公开(公告)号：US20140293280A1

公开(公告)日：2014-10-02

申请号：US14355655

申请日：2012-11-02

Applicant: CORNING INCORPORATION

Inventor： Glenn Eric Kohnke ,  Xinyuan Liu ,  Marcel Potuzak ,  Alranzo Boh Ruffin ,  Millicent Kaye Weldon Ruffin

IPC: G01J3/44

CPC classification number: G01J3/4412 ,  B82Y30/00 ,  G01N21/658

Abstract: Provided herein are substrates useful for surface-enhanced Raman spectroscopy (SERS), as well as methods of making substrates. The substrates comprise a support element; a nanoparticulate layer; a SERS-active layer in contact with said nanoparticulate layer; and optionally, an immobilizing layer disposed between said nanoparticulate layer and said support element; wherein if the optional immobilizing layer is not present, the nanoparticulate layer is thermally bonded to the support element; and if said optional immobilizing layer is present, said nanoparticulate layer thermally bonded to said immobilizing layer, and optionally, further thermally bonded to said support element. In addition, methods of making the substrates, along with methods of detecting and increasing a Raman signal using the substrates, are described herein.

Abstract translation: 本文提供了可用于表面增强拉曼光谱（SERS）的底物，以及制备底物的方法。 基板包括支撑元件; 纳米颗粒层; 与所述纳米颗粒层接触的SERS活性层; 并且可选地，设置在所述纳米颗粒层和所述支撑元件之间的固定层; 其中如果不存在任选的固定层，则纳米颗粒层热粘合到支撑元件上; 并且如果存在所述任选的固定层，则所述纳米颗粒层热粘合到所述固定层，并且任选地进一步热粘合到所述支撑元件。 此外，本文描述了制造衬底的方法以及使用衬底检测和增加拉曼信号的方法。