公开(公告)号：US12180507B2

公开(公告)日：2024-12-31

申请号：US15749733

申请日：2016-08-05

Applicant: Colorado State University Research Foundation

Inventor： Salman R. Khetani ,  Mitchell J. Durham ,  Brenton R. Ware

IPC: C12N5/00 ,  A61K35/407 ,  A61K35/44 ,  C12N5/071 ,  G01N33/50

Abstract: The disclosure relates to in vitro cultures of human hepatocytes, and in particular co-cultures systems including human hepatocytes, non-parenchymal cells, and human endothelial cells, and the use of the co-cultures in developing and screening drugs.

公开(公告)号：US20180223253A1

公开(公告)日：2018-08-09

申请号：US15749733

申请日：2016-08-05

Applicant: Colorado State University Research Foundation

Inventor： Salman R. Khetani ,  Mitchell J. Durham ,  Brenton R. Ware

IPC: C12N5/071 ,  A61K35/407 ,  A61K35/44 ,  G01N33/50

Abstract: The disclosure relates to in vitro cultures of human hepatocytes, and in particular co-cultures systems including human hepatocytes, non-parenchymal cells, and human endothelial cells, and the use of the co-cultures in developing and screening drugs.