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公开(公告)号：US12215128B2
公开(公告)日：2025-02-04
申请号：US17261313
申请日：2019-07-19
Applicant: COLD SPRING HARBOR LABORATORY , DEPYMED, INC.
Inventor： Nicholas Tonks , Navasona Krishnan , Andreas Grill
IPC: C07D213/38 , C07D401/12 , C07J43/00
Abstract: Compounds of formula: are described herein. The compounds selectively complex copper and are therefore useful both abiotically for measuring and detecting small amounts of copper and, in biological systems, for treating diseases associated with inappropriate copper levels, such as Wilson's disease and gastric cancer.
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公开(公告)号：US11406647B2
公开(公告)日：2022-08-09
申请号：US16761631
申请日：2018-11-06
Applicant: COLD SPRING HARBOR LABORATORY , DEPYMED, INC.
Inventor： Nicholas Tonks , Navasona Krishnan , Andreas Grill , Howard Sard
IPC: A61K31/58 , A61K31/4184
Abstract: Provided is a method of forming a copper-containing complex, including contacting a sample containing copper with a compound of Formula I: wherein R is —OH or —O—CH3. Also provided is a method of inhibiting enzymatic activity of a kinase in a sample, including contacting the sample with a compound of Formula I. Further provided is a method of administering to a subject a pharmaceutical composition including a compound of Formula I optionally complexed with copper. Also provided is a pharmaceutical composition including copper complexed with a compound of Formula I.
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Patent Agency Ranking
公开(公告)号：US12178825B2
公开(公告)日：2024-12-31
申请号：US17866724
申请日：2022-07-18
Applicant: COLD SPRING HARBOR LABORATORY , DEPYMED, INC.
Inventor： Nicholas Tonks , Navasona Krishnan , Andreas Grill , Howard Sard
IPC: A61K31/58 , A61K31/4184
Abstract: Provided is a method of forming a copper-containing complex, including contacting a sample containing copper with a compound of Formula I: wherein R is —OH or —O—CH3. Also provided is a method of inhibiting enzymatic activity of a kinase in a sample, including contacting the sample with a compound of Formula I. Further provided is a method of administering to a subject a pharmaceutical composition including a compound of Formula I optionally complexed with copper. Also provided is a pharmaceutical composition including copper complexed with a compound of Formula I.
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公开(公告)号：US20170296561A1
公开(公告)日：2017-10-19
申请号：US15514415
申请日：2015-09-23
Applicant: Cold Spring Harbor Laboratory
Inventor： Nicholas Tonks , Navasona Krishnan
IPC: A61K31/662 , C12Q1/68
CPC classification number: A61K31/662 , C07F9/3808 , C12Q1/6883 , C12Q2600/156
Abstract: The present invention relates to agents and methods for treating autism spectrum disorders, such as Rett Syndrome. This invention addresses the need mentioned above by providing agents and methods for treating or ameliorating symptoms of neurologic diseases, such as autism spectrum disorders and Rett Syndrome. In one aspect, the invention provides a method for treating a neurologic disease associated with one or more mutations in the MECP2 gene.
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公开(公告)号：US20190247408A1
公开(公告)日：2019-08-15
申请号：US16377875
申请日：2019-04-08
Applicant: Cold Spring Harbor Laboratory
Inventor： Nicholas Tonks , Navasona Krishnan
IPC: A61K31/662 , C12Q1/6883 , C07F9/38
CPC classification number: A61K31/662 , C07F9/3808 , C12Q1/6883 , C12Q2600/156
Abstract: The present invention relates to agents and methods for treating autism spectrum disorders, such as Rett Syndrome.
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公开(公告)号：US20210052614A1
公开(公告)日：2021-02-25
申请号：US17087962
申请日：2020-11-03
Inventor： Stephen J. Benkovic , Nicholas K. Tonks , Chun Yu Liu , Navasona Krishnan , Chunliang Liu
Abstract: A method is disclosed for altering the redox equilibrium of a transmembrane receptor-like protein tyrosine phosphatase (RPTP), particularly a type IIa RPTP, by chemically modulating the activity through contact of such an enzyme with a diaryl boron compound that preferentially reacts with an RPTP in an oxidized state (CyS-OH). This redox modulation is most readily observed and put to use by assaying the inhibition of the phosphatase activity of the RPTP. Such an assay can be carried out on an enzyme in vitro or by contacting the enzyme in a living organism (in vivo). A useful diaryl boron compound corresponds in structure to Formula I in which Ar-1, Ar-2, R1, R2, R3 and R4 are defined within. A pharmaceutical composition containing a useful diaryl boron compound is also disclosed, as are particularly preferred diaryl boron compounds.
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公开(公告)号：US11660306B2
公开(公告)日：2023-05-30
申请号：US16377875
申请日：2019-04-08
Applicant: Cold Spring Harbor Laboratory
Inventor： Nicholas Tonks , Navasona Krishnan
IPC: A61K31/662 , C07F9/38 , C12Q1/6883
CPC classification number: A61K31/662 , C07F9/3808 , C12Q1/6883 , C12Q2600/156
Abstract: The present invention relates to agents and methods for treating autism spectrum disorders, such as Rett Syndrome.
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