公开(公告)号：US09019499B2

公开(公告)日：2015-04-28

申请号：US13628304

申请日：2012-09-27

Applicant: Cameron John Tovey

Inventor： Cameron John Tovey

IPC: G01N21/25 ,  H01S3/10 ,  G01J3/10 ,  H01S5/0687 ,  G01N21/39 ,  G01N21/77 ,  G01J3/12

CPC classification number: G01J3/10 ,  G01J2003/1213 ,  G01J2003/1221 ,  G01N21/39 ,  G01N21/7743 ,  H01S5/0687

Abstract: Tunable light source systems and methods with wavelength reference capability are disclosed. A method includes reference filtering a portion of a tunable light beam while the tunable center wavelength λC is tuned over a range by adjusting a wavelength tuning parameter x. The method also includes detecting the reference-filtered tunable light beam and generating therefrom at least one detected light spectrum as a function of the tunable center wavelength λC. The method further includes determining a reference wavelength tuning parameter xCR corresponding to a reference tunable center wavelength λCR based on a maximum value of the at least one detected light spectrum.

Abstract translation: 公开了具有波长参考能力的可调光源系统和方法。 一种方法包括：通过调整波长调谐参数x，将可调谐光束的一部分进行参考滤波，同时可调谐中心波长λC在一个范围内调谐。 该方法还包括检测参考滤波的可调谐光束，并从中产生至少一个检测到的光谱作为可调中心波长λC的函数。 该方法还包括基于至少一个检测到的光谱的最大值来确定对应于参考可调谐中心波长λCR的参考波长调谐参数xCR。

公开(公告)号：US08922858B2

公开(公告)日：2014-12-30

申请号：US13753879

申请日：2013-01-30

Applicant: Cameron John Tovey

Inventor： Cameron John Tovey

IPC: G02B26/12 ,  G02B26/10 ,  G01N21/25 ,  G01N21/77

CPC classification number: G02B26/101 ,  G01N21/253 ,  G01N21/7743

Abstract: A motion control system and a method for biosensor scanning which scans a light beam spot over one or more of the biosensors supported by a microplate with an optical scanner system, the method including: defining a scan path for an optical scanner including selecting axes representing properties of the scan path and selecting a time series, calculating a piecewise polynomial function of time between each point in the time series; and scanning the light beam spot over one or more biosensors according to the defined scan path, as described herein.

Abstract translation: 一种运动控制系统和用于生物传感器扫描的方法，其通过光学扫描器系统扫描由微板支持的一个或多个生物传感器上的光束点，所述方法包括：定义用于光学扫描器的扫描路径，包括选择表示属性的轴 选择时间序列，计算时间序列中每个点之间的时间的分段多项式函数; 并且根据所定义的扫描路径，在一个或多个生物传感器上扫描光束点，如本文所述。

公开(公告)号：US08670121B1

公开(公告)日：2014-03-11

申请号：US13613974

申请日：2012-09-13

Applicant: David Andrew Pastel ,  Cameron John Tovey

Inventor： David Andrew Pastel ,  Cameron John Tovey

IPC: G01N21/25

CPC classification number: G01N21/774

Abstract: A wavelength-tunable detector for use in a label-independent optical reader for reading at least one resonant waveguide grating (RWG) biosensor is disclosed. The wavelength-tunable detector includes a tunable wavelength filter. Broadband light is made incident upon the RWG biosensor to produce resonantly reflected light, which is then passed through the tunable wavelength filter whose central wavelength is adjusted, such as by varying the filter angle of the tunable wavelength filter. This generates filtered resonantly reflected light, which is detected by a photodetector that generates an electrical signal in response thereto. The electrical signal is representative of the detected spectrum, which includes the center resonant wavelength of the RWG biosensor. A controller can be used to determine the center resonant wavelength from the electrical signal.

Abstract translation: 公开了一种用于读取至少一个谐振波导光栅（RWG）生物传感器的标签无关光学读取器中的波长可调检测器。 波长可调检测器包括可调波长滤波器。 宽带光入射到RWG生物传感器上以产生共振的反射光，然后通过调节中心波长的可调谐波长滤波器，例如通过改变可调谐波长滤波器的滤光角度。 这产生滤波的共振反射光，该光被由响应于此产生电信号的光电检测器检测。 电信号表示检测到的光谱，其包括RWG生物传感器的中心谐振波长。 可以使用控制器来确定来自电信号的中心谐振波长。

公开(公告)号：US20130194647A1

公开(公告)日：2013-08-01

申请号：US13753879

申请日：2013-01-30

Applicant: Cameron John Tovey

Inventor： Cameron John Tovey

IPC: G02B26/10

CPC classification number: G02B26/101 ,  G01N21/253 ,  G01N21/7743

Abstract: A motion control system and a method for biosensor scanning which scans a light beam spot over one or more of the biosensors supported by a microplate with an optical scanner system, the method including:defining a scan path for an optical scanner including selecting axes representing properties of the scan path and selecting a time series, calculating a piecewise polynomial function of time between each point in the time series; andscanning the light beam spot over one or more biosensors according to the defined scan path, as described herein.

Abstract translation: 一种运动控制系统和用于生物传感器扫描的方法，其通过光学扫描器系统扫描由微板支持的一个或多个生物传感器上的光束点，所述方法包括：定义用于光学扫描器的扫描路径，包括选择表示属性的轴 选择时间序列，计算时间序列中每个点之间的时间的分段多项式函数; 并且根据所定义的扫描路径，在一个或多个生物传感器上扫描光束点，如本文所述。

公开(公告)号：US20130100462A1

公开(公告)日：2013-04-25

申请号：US13654701

申请日：2012-10-18

Applicant: Ronald Charles Hollenbeck ,  Hak Chuah Sim ,  Cameron John Tovey ,  Cynthia L. Wida

Inventor： Ronald Charles Hollenbeck ,  Hak Chuah Sim ,  Cameron John Tovey ,  Cynthia L. Wida

IPC: G01B11/14

CPC classification number: G01N21/253 ,  G01N2035/00158 ,  G01N2035/0494

Abstract: Optical reader systems and methods with rapid microplate position detection capability are disclosed. The optical reader system includes a scanning optical system configured to scan select position-detecting features to accurately determine the microplate position within the optical reader system. The method includes measuring positions of the position-detecting features in order of their respective amounts of position tolerance, from smallest to largest. The position measurement is carried out for a number of position-detecting features sufficient to determine the microplate position with the optical reader system to within a select microplate position tolerance.

Abstract translation: 公开了具有快速微孔板位置检测能力的光学读取器系统和方法。 光学读取器系统包括扫描光学系统，其被配置为扫描选择位置检测特征以精确地确定光学读取器系统内的微孔板位置。 该方法包括根据它们各自的位置容差量从最小到最大的顺序测量位置检测特征的位置。 对于多个位置检测特征进行位置测量，该特征足以将光学读取器系统的微板位置确定在选择微板位置公差内。

公开(公告)号：US08922860B2

公开(公告)日：2014-12-30

申请号：US13613141

申请日：2012-09-13

Applicant: Cameron John Tovey

Inventor： Cameron John Tovey

IPC: G02B26/08 ,  G01N21/25 ,  G01N21/77

CPC classification number: G01N21/253 ,  G01N21/774 ,  G01N2021/7773 ,  G01N2021/7793 ,  G01N2021/7796 ,  G01N2201/10 ,  G01N2201/1042 ,  G01N2201/105

Abstract: Motion control system and method for biosensor scanning that include inputting to a multi-axis motion controller move commands associated with the scan path as defined by multiple axes. The multiple axes including an x-baseline coordinate x0, a y-baseline coordinate y0, an x-direction oscillation amplitude x1, a y-direction oscillation amplitude y1, an oscillation frequency f and a phase φ. The multi-axis motion controller outputs digital commanded positions for each of the multiple axes. A post-processor receives the commanded positions and generates parameterized commanded positions x and y that each include a baseline motion component and an oscillating motion component. The parameterized commanded positions cause the scanning optical system to deflect the light beam to scan the beam spot over the scan path to scan the biosensor.

Abstract translation: 用于生物传感器扫描的运动控制系统和方法包括向多轴运动控制器输入移动与由多个轴定义的扫描路径相关联的命令。 多个轴包括x基线坐标x0，y基线坐标y0，x方向振荡振幅x1，y方向振荡振幅y1，振荡频率f和相位＆phgr。 多轴运动控制器为每个多轴输出数字指令位置。 后处理器接收命令位置并产生每个包括基线运动分量和振荡运动分量的参数化指令位置x和y。 参数化的命令位置使得扫描光学系统偏转光束以扫描扫描路径上的束斑以扫描生物传感器。

公开(公告)号：US08810804B2

公开(公告)日：2014-08-19

申请号：US13654701

申请日：2012-10-18

Applicant: Ronald Charles Hollenbeck ,  Hak Chuah Sim ,  Cameron John Tovey ,  Cynthia L. Wida

Inventor： Ronald Charles Hollenbeck ,  Hak Chuah Sim ,  Cameron John Tovey ,  Cynthia L. Wida

IPC: G01B11/14

CPC classification number: G01N21/253 ,  G01N2035/00158 ,  G01N2035/0494

Abstract: Optical reader systems and methods with rapid microplate position detection capability are disclosed. The optical reader system includes a scanning optical system configured to scan select position-detecting features to accurately determine the microplate position within the optical reader system. The method includes measuring positions of the position-detecting features in order of their respective amounts of position tolerance, from smallest to largest. The position measurement is carried out for a number of position-detecting features sufficient to determine the microplate position with the optical reader system to within a select microplate position tolerance.

Abstract translation: 公开了具有快速微孔板位置检测能力的光学读取器系统和方法。 光学读取器系统包括扫描光学系统，其被配置为扫描选择位置检测特征以精确地确定光学读取器系统内的微孔板位置。 该方法包括根据它们各自的位置容差量从最小到最大的顺序测量位置检测特征的位置。 对于多个位置检测特征进行位置测量，该特征足以将光学读取器系统的微板位置确定在选择微板位置公差内。

公开(公告)号：US20140071450A1

公开(公告)日：2014-03-13

申请号：US13613974

申请日：2012-09-13

Applicant: David Andrew Pastel ,  Cameron John Tovey

Inventor： David Andrew Pastel ,  Cameron John Tovey

IPC: G01J3/51

CPC classification number: G01N21/774

Abstract: A wavelength-tunable detector for use in a label-independent optical reader for reading at least one resonant waveguide grating (RWG) biosensor is disclosed. The wavelength-tunable detector includes a tunable wavelength filter. Broadband light is made incident upon the RWG biosensor to produce resonantly reflected light, which is then passed through the tunable wavelength filter whose central wavelength is adjusted, such as by varying the filter angle of the tunable wavelength filter. This generates filtered resonantly reflected light, which is detected by a photodetector that generates an electrical signal in response thereto. The electrical signal is representative of the detected spectrum, which includes the center resonant wavelength of the RWG biosensor. A controller can be used to determine the center resonant wavelength from the electrical signal.

Abstract translation: 公开了一种用于读取至少一个谐振波导光栅（RWG）生物传感器的标签无关光学读取器中的波长可调检测器。 波长可调检测器包括可调波长滤波器。 宽带光入射到RWG生物传感器上以产生共振的反射光，然后通过调节中心波长的可调谐波长滤波器，例如通过改变可调波长滤波器的滤光角度。 这产生滤波的共振反射光，该光被由响应于此产生电信号的光电检测器检测。 电信号表示检测到的光谱，其包括RWG生物传感器的中心谐振波长。 可以使用控制器来确定来自电信号的中心谐振波长。

公开(公告)号：US20140085637A1

公开(公告)日：2014-03-27

申请号：US13628304

申请日：2012-09-27

Applicant: Cameron John Tovey

Inventor： Cameron John Tovey

IPC: G01J3/28 ,  G01N21/55

CPC classification number: G01J3/10 ,  G01J2003/1213 ,  G01J2003/1221 ,  G01N21/39 ,  G01N21/7743 ,  H01S5/0687

Abstract: Tunable light source systems and methods with wavelength reference capability are disclosed. A method includes reference filtering a portion of a tunable light beam while the tunable center wavelength λC is tuned over a range by adjusting a wavelength tuning parameter x. The method also includes detecting the reference-filtered tunable light beam and generating therefrom at least one detected light spectrum as a function of the tunable center wavelength λC. The method further includes determining a reference wavelength tuning parameter xCR corresponding to a reference tunable center wavelength λCR based on a maximum value of the at least one detected light spectrum.

Abstract translation: 公开了具有波长参考能力的可调光源系统和方法。 一种方法包括：通过调整波长调谐参数x，将可调谐光束的一部分进行参考滤波，同时可调谐中心波长λC在一个范围内调谐。 该方法还包括检测参考滤波的可调谐光束，并从中产生至少一个检测到的光谱作为可调谐中心波长λC的函数。 该方法还包括基于至少一个检测到的光谱的最大值来确定对应于参考可调谐中心波长λCR的参考波长调谐参数xCR。

公开(公告)号：US20130063724A1

公开(公告)日：2013-03-14

申请号：US13613141

申请日：2012-09-13

Applicant: Cameron John Tovey

Inventor： Cameron John Tovey

IPC: G01B11/00

CPC classification number: G01N21/253 ,  G01N21/774 ,  G01N2021/7773 ,  G01N2021/7793 ,  G01N2021/7796 ,  G01N2201/10 ,  G01N2201/1042 ,  G01N2201/105

Abstract: Motion control system and method for biosensor scanning that include inputting to a multi-axis motion controller move commands associated with the scan path as defined by multiple axes. The multiple axes including an x-baseline coordinate x0, a y-baseline coordinate y0, an x-direction oscillation amplitude x1, a y-direction oscillation amplitude y1, an oscillation frequency f and a phase φ. The multi-axis motion controller outputs digital commanded positions for each of the multiple axes. A post-processor receives the commanded positions and generates parameterized commanded positions x and y that each include a baseline motion component and an oscillating motion component. The parameterized commanded positions cause the scanning optical system to deflect the light beam to scan the beam spot over the scan path to scan the biosensor.

Abstract translation: 用于生物传感器扫描的运动控制系统和方法包括向多轴运动控制器输入移动与由多个轴定义的扫描路径相关联的命令。 多个轴包括x基线坐标x0，y基线坐标y0，x方向振荡振幅x1，y方向振荡振幅y1，振荡频率f和相位＆phgr。 多轴运动控制器为每个多轴输出数字指令位置。 后处理器接收命令位置并产生每个包括基线运动分量和振荡运动分量的参数化指令位置x和y。 参数化的命令位置使得扫描光学系统偏转光束以扫描扫描路径上的束斑以扫描生物传感器。