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    Dosed delivery of autonomic modulation therapy
    1.
    发明授权
    Dosed delivery of autonomic modulation therapy 有权

    公开(公告)号：US11931580B2

    公开(公告)日：2024-03-19

    申请号：US16526750

    申请日：2019-07-30

    Applicant: Cardiac Pacemakers, Inc.

    Inventor： David J. Ternes ,  Jason J. Hamann ,  Stephen B. Ruble ,  Juan Gabriel Hincapie Ordonez ,  Manfred Franke

    IPC: A61N1/372 ,  A61N1/36

    CPC classification number: A61N1/36135 ,  A61N1/36114 ,  A61N1/3727

    Abstract: An example of a method embodiment may include receiving a user programmable neural stimulation (NS) dose for an intermittent neural stimulation (INS) therapy, and delivering the INS therapy with the user programmable NS dose to an autonomic neural target of a patient. Delivering the INS therapy may include delivering NS bursts, and delivering the NS bursts may include delivering a number of NS pulses per cardiac cycle during a portion of the cardiac cycles and not delivering NS pulses during a remaining portion of the cardiac cycles. The method may further include sensing cardiac events within the cardiac cycles, and controlling delivery of the user programmable NS dose of INS therapy using the sensed cardiac events to time delivery of the number of NS pulses per cardiac cycle to provide the user programmable NS dose. The user programmable NS dose may determine the number of NS pulses per cardiac cycle.

    Multi-site CRT capture verification
    4.
    发明授权
    Multi-site CRT capture verification 有权

    公开(公告)号：US10729898B2

    公开(公告)日：2020-08-04

    申请号：US15477635

    申请日：2017-04-03

    Applicant: Cardiac Pacemakers, Inc.

    Inventor： Allan Charles Shuros ,  Yinghong Yu ,  David J. Ternes ,  Michael J. Kane ,  William J. Linder

    IPC: A61N1/00 ,  A61N1/365 ,  A61N1/362 ,  A61N1/36 ,  A61N1/18

    Abstract: An apparatus comprises a cardiac signal sensing circuit configured for coupling electrically to a plurality of electrodes and to sense intrinsic cardiac activation at three or more locations within a subject's body using the electrodes; a stimulus circuit configured for coupling to the plurality of electrodes; a signal processing circuit electrically coupled to the cardiac signal sensing circuit and configured to determine a baseline intrinsic activation vector according to the sensed intrinsic cardiac activation; and a control circuit electrically coupled to the cardiac signal sensing circuit and stimulus circuit and configured to: initiate delivery of electrical pacing therapy using initial pacing parameters determined according to the baseline intrinsic activation vector; initiate sensing of a paced activation vector; and adjust one or more pacing therapy parameters according to the paced activation vector.

    ATRIOVENTRICULAR CONDUCTION GUIDED HIS-BUNDLE PACING
    5.
    发明申请
    ATRIOVENTRICULAR CONDUCTION GUIDED HIS-BUNDLE PACING 审中-公开

    公开(公告)号：US20200179705A1

    公开(公告)日：2020-06-11

    申请号：US16707550

    申请日：2019-12-09

    Applicant: Cardiac Pacemakers, Inc.

    Inventor： David J. Ternes ,  Deepa Mahajan

    IPC: A61N1/365 ,  A61N1/368 ,  A61N1/37

    Abstract: Systems and methods for dynamically controlling HBP delivery based on patient AV conduction status are disclosed. An exemplary medical system includes an electrostimulation circuit to generate HBP pulses to stimulate a His bundle or a bundle branch of the heart. An AV conduction monitor circuit continuously or periodically assesses AV conduction status, and detects an indication of presence or absence of AV conduction abnormality. If an AV conduction abnormality is indicated, a control circuit may control the electrostimulation circuit to deliver the HBP pulses. Ventricular backup pacing may be delivered if HBP fails to capture and elicit ventricular activation. When the AV conduction become normal, the control circuit may withhold HBP delivery and promote patient intrinsic ventricular activation.

    SYSTEMS AND METHODS FOR DYNAMIC CONTROL OF HEART FAILURE THERAPY
    7.
    发明申请
    SYSTEMS AND METHODS FOR DYNAMIC CONTROL OF HEART FAILURE THERAPY 审中-公开

    公开(公告)号：US20180361162A1

    公开(公告)日：2018-12-20

    申请号：US16007094

    申请日：2018-06-13

    Applicant: Cardiac Pacemakers, Inc.

    Inventor： David J. Ternes ,  Yinghong Yu ,  Jason Humphrey ,  David L. Perschbacher ,  Michael James Dufresne ,  Adam MacEwen ,  Keith L. Herrmann

    IPC: A61N1/365 ,  A61N1/372 ,  A61N1/378 ,  A61N1/39 ,  A61N1/362 ,  A61N1/37

    Abstract: Systems and methods for monitoring and treating patients with heart failure (HF) are discussed. The system may sense cardiac signals, and receives information about patient physiological or functional conditions. A stimulation parameter table that includes recommended values of atrioventricular delay (AVD) or other timing parameters maybe created at a multitude of patient physiological or functional conditions. The system may periodically reassess patient physiological or functional conditions. A therapy programmer circuit may dynamically switch between left ventricular-only pacing and biventricular pacing, or switch between single site pacing and multisite pacing based on the patient condition. The therapy programmer circuit may adjust AVD and other timing parameters using the cardiac signal input and the stored stimulation parameter table. A HF therapy may be delivered according to the determined stimulation site, stimulation mode, and the stimulation timing.

    EXTERNAL AUDIT OF IMPLANTABLE MEDICAL DEVICE
    8.
    发明申请
    EXTERNAL AUDIT OF IMPLANTABLE MEDICAL DEVICE 审中-公开

    公开(公告)号：US20180078778A1

    公开(公告)日：2018-03-22

    申请号：US15675427

    申请日：2017-08-11

    Applicant: Cardiac Pacemakers, Inc.

    Inventor： David J. Ternes ,  Pramodsingh Hirasingh Thakur ,  Stephen B. Ruble

    IPC: A61N1/372 ,  A61N1/37

    Abstract: Systems and methods for auditing an operation of an ambulatory medical device (AMD) are described. A system may include an auditor device and an analyzer circuit communicatively coupled to each other. The auditor device can sense from the patient, independently of and during the operation of the AMD, information about the operation of the AMD including sensed electrostimulation and a physiological signal in response to the electrostimulation. The analyzer unit may generate a device audit indicator indicating the functionality and performance of the AMD using the sensed physiological signal and the sensed AMD operation information. The system may output the device audit indicator to a user or a process, or to program device therapy for the AMD based on the device audit indicator.

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