公开(公告)号：US11406647B2

公开(公告)日：2022-08-09

申请号：US16761631

申请日：2018-11-06

Applicant: COLD SPRING HARBOR LABORATORY ,  DEPYMED, INC.

Inventor： Nicholas Tonks ,  Navasona Krishnan ,  Andreas Grill ,  Howard Sard

IPC: A61K31/58 ,  A61K31/4184

Abstract: Provided is a method of forming a copper-containing complex, including contacting a sample containing copper with a compound of Formula I: wherein R is —OH or —O—CH3. Also provided is a method of inhibiting enzymatic activity of a kinase in a sample, including contacting the sample with a compound of Formula I. Further provided is a method of administering to a subject a pharmaceutical composition including a compound of Formula I optionally complexed with copper. Also provided is a pharmaceutical composition including copper complexed with a compound of Formula I.

公开(公告)号：US12178825B2

公开(公告)日：2024-12-31

申请号：US17866724

申请日：2022-07-18

Applicant: COLD SPRING HARBOR LABORATORY ,  DEPYMED, INC.

Inventor： Nicholas Tonks ,  Navasona Krishnan ,  Andreas Grill ,  Howard Sard

IPC: A61K31/58 ,  A61K31/4184

Abstract: Provided is a method of forming a copper-containing complex, including contacting a sample containing copper with a compound of Formula I: wherein R is —OH or —O—CH3. Also provided is a method of inhibiting enzymatic activity of a kinase in a sample, including contacting the sample with a compound of Formula I. Further provided is a method of administering to a subject a pharmaceutical composition including a compound of Formula I optionally complexed with copper. Also provided is a pharmaceutical composition including copper complexed with a compound of Formula I.