公开(公告)号：US20160279091A1

公开(公告)日：2016-09-29

申请号：US15172756

申请日：2016-06-03

Applicant: CORNELL UNIVERSITY

Inventor： Hening Lin ,  Bin HE

IPC: A61K31/27

CPC classification number: A61K31/27 ,  A61K31/16 ,  C07C327/42

Abstract: The instant application describes novel compounds that modulate (in particular, inhibit) Sirt2, with structures according to Formulas (1) and (2) provided herein. The invention is also directed to pharmaceutical compositions thereof, methods of treatment (i.e., cancer and neurodegenerative disease) by administration of the modulating compounds, assay methods for finding modulators of Sirt2, and kits for practicing the assay method.

Abstract translation: 本申请描述了使用本文提供的根据式（1）和（2）的结构调节（特别是抑制）Sirt2的新型化合物。 本发明还涉及其药物组合物，通过施用调节化合物的治疗方法（即癌症和神经变性疾病），用于发现Sirt2调节剂的测定方法和用于实施测定方法的试剂盒。