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公开(公告)号：US11577083B2
公开(公告)日：2023-02-14
申请号：US17165678
申请日：2021-02-02
Applicant: Cardiac Pacemakers, Inc.
Inventor： Juan Gabriel Hincapie Ordonez , David J. Ternes , Jason J. Hamann , Stephen B. Ruble
Abstract: A neurostimulation system provides for capture verification and stimulation intensity adjustment to ensure effectiveness of vagus nerve stimulation in modulating one or more target functions in a patient. In various embodiments, stimulation is applied to the vagus nerve, and evoked responses are detected to verify that the stimulation captures the vagus nerve and to adjust one or more stimulation parameters that control the stimulation intensity.
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公开(公告)号：US10940316B2
公开(公告)日：2021-03-09
申请号：US16178106
申请日：2018-11-01
Applicant: Cardiac Pacemakers, Inc.
Inventor： Juan Gabriel Hincapie Ordonez , David J. Ternes , Jason J. Hamann , Stephen B. Ruble
Abstract: A neurostimulation system provides for capture verification and stimulation intensity adjustment to ensure effectiveness of vagus nerve stimulation in modulating one or more target functions in a patient. In various embodiments, stimulation is applied to the vagus nerve, and evoked responses are detected to verify that the stimulation captures the vagus nerve and to adjust one or more stimulation parameters that control the stimulation intensity.
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公开(公告)号：US10668287B2
公开(公告)日：2020-06-02
申请号：US15660384
申请日：2017-07-26
Applicant: Cardiac Pacemakers, Inc.
Inventor： Andrew P. Kramer , Jason J. Hamann
Abstract: In various method embodiments for operating an implantable neural stimulator to deliver a neural stimulation therapy to an autonomic neural target, the method comprises using the implantable neural stimulator to deliver the neural stimulation therapy to the autonomic neural target, and evaluating an evoked response to the neural stimulation bursts. The neural stimulation therapy includes a plurality of neural stimulation bursts where each neural stimulation burst includes a plurality of neural stimulation pulses and successive neural stimulation bursts are separated by a time without neural stimulation pulses. Evaluating the evoked response includes sensing the evoked response to the neural stimulation bursts where sensing the evoked response includes sensing at least one physiological parameter affected by the neural stimulation bursts, comparing the sensed evoked response against a baseline, and determining if the evoked response substantially returns to the baseline between neural stimulation bursts.
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公开(公告)号：US20200086113A1
公开(公告)日：2020-03-19
申请号：US16591263
申请日：2019-10-02
Applicant: Cardiac Pacemakers, Inc.
Inventor： Manfred Franke , David J. Ternes , Juan Gabriel Hincapie Ordonez , Stephen B. Ruble , Jason J. Hamann , Kevin J. Mohsenian , Jack Gordon
IPC: A61N1/05
Abstract: A neural stimulation system delivers neural stimulation to a target nerve with control of direction of propagation of evoked neural signals in one or more fiber types of the target nerve using electrode configuration, thereby providing effective therapy while minimizing unintended effects. In various embodiments, mechanical parameters of a multi-polar electrode are determined to provide directed propagation of the neural stimulation by effecting neural conduction block in or near the stimulation site. In various embodiments, the electrode includes a cathode for evoking action potentials and a plurality of anodes for blocking the propagation of the evoked action potentials in specified direction(s) and fiber type(s) while minimizing the formation of virtual cathodes.
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公开(公告)号：US10413731B2
公开(公告)日：2019-09-17
申请号：US14597145
申请日：2015-01-14
Applicant: Cardiac Pacemakers, Inc.
Inventor： Manfred Franke , David J. Ternes , Juan Gabriel Hincapie Ordonez , Stephen B. Ruble , Jason J. Hamann
IPC: A61N1/00 , A61N1/36 , A61N1/05 , A61B18/12 , A61B18/00 , A61N1/372 , A61N1/378 , A61B18/14 , A61B18/20
Abstract: An example of a system may include a stimulator and at least one controller. The stimulator may be configured to deliver nerve stimulation to capture a first set of axons in a nerve and to deliver depletion block stimulation to capture a second set of axons in the nerve, where the second set is a subset of the first. The depletion block stimulation may include a series of pulses at a depletion pulse frequency within a range between about 100 Hz to about 1 kHz, and the nerve stimulation may include a series of pulses at a stimulation pulse frequency within a range of about 0.25 Hz to about 50 Hz. At least a portion of the nerve stimulation and at least a portion of the depletion block stimulation may be delivered to be effective in providing a nerve block while delivering nerve stimulation.
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Patent Agency Ranking
公开(公告)号：US10201709B2
公开(公告)日：2019-02-12
申请号：US14597137
申请日：2015-01-14
Applicant: Cardiac Pacemakers, Inc.
Inventor： Manfred Franke , David J. Ternes , Juan Gabriel Hincapie Ordonez , Stephen B. Ruble , Jason J. Hamann , Arjun D. Sharma
Abstract: An example of a system may include a depletion block neural stimulator and a depletion block controller. The depletion block neural stimulator may be configured to deliver a depletion block stimulation to a nerve. The depletion block stimulation may include a series of pulses at a pulse frequency within a range between about 100 Hz to about 1000 Hz. The depletion block controller may be configured to communicate with the depletion block neural stimulator and control the depletion block stimulation. The depletion block controller may be configured to receive a start depletion block signal and respond to the received start depletion block signal by initiating the delivery of the depletion block stimulation to the nerve, and the depletion block controller may be configured to receive a stop depletion block signal and respond to the received stop depletion block signal by terminating the delivery of the depletion block stimulation to the nerve.
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公开(公告)号：US20180050207A1
公开(公告)日：2018-02-22
申请号：US15658139
申请日：2017-07-24
Applicant: Cardiac Pacemakers, Inc.
Inventor： Jason J. Hamann , David J. Ternes , Stephen B. Ruble , Juan Gabriel Hincapie Ordonez
IPC: A61N1/36
CPC classification number: A61N1/36135 , A61N1/36053 , A61N1/36114 , A61N1/36167
Abstract: A neurostimulation system delivers neurostimulation to a patient using one or more primary parameters and one or more secondary parameters. The one or more primary parameters are controlled for maintaining efficacy of the neurostimulation.The one or more secondary parameters are adjusted for preventing the patient from developing neural accommodation. In various embodiments, values for the one or more secondary parameters are varied during the delivery of the neurostimulation for prevention of neural accommodation that may result from a constant or periodic pattern of stimulation pulses.
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公开(公告)号：US09731135B2
公开(公告)日：2017-08-15
申请号：US14733160
申请日：2015-06-08
Applicant: Cardiac Pacemakers, Inc.
Inventor： Shantha Arcot-Krishnamurthy , David J. Ternes , Jason J. Hamann , Juan Gabriel Hincapie Ordonez , Stephen B. Ruble
CPC classification number: A61N1/36139 , A61N1/36053 , A61N1/36128 , A61N1/36146 , A61N1/36185 , A61N1/37235 , A61N1/37288
Abstract: A neurostimulation system includes a neural stimulation lead having a proximal portion and a distal portion and including a plurality of electrodes along the distal portion. The plurality of electrodes are configured for positioning proximate a portion of the autonomic nervous system. A neural stimulation circuit, coupled to the plurality of electrodes, delivers neural stimulation pulses to the plurality of electrodes. A processor and controller is configured to control the neural stimulation circuit to deliver first neural stimulation pulses to each of a plurality of electrode configurations. Each electrode configuration includes one or more of the plurality of electrodes. The processor and controller is further configured to receive information related to motor fiber activity that is induced in response to delivery of the first neural stimulation pulses to each of the plurality of electrode configurations and to identify the electrode configurations that induce the motor fiber activity.
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公开(公告)号：US20170036027A1
公开(公告)日：2017-02-09
申请号：US15278186
申请日：2016-09-28
Applicant: Cardiac Pacemakers, Inc.
Inventor： Weiying Zhao , Quan Ni , Stephen B. Ruble , Jason J. Hamann
CPC classification number: A61N1/36114 , A61N1/0551 , A61N1/36053 , A61N1/36117 , A61N1/36592 , A61N1/3712
Abstract: According to various method embodiments, a person is indicated for a therapy to treat a cardiovascular disease, and the therapy is delivered to the person to treat the cardiovascular disease. Delivering the therapy includes delivering a vagal stimulation therapy (VST) to a vagus nerve of the person at a therapeutically-effective intensity for the cardiovascular disease that is below an upper boundary at which upper boundary the VST would lower an intrinsic heart rate during the VST.
Abstract translation: 根据各种方法实施例，指示一个人用于治疗心血管疾病的治疗，并且将该治疗递送给该人以治疗心血管疾病。 提供治疗包括将迷走神经刺激治疗（VST）以对于心血管疾病的治疗有效强度的人的迷走神经递送，所述心血管疾病低于VST在VST期间的上边界降低内在心率的上边界 。
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公开(公告)号：US09399136B2
公开(公告)日：2016-07-26
申请号：US14666996
申请日：2015-03-24
Applicant: Cardiac Pacemakers, Inc.
Inventor： Jason J. Hamann , Scott Vanderlinde , David J. Ternes
IPC: A61N1/36 , A61N1/378 , A61N1/37 , A61N1/372 , A61N1/39 , A61B5/00 , H01M10/48 , H02J7/00 , G01R31/36
CPC classification number: A61N1/36142 , A61B5/0006 , A61B2560/0204 , A61N1/3605 , A61N1/36053 , A61N1/36139 , A61N1/36146 , A61N1/3708 , A61N1/37276 , A61N1/378 , A61N1/3787 , A61N1/3962 , A61N1/3975 , G01R31/3606 , H01M10/48 , H02J7/0047 , H02J7/0063 , H02J2007/005 , H02J2007/0067
Abstract: An implantable medical device is powered by a battery to deliver one or more therapies including at least one non-life-sustaining therapy such as neural stimulation for enhancing quality of life of a patient. When the battery approaches its end of life, the implantable medical device reduces power consumption of the neural stimulation (e.g., intensity of the neural stimulation) for extending the remaining battery life while maintaining a certain amount of therapeutic benefits for the patient. In one embodiment, the intensity of the neural stimulation is reduced in a tiered manner. In one embodiment in which the implantable medical device also delivers at least one life-sustaining cardiac stimulation therapy, the neural stimulation is disabled or adjusted to reduce its power consumption (e.g., intensity) while the intensity of the cardiac stimulation therapy is maintained when the battery is near its end of life.
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