BORON-DIPYRROMETHENE FLUORESCENCE PROBES AND MANUFACTURING METHOD AND USE THEREOF
    2.
    发明申请
    BORON-DIPYRROMETHENE FLUORESCENCE PROBES AND MANUFACTURING METHOD AND USE THEREOF 有权
    硼 - 二氯乙烯荧光探针及其制造方法及其应用

    公开(公告)号:US20170029444A1

    公开(公告)日:2017-02-02

    申请号:US15039674

    申请日:2014-11-26

    Abstract: The present invention provides a difluoroboron dipyrromethene fluorescent probe having a structure represented by the following general formula I, and a production method and an application thereof. Said difluoroboron dipyrromethene fluorescent probe exhibits low background fluorescence, and a rapid and significant fluorescence enhancement up to 100 times after the addition of hypochloric acid. The fluorescent intensity of said fluorescent probe shows a good linear relation with the concentration of hypochloric acid in a nanomole level, and the detection limit thereof is 0.56 nanomole. Said fluorescent probe has good selectivity since it hardly responds to other reactive oxygen species such as H2O2, O2−, TBHP, HO., TBO., 1O2 and NO., and is not interfered by pH in a wide range. Said fluorescent probe can be applied to detect hypochloric acid in living cells.

    Abstract translation: 本发明提供具有由以下通式I表示的结构的二氟硼烷二吡咯亚甲基荧光探针及其制备方法和应用。 所述二氟硼酸二吡咯亚甲基荧光探针显示低背景荧光,并且在加入次氯酸之后快速且显着的荧光增强达100倍。 所述荧光探针的荧光强度与纳摩尔浓度的次氯酸浓度呈良好的线性关系,其检出限为0.56纳摩尔。 所述荧光探针具有良好的选择性,因为它几乎不响应其它活性氧物质如H 2 O 2,O 2 - ,TBHP,HO·,TBO·,1 O 2和NO-,并且不受宽泛的pH的干扰 范围。 所述荧光探针可用于检测活细胞中的次氯酸。

    PHOTOSENSITIZER AND DERIVATIVES AND APPLICATION THEREOF

    公开(公告)号:US20210030873A1

    公开(公告)日:2021-02-04

    申请号:US16633087

    申请日:2017-11-24

    Abstract: A photosensitizer and derivative, application thereof. The photosensitizer has the structure of general formula I, wherein X is S or Se, Y is organic or inorganic ion, R1 and R2 are independently selected from H, alkyl, alkoxy, alkyl amido, alkyl azide and the like; R3 is selected from H, alkyl, alkoxy, amino sulfonyl, hydroxyl, carboxyl and the like, and L1 is a linker selected from —(CH2)n1— or —(CH2CH2O)n2—. The derivatives are molecular medicines with drug molecules of anticancer and chemotherapy or tumor targeting function connected to the said photosensitizer. The photosensitizer has excellent near infrared characteristics and low dark toxicity and is used in the field of photodynamic tumor therapy. The introduction of benzophenothiazine or benzophenoselenazine into derivatives with tumor-targeting function could improve the specific uptake of photosensitizer in tumor tissues. Moreover, clinical anticancer drugs can be introduced into the structure of benzophenothiazine or benzophenoselenazine to achieve the purpose of combining therapy of photodynamic therapy and chemotherapy.

    CLASS OF CYANO-SUBSTITUTED ASYMMETRIC CYANINE DYES, SYNTHESIZING METHOD AND APPLICATION THEREOF
    5.
    发明申请
    CLASS OF CYANO-SUBSTITUTED ASYMMETRIC CYANINE DYES, SYNTHESIZING METHOD AND APPLICATION THEREOF 审中-公开
    氰基取代的不对称氰基染料类,合成方法及其应用

    公开(公告)号:US20150118703A1

    公开(公告)日:2015-04-30

    申请号:US14486210

    申请日:2014-09-15

    CPC classification number: C07D277/64 C07D215/10 C07D417/06 G01N1/30

    Abstract: The present invention provides a category of cyano-substituted asymmetric cyanine dyes having the following general structural Formula I and its synthesizing method. The cyano-substituted asymmetric cyanine dyes in present invention are easily synthesized and have long emission wavelength, high molar extinction coefficient, high sensitivity, good light stability, high fluorescence quantum yield after binding with nucleic acid, and low cell toxicity, which is beneficial for application as fluorescent dyes and could also be used in the field of identifying nucleic acid molecules, clinical diagnostics, and immunoassay testing etc.

    Abstract translation: 本发明提供一类具有以下通式结构式I及其合成方法的氰基取代的不对称花青染料。 本发明中氰基取代的不对称花青染料易于合成,具有长发射波长,高摩尔消光系数,高灵敏度,良好的光稳定性,与核酸结合后的高荧光量子产率,低细胞毒性,有利于 作为荧光染料的应用,也可用于鉴定核酸分子,临床诊断和免疫测定等领域。

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