公开(公告)号：US20140261454A1

公开(公告)日：2014-09-18

申请号：US13841297

申请日：2013-03-15

Applicant: CAREFUSION 2200, INC.

Inventor： Kenneth M. DOKKEN ,  Tenoch BENITEZ ,  James BARDWELL

IPC: A61K47/32 ,  A61K31/444 ,  A61B19/08 ,  A61K31/155

CPC classification number: A61K47/32 ,  A61B46/40 ,  A61K9/0014 ,  A61K9/7015 ,  A61K31/155 ,  A61K31/444 ,  A61L26/0014 ,  A61L26/0066 ,  A61L2300/404 ,  C08L33/08

Abstract: An antiseptic solution including, a cationic antiseptic agent, a film forming polymer, an anionic tinting agent, and a solvent, wherein the cationic antiseptic agent, the film forming polymer and the anionic tinting agent each remain solubilized within the solution for greater than about 1 hour at 25° C. and 60% relative humidity. The antiseptic agent is preferably octenidine dihydrochloride or chlorhexadine gluconate. The film forming polymer is preferably an acrylate polymer. The solvent is preferably ethanol, isopropanol, and n-propanol. When a drape is adhered to a dried surgical film via the antiseptic solution, the force required to peel the drape from the surgical film is at least about 105 g/25 mm.

Abstract translation: 包括阳离子防腐剂，成膜聚合物，阴离子着色剂和溶剂的防腐溶液，其中阳离子防腐剂，成膜聚合物和阴离子着色剂各自保持溶解在溶液中大于约1 小时在25°C和60％相对湿度。 防腐剂优选为二辛酸二辛酯或葡萄糖酸氯己定。 成膜聚合物优选为丙烯酸酯聚合物。 溶剂优选为乙醇，异丙醇和正丙醇。 当通过防腐溶液将悬垂布贴在干燥的手术膜上时，从手术膜剥离悬垂液所需的力至少约为105克/ 25毫米。

公开(公告)号：US20130236564A1

公开(公告)日：2013-09-12

申请号：US13747165

申请日：2013-01-22

Applicant: CAREFUSION 2200, INC.

Inventor： Scott A. TUFTS ,  James BARDWELL ,  Michael J. BALTEZOR

IPC: A61K33/34

CPC classification number: A61K33/34 ,  A61K31/717 ,  A61L26/0004 ,  A61L26/0023 ,  C08L1/08 ,  Y02P20/582

Abstract: Copper salts of ion exchange materials provide copper ions at levels suitable for use as an anti-infective agent. The copper salts of ion exchange materials may be formed using ether and ester derivatives of cellulose, such as carboxymethyl cellulose (CMC), ethylcellulose (EC), methylcellulose (MC), hydroxypropyl cellulose (HPC), hydroxypropyl methyl cellulose (HPMC), hydroxyethyl methyl cellulose (HEMC), cellulose acetate, and cellulose triacetate. Wound dressings having copper salts of ion exchange materials incorporated therein are also provided, and may be used to reduce the incidence of infection in wounds. The wound dressings may also be used to prevent infections in long-term wounds, such as those formed at wound drain, catheter, and ostomy entry sites. Copper salts of ion exchange materials may be used to kill microorganisms, and may optionally be used with additional anti-infective agents.

Abstract translation: 离子交换材料的铜盐提供适合用作抗感染剂的水平的铜离子。 离子交换材料的铜盐可以使用纤维素的醚和酯衍生物，如羧甲基纤维素（CMC），乙基纤维素（EC），甲基纤维素（MC），羟丙基纤维素（HPC），羟丙基甲基纤维素（HPMC），羟丙基甲基纤维素 甲基纤维素（HEMC），乙酸纤维素和三醋酸纤维素。 还提供了掺入其中的具有离子交换材料的铜盐的伤口敷料，并且可以用于降低伤口感染的发生率。 伤口敷料也可用于预防长期伤口中的感染，例如在伤口排泄，导管和造口术入口部位形成的伤口。 可以使用离子交换材料的铜盐来杀死微生物，并且可以任选地与另外的抗感染剂一起使用。