15464568

申请日：2017-03-21

Applicant: Bioptigen, Inc.

Inventor： Robert H. Hart ,  Eric L. Buckland ,  Glenn A. Myers ,  Joseph A. Izatt ,  Joseph Elliott Vance

IPC: A61B3/14 ,  A61B3/10 ,  G02B26/10

CPC classification number: A61B3/102 ,  A61B5/0066 ,  A61B5/0073 ,  G02B26/105

Abstract: OCT imaging systems are provided for imaging a spherical-type eye including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path. The reference arm path has an associated reference arm path length. A sample is also provided having an associated sample arm path coupled to the source arm and reference arm paths. A lens having a focal power optimized for a diameter of the spherical-type eye is provided along with a reference arm path length adjustment module coupled to the reference arm. The reference arm path length adjustment module is configured to automatically adjust the reference arm path length such that the reference arm path length is based on an eye diameter of the subject.

公开(公告)号：US20170188817A1

公开(公告)日：2017-07-06

申请号：US15464568

申请日：2017-03-21

Applicant: Bioptigen, Inc.

Inventor： Robert H. Hart ,  Eric L. Buckland ,  Glenn A. Myers ,  Joseph A. Izatt ,  Joseph Elliott Vance

IPC: A61B3/10 ,  G02B26/10

CPC classification number: A61B3/102 ,  A61B5/0066 ,  A61B5/0073 ,  G02B26/105

Abstract: OCT imaging systems are provided for imaging a spherical-type eye including a source having an associated source arm path and a reference arm having an associated reference arm path coupled to the source path. The reference arm path has an associated reference arm path length. A sample is also provided having an associated sample arm path coupled to the source arm and reference arm paths. A lens having a focal power optimized for a diameter of the spherical-type eye is provided along with a reference arm path length adjustment module coupled to the reference arm. The reference arm path length adjustment module is configured to automatically adjust the reference arm path length such that the reference arm path length is based on an eye diameter of the subject.

公开(公告)号：US09585556B2

公开(公告)日：2017-03-07

申请号：US15054714

申请日：2016-02-26

Applicant: Bioptigen, Inc.

Inventor： Eric L. Buckland ,  Bradley A. Bower ,  Robert H. Hart ,  Pete Huening

IPC: G01B9/02 ,  A61B3/10 ,  A61B3/14

CPC classification number: A61B3/102 ,  A61B3/14 ,  G01B9/0203 ,  G01B9/02091

Abstract: Systems for imaging a sample are provided. The system includes an OCT imaging portion having an associated OCT path defined by one set of optical elements between an OCT signal delivery optical fiber and the sample; an image capture portion having an associated image capture path defined by a second set of optical elements between an image capture device and the sample; and an illuminator portion having an associated illumination path defined by a third set of optical elements between an illumination source and the sample. The OCT path, the image capture path, and the illuminator path have at least one optical element in common, and the respective paths differ from each other by at least one optical element. The illumination path includes a multi-wavelength source of optical radiation.

Abstract translation: 提供了用于成像样本的系统。 该系统包括OCT成像部分，其具有由OCT信号传送光纤和样本之间的一组光学元件限定的相关OCT路径; 具有由图像捕获装置和样本之间的第二组光学元件限定的相关联的图像捕获路径的图像捕获部分; 以及具有由照明源和样品之间的第三组光学元件限定的相关联的照明路径的照明器部分。 OCT路径，图像捕获路径和照明器路径具有共同的至少一个光学元件，并且相应的路径由至少一个光学元件彼此不同。 照明路径包括多波长的光辐射源。

公开(公告)号：US20160298953A1

公开(公告)日：2016-10-13

申请号：US15190299

申请日：2016-06-23

Applicant: Bioptigen, Inc.

Inventor： Eric L. Buckland ,  Al-Hafeez Z. Dhalla ,  Nestor O. Farmiga ,  Mehran Ghofrani ,  Robert H. Hart ,  Andrew Murnan ,  Christopher Saxer

IPC: G01B9/02 ,  A61B3/10

CPC classification number: G01B9/02087 ,  A61B3/102 ,  G01B9/02004 ,  G01B9/02028 ,  G01B9/02044 ,  G01B9/02091

Abstract: An optical coherence tomography (OCT) system including a source of broadband optical radiation and a beamsplitter coupled to the source is provided. The beamsplitter divides the source radiation into a reference path and a sample path. The reference path includes an optical switch to switch the reference path between a first path having a first reference reflection at a first reference optical path length and a second path having a second reference reflection at a second reference optical path length. The system further includes a beam combiner that mixes source radiation reflected from a subject in the sample path with source radiation returned from the first reference reflection and the second reference reflection. A detection system detects a first wavelength dependent interferogram during the first time interval and a second wavelength dependent interferogram during the second time interval. A processor preconditions the first and second wavelength dependent interferograms.

Abstract translation: 提供了包括宽带光辐射源和耦合到源的分束器的光学相干断层摄影（OCT）系统。 分束器将源辐射分为参考路径和采样路径。 参考路径包括光开关，用于在具有第一参考光路长度的第一参考反射的第一路径和具有第二参考光路长度的第二参考反射的第二路径之间切换参考路径。 该系统还包括一个光束组合器，它将从样本路径中的被摄体反射的源辐射与从第一参考反射和第二参考反射返回的源辐射混合。 检测系统在第一时间间隔期间检测第一波长相关干涉图，并且在第二时间间隔期间检测第二波长相关干涉图。 处理器预处理第一和第二波长依赖干涉图。

公开(公告)号：US20150157205A1

公开(公告)日：2015-06-11

申请号：US14561684

申请日：2014-12-05

Applicant: Bioptigen, Inc.

Inventor： Eric L. Buckland ,  Bradley A. Bower ,  Ryan Gessner

IPC: A61B3/12 ,  A61B3/00 ,  A61B3/10

CPC classification number: A61B3/1233 ,  A61B3/0025 ,  A61B3/102

Abstract: Methods of obtaining a measure of blood flow using a Fourier domain optical coherence tomography (FDOCT) system is provided. The method includes obtaining a first optical coherence tomography (OCT) survey scan of a retina of a subject using an OCT scan beam and obtaining a second OCT scan of the retina. The second OCT scan is within an area defined by the obtained first OCT scan and includes a region of retinal blood vessels emerging from and returning to an Optic Nerve Head (ONH) of the retina. An optical phase change is determined from the obtained second OCT scan, the optical phase change being associated with blood flow in a retinal blood vessel in the region of the second OCT scan. An angle of the retinal blood vessel associated with the optical phase change is determined, the angle being measured relative to a direction of transmission of the OCT scan beam. A quantitative measure of vessel blood flow is computed using the optical phase change and the vessel angle relative to the direction of the OCT scan beam.

Abstract translation: 提供了使用傅里叶域光学相干断层扫描（FDOCT）系统获得血流量测量的方法。 该方法包括使用OCT扫描束获得对象的视网膜的第一光学相干断层摄影（OCT）测量扫描并获得视网膜的第二OCT扫描。 第二次OCT扫描在由所获得的第一OCT扫描定义的区域内，并且包括从视网膜的视神经头（ONH）出射并返回到视网膜神经头（ONH）的视网膜血管区域。 从获得的第二OCT扫描确定光学相位变化，光学相位变化与第二OCT扫描区域中的视网膜血管中的血流相关。 确定与光学相位变化相关联的视网膜血管的角度，该角度是相对于OCT扫描束的透射方向被测量的。 使用相对于OCT扫描束的方向的光学相位变化和容器角度来计算血管血流的定量测量。

公开(公告)号：US20150110376A1

公开(公告)日：2015-04-23

申请号：US14520837

申请日：2014-10-22

Applicant: Bioptigen, Inc.

Inventor： Ryan Gessner ,  Eric L. Buckland

IPC: G01B9/02 ,  G06T7/00 ,  A61B3/00 ,  G01B11/28 ,  A61B3/10

CPC classification number: G06T7/0012 ,  A61B3/102

Abstract: Methods of acquiring an image are provided. The methods include deriving a first boundary surface from a volumetric image; deriving a second boundary surface, different and spaced apart from the first boundary surface, of the volumetric image, the first and second boundary surfaces defining a slice of the volumetric image therebetween; and deriving at least one intermediate thin section between the first and second boundary surfaces, the thin section having a thickness that is less than a thickness of the slice of the volumetric image defined by the first and second boundary surfaces. Systems and computer program products are also provided.

Abstract translation: 提供获取图像的方法。 所述方法包括从体积图像导出第一边界表面; 导出与体积图像不同且与第一边界表面不同的第二边界面，第一和第二边界面在它们之间限定体积图像的切片; 并且在所述第一和第二边界表面之间导出至少一个中间薄片部分，所述薄片部分的厚度小于由所述第一和第二边界面限定的所述体积图像的切片的厚度。 还提供系统和计算机程序产品。

公开(公告)号：US20150103355A1

公开(公告)日：2015-04-16

申请号：US14551916

申请日：2014-11-24

Applicant: Bioptigen, Inc.

Inventor： Bradley A. Bower ,  Robert H. Hart ,  Pete Huening ,  Eric L. Buckland

IPC: A61B3/10 ,  A61B3/14 ,  G01B9/02

CPC classification number: A61B3/102 ,  A61B3/14 ,  G01B9/0203 ,  G01B9/02091

Abstract: Systems for imaging a sample are provided. The system includes an optical coherence tomography (OCT) imaging portion having an associated OCT path defined by one set of optical elements between an OCT signal delivery optical fiber and the sample; an image capture portion having an associated image capture path defined by a second set of optical elements between an image capture device and the sample, different from the OCT path; and an illuminator portion having an associated illumination path defined by a third set of optical elements between an illumination source and the sample. The OCT path, the image capture path, and the illuminator path have at least one optical element in common, and the respective paths differ from each other by at least one optical element. The OCT path and the image capture path share a common intermediate conjugate image plane. Focal control is achieved for the OCT path and the image capture path concurrently through adjustment of one or more common optical elements distal to the common intermediate conjugate plane, such that focal control requires no differential adjustment between optical elements not in common to both paths.

Abstract translation: 提供了用于成像样本的系统。 该系统包括光学相干断层摄影（OCT）成像部分，其具有由OCT信号传送光纤和样本之间的一组光学元件限定的相关OCT路径; 图像捕获部分，具有由图像捕获装置和样本之间的不同于OCT路径的第二组光学元件定义的相关联的图像捕获路径; 以及具有由照明源和样品之间的第三组光学元件限定的相关联的照明路径的照明器部分。 OCT路径，图像捕获路径和照明器路径具有共同的至少一个光学元件，并且相应的路径由至少一个光学元件彼此不同。 OCT路径和图像捕获路径共享一个共同的中间共轭图像平面。 通过调整远离公共中间共轭平面的一个或多个共同的光学元件，通过同时进行OCT路径和图像捕获路径的焦点控制，使得焦点控制不需要在两个路径不共同的光学元件之间进行差分调整。

公开(公告)号：US20150062531A1

公开(公告)日：2015-03-05

申请号：US14471600

申请日：2014-08-28

Applicant: Bioptigen, Inc.

Inventor： Eric L. Buckland

IPC: A61B3/00 ,  G02B27/14 ,  A61B3/10 ,  G02B27/01

CPC classification number: A61B3/005 ,  A61B3/102 ,  A61B3/13 ,  G02B21/0012 ,  G02B27/01 ,  G02B27/0101 ,  G02B27/141 ,  G02B2027/0123 ,  G02B2027/0138

Abstract: Surgical microscope systems are provided including an optical coherence tomography (OCT) system; an objective lens; oculars for direct viewing of a subject distal to the objective lens; a heads up display module configured to direct an optical image through the oculars to be visible to a user of at least one ocular; and a coupling element connected to the surgical microscope coupling the OCT system, the heads up display module and the objective lens. The coupling element has first and second faces, the first face positioned toward the oculars of the surgical microscope and the second face positioned toward the subject. The coupling element is configured to receive a heads up optical display signal at the first face of the coupling element and reflect the signal in a wavelength band of the heads up display module; and receive a signal on the second face of the coupling element and reflect the signal in a wavelength band of the OCT system.

Abstract translation: 提供了包括光学相干断层扫描（OCT）系统的外科显微镜系统; 物镜; 用于直接观看远离物镜的物体的眼睛; 头部显示模块，其被配置为将光学图像引导通过所述眼睛，以对于至少一个眼睛的使用者是可见的; 以及连接到外科显微镜的耦合元件，其耦合OCT系统，抬头显示模块和物镜。 联接元件具有第一和第二面，第一面朝向手术显微镜的眼睛定位，第二面朝向被检体。 耦合元件被配置为在耦合元件的第一面处接收抬头光学显示信号并且在头部显示模块的波长带中反射信号; 并且在耦合元件的第二面上接收信号并将该信号反射在OCT系统的波段中。