公开(公告)号：US20250029823A1

公开(公告)日：2025-01-23

申请号：US18569781

申请日：2022-06-24

Applicant: DH Technologies Development Pte. Ltd.

Inventor： John Lawrence CAMPBELL ,  Bill LOYD ,  Pavel RYUMIN

IPC: H01J49/00 ,  H01J49/42

Abstract: The present disclosure provides methods and systems for performing mass spectrometry in which at least two batches of precursor ions generated via ionization of at least two different portions of a sample are exposed to electron beams at different energies to cause fragmentation of at least a portion of the precursor ions. In some embodiments, the electron energies can be selected such at one of the electron energies, EIEIO fragmentation can occur while at the other electron energy, EIEO fragmentation channel is not available. The mass spectra corresponding to the two energies can then be utilized to generate a resultant mass spectrum in which mass peaks corresponding to ion fragments generated by EIEIO dissociation are more readily identifiable.