公开(公告)号：US20250152743A1

公开(公告)日：2025-05-15

申请号：US18945412

申请日：2024-11-12

Applicant: California Institute of Technology

Inventor： Michael B. Elowitz ,  Shiyu Xia ,  Andrew C. Lu ,  Lukas Moeller

IPC: A61K48/00 ,  C07K7/06 ,  C12N9/50

Abstract: Disclosed herein include methods, compositions, and kits suitable for use in programmable cell death control. Compositions (e.g., nucleic acid compositions, synthetic protein circuits) provided herein can comprise one or more apoptosis polypeptides; and/or one or more pyroptosis polypeptides; and/or one or more input polypeptides. In some embodiments, expression of a synthetic protein circuit of the disclosure can induce, e.g., apoptosis and/or pyroptosis in a cell.