公开(公告)号：US20230053833A1

公开(公告)日：2023-02-23

申请号：US17786360

申请日：2019-12-19

Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION

Inventor： John TSANAKTSIDIS ,  Cecily ELDRIDGE ,  Scott COURTNEY

IPC: C07C29/62

Abstract: A process for continuous preparation of halogenated alkoxyethane of general formula XClHC—CF2OR, where X is —Cl or —F and OR is C1-4 alkoxy, the process comprising a step of introducing in a flow reactor reaction components comprising (i) a compound of general formula XClC═CF2, (ii) abase, and (iii) a C1-4 alkanol, wherein a) the flow reactor comprises one or more tubular flow line(s) having an internal cross-sectional area of less than 115 mm2 through which the reaction components flow as a reaction mixture, and b) the halogenated alkoxyethane is formed at least upon the reaction components mixing, with the so formed halogenated alkoxyethane flowing out of the flow reactor in a reactor effluent.

公开(公告)号：US20240317661A1

公开(公告)日：2024-09-26

申请号：US18571585

申请日：2022-06-17

Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION

Inventor： John TSANAKTSIDIS ,  Cecily ELDRIDGE ,  Scott COURTNEY

IPC: C07C41/06 ,  C07C41/42

CPC classification number: C07C41/06 ,  C07C41/42

Abstract: A process for continuous preparation of halogenated alkoxyethane of general formula XClHC—CF2OR, where X is —Cl or —F and OR is C1-4 alkoxy, the process comprising a step of introducing in a plate reactor reaction components comprising (i) a compound of general formula XClC═CF2, (ii) a base, and (iii) a C1-4 alkanol, wherein a) the plate reactor comprises a fluidic module defining one or more fluidic path(s) through which the reaction components flow as a reaction mixture, and b) the halogenated alkoxyethane is formed at least upon the reaction components mixing, with the so formed halogenated alkoxyethane flowing out of the plate reactor in a reactor effluent.

公开(公告)号：US20240286986A1

公开(公告)日：2024-08-29

申请号：US18571528

申请日：2022-06-17

Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION

Inventor： John TSANAKTSIDIS ,  Cecily ELDRIDGE

IPC: C07C41/42

CPC classification number: C07C41/42

Abstract: A process for purifying halogenated alkoxyethane of general formula XClHC—CF2OR, where X is —Cl or —F and OR is C1-4 alkoxy, from a reaction mixture derived from a batch synthetic procedure for producing the halogenated alkoxyethane, the process comprising the steps of: (a) adding one of an amine and an acid to the reaction mixture, (b) adding a polar liquid to the mixture obtained in step a) to induce phase separation and formation of a polar phase and a separate organic phase, the organic phase containing the halogenated alkoxyethane, and (c) adding the other of the amine and the acid not used step (a) to the organic phase obtained in step (b) to thereby purify the halogenated alkoxyethane.

公开(公告)号：US20230041468A1

公开(公告)日：2023-02-09

申请号：US17786048

申请日：2019-12-19

Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION

Inventor： John TSANAKTSIDIS ,  Cecily ELDRIDGE ,  Scott COURTNEY

IPC: C07C41/16 ,  B01J19/18 ,  C07C41/38

Abstract: A process for continuous preparation of halogenated alkoxyethane of general formula XClHC—CF2OR, where X is —Cl or -f and OR is C1-4 alkoxy, the process comprising a step of introducing in a flow reactor reaction components comprising (i) a compound of general formula XClHC—CYF2, where each of X and Y is independently —Cl or —F, (ii) a base, and (iii) a C1-4 alkanol, wherein a) the flow reactor comprises one or more tubular flow line(s) through which the reaction components flow as a reaction mixture, c) the halogenated alkoxyethane is formed at least upon the reaction components mixing, with the so formed halogenated alkoxyethane flowing out of the flow reactor in a reactor effluent, and b) the base is one that forms a salt soluble in the alkanol during formation of the halogenated alkoxyethane.