公开(公告)号：US11780902B1

公开(公告)日：2023-10-10

申请号：US16517107

申请日：2019-07-19

Applicant: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： Kevin J. Morey ,  June I. Medford

IPC: C07K14/705 ,  G01N33/50 ,  C12N9/12 ,  C12N15/62

CPC classification number: C07K14/705 ,  C12N9/12 ,  C12N15/62 ,  G01N33/5097 ,  C07K2319/035

Abstract: The present disclosure provides compositions and methods for sensing a target substance of interest in the environment and inducing gene expression in response thereto, useful for detection of biological and chemical agents and environmental pollutants.

公开(公告)号：US20230416332A1

公开(公告)日：2023-12-28

申请号：US18340344

申请日：2023-06-23

Applicant: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： Kevin J. Morey ,  June I. Medford

IPC: C07K14/705 ,  C12N15/62 ,  G01N33/50 ,  C12N9/12

CPC classification number: C07K14/705 ,  C12N15/62 ,  G01N33/5097 ,  C12N9/12 ,  C07K2319/035

Abstract: The present disclosure provides compositions and methods for sensing a target substance of interest in the environment and inducing gene expression in response thereto, useful for detection of biological and chemical agents and environmental pollutants.

公开(公告)号：US20180105825A1

公开(公告)日：2018-04-19

申请号：US15787562

申请日：2017-10-18

Applicant: Colorado State University Research Foundation

Inventor： June I. Medford ,  Mauricio S. Antunes ,  Tessema K. Kassaw

IPC: C12N15/82

Abstract: The present disclosure provides synthetic repressor constructs and the proteins encoded therein, as well as synthetic repressible promoter constructs for use in combination with the synthetic repressor constructs/synthetic repressors disclosed herein. Various combinations of synthetic repressor constructs and synthetic repressible promoter constructs are also provided in synthetic genetic circuits for modifying expression of a protein of interest in a plant cell.