公开(公告)号：US12196709B2

公开(公告)日：2025-01-14

申请号：US17758646

申请日：2021-01-14

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： John Lawrence Campbell ,  Brendon Seale

IPC: G01N27/624 ,  G01N27/623

Abstract: A DMS device receives a curtain gas that includes a chemical modifier into its curtain plate. Before or while receiving ions of an analyte, the DMS device steps the CoV through a series of values in order to apply different CoV values to at least one precursor ion derived from the chemical modifier. For each CoV value of the series of values, a mass spectrometer selects and mass analyzes the at least one precursor ion. An intensity is produced for each CoV value of the series of values. An intensity versus CoV value peak is calculated from the intensities measured. A representative CoV value is calculated for the peak. The difference between the representative CoV value and known CoV values that represent an uncontaminated curtain plate is calculated. If the difference is greater than or equal to a predetermined threshold value, the curtain plate is determined to be contaminated.

公开(公告)号：US20230084101A1

公开(公告)日：2023-03-16

申请号：US17758646

申请日：2021-01-14

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： John Lawrence Campbell ,  Brendon Seale

IPC: G01N27/624 ,  G01N27/623

Abstract: A DMS device receives a curtain gas that includes a chemical modifier into its curtain plate. Before or while receiving ions of an analyte, the DMS device steps the CoV through a series of values in order to apply different CoV values to at least one precursor ion derived from the chemical modifier. For each CoV value of the series of values, a mass spectrometer selects and mass analyzes the at least one precursor ion. An intensity is produced for each CoV value of the series of values. An intensity versus CoV value peak is calculated from the intensities measured. A representative CoV value is calculated for the peak. The difference between the representative CoV value and known CoV values that represent an uncontaminated curtain plate is calculated. If the difference is greater than or equal to a predetermined threshold value, the curtain plate is determined to be contaminated.

公开(公告)号：US11408853B2

公开(公告)日：2022-08-09

申请号：US16962768

申请日：2019-01-08

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Yves Le Blanc ,  Brendon Seale

IPC: H01J49/00 ,  G01N27/62 ,  G01N27/624 ,  H01J49/40 ,  H01J49/42

Abstract: In DM-SWATH a plurality of CoVs and a precursor ion mass range are received. A processor performs an iterative series of steps for each CoV of the plurality of CoVs. For each CoV of the plurality of CoVs, the CoV is applied to the DMS device to select a group of precursor ions. A mass filter is instructed to select precursor ions of the group that are within the precursor ion mass range, producing a subgroup of precursor ions. A fragmentation device is instructed to fragment the subgroup of precursor ions, producing a group of product ions. A mass analyzer is instructed to measure the intensity and m/z of the group of product ions, producing a product ion spectrum for each CoV of the plurality of CoVs. DM-SWATH is further used to validate if a known compound is in a sample.

公开(公告)号：US11761926B2

公开(公告)日：2023-09-19

申请号：US17814258

申请日：2022-07-22

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Yves Le Blanc ,  Brendon Seale

IPC: G01N27/624 ,  H01J49/00 ,  H01J49/40 ,  H01J49/42

CPC classification number: G01N27/624 ,  H01J49/0031 ,  H01J49/0045 ,  H01J49/40 ,  H01J49/4215

Abstract: In DM-SWATH a plurality of CoVs and a precursor ion mass range are received. A processor performs an iterative series of steps for each CoV of the plurality of CoVs. For each CoV of the plurality of CoVs, the CoV is applied to the DMS device to select a group of precursor ions. A mass filter is instructed to select precursor ions of the group that are within the precursor ion mass range, producing a subgroup of precursor ions. A fragmentation device is instructed to fragment the subgroup of precursor ions, producing a group of product ions. A mass analyzer is instructed to measure the intensity and m/z of the group of product ions, producing a product ion spectrum for each CoV of the plurality of CoVs. DM-SWATH is further used to validate if a known compound is in a sample.

公开(公告)号：US20220357301A1

公开(公告)日：2022-11-10

申请号：US17814258

申请日：2022-07-22

Applicant: DH TECHNOLOGIES DEVELOPMENT PTE. LTD.

Inventor： Yves Le Blanc ,  Brendon Seale

IPC: G01N27/624 ,  H01J49/00 ,  H01J49/40 ,  H01J49/42

Abstract: In DM-SWATH a plurality of CoVs and a precursor ion mass range are received. A processor performs an iterative series of steps for each CoV of the plurality of CoVs. For each CoV of the plurality of CoVs, the CoV is applied to the DMS device to select a group of precursor ions. A mass filter is instructed to select precursor ions of the group that are within the precursor ion mass range, producing a subgroup of precursor ions. A fragmentation device is instructed to fragment the subgroup of precursor ions, producing a group of product ions. A mass analyzer is instructed to measure the intensity and m/z of the group of product ions, producing a product ion spectrum for each CoV of the plurality of CoVs. DM-SWATH is further used to validate if a known compound is in a sample.