公开(公告)号：US20190064736A1

公开(公告)日：2019-02-28

申请号：US16058498

申请日：2018-08-08

Applicant: California Institute of Technology

Inventor： Haowen Ruan ,  Jacob Berlin ,  Tom Haber ,  Changhuei Yang

IPC: G03H1/04 ,  G01N21/47 ,  G01N33/483

Abstract: A magnetic field controlled guidestar for focusing light deep inside scattering media using optical phase conjugation. Compared with the optical and ultrasonic field, the magnetic field has an exceptional penetration depth. The magnetic particle guidestar has a high light-tagging efficiency, good biocompatibility, and a small diameter which enables a sharp and bright focusing deep inside biological tissue. This new method can benefit a wide range of biomedical applications including deep-tissue imaging, neural modulation, and targeted photothermal and photodynamic therapies.

公开(公告)号：US09776242B2

公开(公告)日：2017-10-03

申请号：US15071544

申请日：2016-03-16

Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY

Inventor： Raymond Weitekamp ,  Krishnan Thyagarajan ,  Jacob Berlin ,  Desiree Van Haute

IPC: B22F1/00 ,  G02B5/00 ,  G02F1/01 ,  G02F1/03 ,  B82Y40/00 ,  B29B9/08 ,  A61K9/14

CPC classification number: B22F1/0096 ,  A61K9/14 ,  B22F1/0018 ,  B22F2998/10 ,  B22F2999/00 ,  B29B9/08 ,  B82Y40/00 ,  G02B5/008 ,  G02F1/01 ,  Y02P10/295 ,  B22F1/0022 ,  B22F3/1055 ,  B22F1/0062 ,  B22F7/08 ,  B22F2202/11

Abstract: The present disclosure is directed to processes comprising irradiating an aggregate of chemically bonded or otherwise associated nanoparticles with a light source capable of providing multiphoton excitation, the light source directed at a focal point volume including the aggregate and having sufficient energy to disrupt or fuse the aggregate within the focal point volume to form nanoscale deposits of the nanoparticles.

公开(公告)号：US11156960B2

公开(公告)日：2021-10-26

申请号：US16058498

申请日：2018-08-08

Applicant: California Institute of Technology

Inventor： Haowen Ruan ,  Jacob Berlin ,  Tom Haber ,  Changhuei Yang

IPC: G01N21/47 ,  G03H1/04 ,  G01N33/483 ,  G03H1/22 ,  G03H1/00

Abstract: A magnetic field controlled guidestar for focusing light deep inside scattering media using optical phase conjugation. Compared with the optical and ultrasonic field, the magnetic field has an exceptional penetration depth. The magnetic particle guidestar has a high light-tagging efficiency, good biocompatibility, and a small diameter which enables a sharp and bright focusing deep inside biological tissue. This new method can benefit a wide range of biomedical applications including deep-tissue imaging, neural modulation, and targeted photothermal and photodynamic therapies.