公开(公告)号：US20240282560A1

公开(公告)日：2024-08-22

申请号：US18571542

申请日：2022-06-24

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Lyle L. BURTON ,  Nic BLOOMFIELD ,  David Michael COX

IPC: H01J49/00 ,  H01J49/40 ,  H01J49/42

CPC classification number: H01J49/0031 ,  H01J49/0036 ,  H01J49/40 ,  H01J49/4215

Abstract: The technology relates to systems and methods for performing mass spectrometry analysis of a sample. An example method may include receiving, as input via an input device, a target mass-to-charge (m/z) ratio for a fragment ion of interest; setting a target m/z range based on the target m/z ratio; ionizing the sample to generate precursor ions; fragmenting the precursor ions to generate fragment ions having a range of mass-to-charge ratios larger than the target m/z range; accelerating the fragment ions to a detector such that fragment ions inside and outside of the target m/z ratio are detected; summing a count of fragment ions within the target m/z range without storing ion counts for fragment ions outside of the target m/z range; and storing the summed ion count as corresponding with the target mass-to-charge ratio.

公开(公告)号：US20240339311A1

公开(公告)日：2024-10-10

申请号：US18294386

申请日：2022-08-05

Applicant: DH Technologies Development Pte. Ltd.

Inventor： Thomas R. COVEY ,  David Michael COX ,  Michael JARVIS ,  Chang LIU

IPC: H01J49/00 ,  H01J49/16

CPC classification number: H01J49/0031 ,  H01J49/165

Abstract: A method for measuring a concentration of an analyte in a sample includes: sampling, from a first sample, a first one or more droplets for mass analysis, wherein the first sample includes the sample; performing mass analysis on the first one or more droplets to determine a first intensity of an analyte in the first one or more droplets; sampling, from a second sample, a second one or more droplets for mass analysis, wherein the sec-ond sample includes the sample and a first spike of the analyte; performing mass analysis on the second one or more droplets to determine a second intensity of the analyte in the second one or more droplets; fitting a curve to the first intensity and the second intensity; and based on the fitted curve, calculating an analyte concentration for the sample.

公开(公告)号：US20240159716A1

公开(公告)日：2024-05-16

申请号：US18550001

申请日：2022-03-18

Applicant: DH Technologies Development Pte. Ltd.

Inventor： David Michael COX ,  Chang LIU

IPC: G01N30/20 ,  B01D15/14 ,  G01N30/22 ,  G01N30/72

CPC classification number: G01N30/20 ,  B01D15/14 ,  G01N30/22 ,  G01N30/7233 ,  G01N2030/201

Abstract: A method of performing liquid chromatography (LC) with an LC system including an LC column and an analyzer includes delivering a transport liquid to an open port interface (OPI) of a sample receiving circuit, wherein the sample receiving circuit includes a sample transfer chamber. A sample is ejected from a sample holder into the OPI with a non-contact ejector. The transport liquid and the sample are received in the sample transfer chamber. The sample transfer chamber is decoupled from the sample receiving circuit. A solvent is delivered to the analysis circuit. The sample is pushed from the sample transfer chamber with the solvent. The sample and the solvent is passed through the LC column to produce an eluent. The eluent is analyzed with the analyzer.