公开(公告)号：US11098203B2

公开(公告)日：2021-08-24

申请号：US16334650

申请日：2017-08-30

Applicant: COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION

Inventor： Berkay Ozcelik ,  Helmut Werner Thissen

IPC: A61L27/34 ,  C09D5/16 ,  A61L17/14 ,  A61L29/08 ,  C08G59/50 ,  C08G59/18 ,  A61L27/18 ,  A61L29/06 ,  A61L29/16 ,  A61L27/54 ,  C09D163/00 ,  C09D133/26 ,  C09D171/00

Abstract: The application is directed to polymer coatings which can be modified to control biointerfacial interactions including biofilm formation and protein adsorption onto said coatings. The polymer coatings comprise a First Component comprising epoxide or alkenyl groups, and a Second Component comprising at least one amine group. The polymer coatings further comprise at least one bioactive agent which may control said biofilm formation and/or protein adsorption. Also disclosed herein are methods for producing said coatings incorporating bioactive molecules in one or two step procedures on a substrate. The polymer coating may be immobilised on the substrate via the reaction of functional groups present on the First Component and/or Second Component with complimentary functional groups disposed on at least one surface of the substrate.