公开(公告)号：US20150118703A1

公开(公告)日：2015-04-30

申请号：US14486210

申请日：2014-09-15

Applicant: DALIAN UNIVERSITY OF TECHNOLOGY

Inventor： Xiaojun PENG ,  SI ZHANG ,  JIANGLI FAN ,  JINGYUN WANG

IPC: G01N33/52 ,  C07D215/10 ,  C07D277/64 ,  C07D417/06

CPC classification number: C07D277/64 ,  C07D215/10 ,  C07D417/06 ,  G01N1/30

Abstract: The present invention provides a category of cyano-substituted asymmetric cyanine dyes having the following general structural Formula I and its synthesizing method. The cyano-substituted asymmetric cyanine dyes in present invention are easily synthesized and have long emission wavelength, high molar extinction coefficient, high sensitivity, good light stability, high fluorescence quantum yield after binding with nucleic acid, and low cell toxicity, which is beneficial for application as fluorescent dyes and could also be used in the field of identifying nucleic acid molecules, clinical diagnostics, and immunoassay testing etc.

Abstract translation: 本发明提供一类具有以下通式结构式I及其合成方法的氰基取代的不对称花青染料。 本发明中氰基取代的不对称花青染料易于合成，具有长发射波长，高摩尔消光系数，高灵敏度，良好的光稳定性，与核酸结合后的高荧光量子产率，低细胞毒性，有利于 作为荧光染料的应用，也可用于鉴定核酸分子，临床诊断和免疫测定等领域。

公开(公告)号：US20130276667A1

公开(公告)日：2013-10-24

申请号：US13919996

申请日：2013-06-17

Applicant: ZHUHAI NINESTAR MANAGEMENT CO., LTD. ,  DALIAN UNIVERSITY OF TECHNOLOGY

Inventor： XIAOJUN PENG ,  JINHE WU ,  ZHI LONG ,  RONG ZHANG ,  LICHENG WANG ,  FENG WANG ,  SHAOLEI LI ,  JIANGLI FAN ,  FENGLING SONG ,  SHIGUO SUN

IPC: C09D11/00

CPC classification number: C09D11/328 ,  C07D221/18 ,  C09B5/14 ,  C09B67/0034 ,  C09B67/0038 ,  C09D5/028 ,  C09D7/41

Abstract: The present invention relates to compounds shown in the general formula (I) or (III), the salts thereof or their mixtures, as well as their preparation method and application. In the general formula (I), X1 is H or CO2H; X2 is OH or phenyl group with 0-2 sulfonic acid substituents, and the sulfonic acid substituents are located at random positions of a benzene ring; when X2 is OH, X1 is H; when X2 is phenyl group with 0-2 sulfonic acid substituents, X1 is H or CO2H; n is an integer of 0-2; and in the general formula (III), n and m are respectively an integer of 0-2. The compounds and the mixtures not only have improved light resistance, ozone resistance and water resistance, but also have excellent water solubility and long-term stability in ink-jet ink.

Abstract translation: 本发明涉及通式（I）或（III）所示的化合物，其盐或其混合物及其制备方法和应用。 在通式（I）中，X 1为H或CO 2 H; X2是OH或具有0-2个磺酸取代基的苯基，磺酸取代基位于苯环的随机位置; 当X2是OH时，X1是H; 当X2是具有0-2个磺酸取代基的苯基时，X 1是H或CO 2 H; n是0-2的整数; 在通式（III）中，n和m分别为0-2的整数。 化合物和混合物不仅具有改进的耐光性，耐臭氧性和耐水性，而且在喷墨油墨中也具有优异的水溶性和长期稳定性。