中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

20 records (took 0.051 seconds)

    Microfluidic platform and method of generating a gradient therein
    1.
    发明申请
    Microfluidic platform and method of generating a gradient therein 失效
    微流控平台及其中产生梯度的方法

    公开(公告)号：US20070253868A1

    公开(公告)日：2007-11-01

    申请号：US11411671

    申请日：2006-04-26

    Applicant: David Beebe ,  Vinay Abhyankar

    Inventor： David Beebe ,  Vinay Abhyankar

    IPC: B01L3/02

    CPC classification number: B01F13/0059 ,  B01F13/0093 ,  B01F15/0404 ,  B01L3/5027

    Abstract: An apparatus and method of using the same are provided for generating a gradient of particles within a microfluidic device. The microfluidic device includes a channel having an input and an output. The channel is filled with a predetermined fluid. Thereafter, particles from a source pass through a porous membrane into the input of the channel. A second membrane is provided adjacent the output of the channel to minimize convection therein. A sink communicates with the output of the channel. The source/sink combination creates a pseudo-steady state in the channel wherein the concentration of particles at a point does not vary dramatically with time.

    Abstract translation: 提供了一种使用其的装置和方法，用于在微流体装置内产生颗粒的梯度。 微流体装置包括具有输入和输出的通道。 通道填充有预定流体。 此后，来自源的颗粒通过多孔膜进入通道的输入。 在通道的输出附近设置第二膜以最小化其中的对流。 接收器与信道的输出通信。 源/汇组合在通道中产生伪稳态，其中点处的粒子浓度随时间而不会显着变化。

    Lid For Functionalized Microfluidic Platform And Method
    2.
    发明申请
    Lid For Functionalized Microfluidic Platform And Method 有权
    用于功能化微流控平台和方法的盖

    公开(公告)号：US20130302842A1

    公开(公告)日：2013-11-14

    申请号：US13467584

    申请日：2012-05-09

    Applicant: Erwin Berthier ,  Peter Cavner ,  David John Guckenberger ,  David Beebe

    Inventor： Erwin Berthier ,  Peter Cavner ,  David John Guckenberger ,  David Beebe

    IPC: C12Q1/02 ,  B01L99/00

    CPC classification number: G01N33/5005 ,  A01N1/0263 ,  A01N1/0268 ,  B01L3/502715 ,  B01L7/50 ,  B01L2200/027 ,  B01L2300/044 ,  B01L2300/047 ,  B01L2300/0672 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0406 ,  B01L2400/0481 ,  B01L2400/0677 ,  B01L2400/0683 ,  B01L2400/0694 ,  B01L2400/086

    Abstract: A microfluidic device and method is provided for handheld diagnostics and assays. A first substance is frozen in a cryopreservation fluid in a first well of a lid. The lid includes a first surface communicating with a first port of the first well and a second surface communicating with a second port of the first well. A porous membrane is affixed to the first surface so as to overlap the first port and a non-porous membrane is affixed to the second surface so as to overlap the second port. The first substance may be dialytically freed from the cryopreservation fluid at a user desired time. Thereafter, the lid may be moved from a first position wherein the lid is spaced from a base to a second position wherein the lid is adjacent the channel in the base such that the first substance communicates with the input of the channel.

    Abstract translation: 提供了用于手持诊断和测定的微流体装置和方法。 将第一物质在盖的第一孔中的冷冻保存液中冷冻。 所述盖包括与所述第一井的第一端口连通的第一表面和与所述第一井的第二端口连通的第二表面。 将多孔膜固定在第一表面上以与第一端口重叠，并且非多孔膜固定到第二表面以与第二端口重叠。 第一物质可以在用户期望的时间透析地从冷冻保存液中除去。 此后，盖可以从第一位置移动，其中盖子与基座间隔开到第二位置，其中盖子与基座中的通道相邻，使得第一物质与通道的输入端相通。

    METHOD FOR ISOLATING WEAKLY INTERACTING MOLECULES FROM A FLUIDIC SAMPLE
    3.
    发明申请
    METHOD FOR ISOLATING WEAKLY INTERACTING MOLECULES FROM A FLUIDIC SAMPLE 有权
    从流体样品中分离弱相互作用分子的方法

    公开(公告)号：US20120178096A1

    公开(公告)日：2012-07-12

    申请号：US12987934

    申请日：2011-01-10

    Applicant: David Beebe ,  Richard Burgess ,  Lindsay Strotman ,  Scott Berry

    Inventor： David Beebe ,  Richard Burgess ,  Lindsay Strotman ,  Scott Berry

    IPC: C12Q1/68 ,  G01N33/53 ,  G01N33/553 ,  G01N33/543

    CPC classification number: G01N33/54326 ,  G01N33/543

    Abstract: Methods of isolating weakly interacting molecules in a fluidic sample using an immiscible phase filtration technique are disclosed. A complex is formed between a solid phase substrate, a molecule immobilized on the solid phase substrate, and at least one target molecule present in the fluidic sample. The complex is transferred into an immiscible phase by applying an external force to the solid phase substrate. The methods eliminate the need for complex and time consuming washing steps.

    Abstract translation: 公开了使用不混溶相过滤技术在流体样品中分离弱相互作用分子的方法。 在固相底物，固相在固相底物上的分子与存在于流体样品中的至少一种靶分子之间形成复合物。 通过向固相基质施加外力将复合物转移到不混溶相中。 该方法消除了对复杂和耗时的洗涤步骤的需要。

    Micro device and method for high resolusion delivery and monitoring of stimuli to a biological object, in vitro
    6.
    发明申请
    Micro device and method for high resolusion delivery and monitoring of stimuli to a biological object, in vitro 有权
    用于高分辨率递送和监测生物对象的刺激的微装置和方法

    公开(公告)号：US20050282267A1

    公开(公告)日：2005-12-22

    申请号：US10872647

    申请日：2004-06-21

    Applicant: Justin Williams ,  David Beebe ,  Stephen Johnson

    Inventor： Justin Williams ,  David Beebe ,  Stephen Johnson

    IPC: C12M1/34 ,  C12M1/42 ,  G01F1/64

    CPC classification number: C12M41/46 ,  C12M35/08

    Abstract: A micro device and method are provided for examining and testing a slice of a biological object, such as brain tissue. The micro device includes a body defining a chamber and a channel in communication with the chamber. A stimulation fluid flows axially along a flow path in the channel and engages a user selectable region of the slice. An array of electrodes in the chamber engages the slice and allows for the multi-channel electrical recording and stimulation of the slice at each of the electrode sites.

    Abstract translation: 提供了用于检查和测试诸如脑组织的生物体的切片的微装置和方法。 微型装置包括限定腔室的主体和与腔室连通的通道。 刺激流体沿着通道中的流动路径轴向流动并且接合切片的用户可选择区域。 腔室中的电极阵列接合切片并且允许在每个电极位置处的多通道电记录和切片的刺激。

    Active compressor vapor compression cycle integrated heat transfer device
    7.
    发明授权
    Active compressor vapor compression cycle integrated heat transfer device 有权
    主动压缩机蒸汽压缩循环集成传热装置

    公开(公告)号：US6148635A

    公开(公告)日：2000-11-21

    申请号：US174813

    申请日：1998-10-19

    Applicant: David Beebe ,  Clark Bullard ,  Michael Philpott ,  Mark Shannon

    Inventor： David Beebe ,  Clark Bullard ,  Michael Philpott ,  Mark Shannon

    IPC: F04B43/02 ,  F04B43/04 ,  F04B43/06 ,  F04B43/12 ,  F25B1/00 ,  F25B1/02 ,  F25B39/00 ,  F25B41/06 ,  F25B49/02 ,  F28D9/00 ,  F28B1/00

    CPC classification number: F28F3/048 ,  F04B43/043 ,  F25B1/02 ,  F25B39/00 ,  F28D9/00 ,  F25B2400/15 ,  F28D2021/0068 ,  F28F2260/02

    Abstract: A compact active vapor compression cycle heat transfer device. The device of the invention includes a flexible diaphragm serving as the compressive member in a layered compressor. The compressor is stimulated by capacitive electrical action and drives the relatively small refrigerant charge for the device through a closed loop defined by the compressor, an evaporator and a condenser. The evaporator and condenser include microchannel heat exchange elements to respectively draw heat from an atmosphere on a cool side of the device and expel heat into an atmosphere on a hot side of the device. The overall structure and size of the device is similar to microelectronic packages, and it may be combined to operate with similar devices in useful arrays.

    Abstract translation: 一种紧凑的主动蒸气压缩循环传热装置。 本发明的装置包括在分层压缩机中用作压缩构件的柔性隔膜。 压缩机由电容性电动作用刺激，并通过由压缩机，蒸发器和冷凝器限定的闭合回路来驱动装置的相对较小的制冷剂装料。 蒸发器和冷凝器包括微通道热交换元件，以分别从装置的冷却侧的气氛中吸收热量，并将热量排放到装置的热侧上的气氛中。 器件的总体结构和尺寸与微电子封装类似，并且可以将其组合以与有用阵列中的类似器件一起工作。

    Method for isolating weakly interacting molecules from a fluidic sample
    8.
    发明授权
    Method for isolating weakly interacting molecules from a fluidic sample 有权
    从流体样品中分离弱相互作用的分子的方法

    公开(公告)号：US08993243B2

    公开(公告)日：2015-03-31

    申请号：US12987934

    申请日：2011-01-10

    Applicant: David Beebe ,  Richard Burgess ,  Lindsay Strotman ,  Scott Berry

    Inventor： David Beebe ,  Richard Burgess ,  Lindsay Strotman ,  Scott Berry

    IPC: C12Q1/68 ,  G01N33/543

    CPC classification number: G01N33/54326 ,  G01N33/543

    Abstract: Methods of isolating weakly interacting molecules in a fluidic sample using an immiscible phase filtration technique are disclosed. A complex is formed between a solid phase substrate, a molecule immobilized on the solid phase substrate, and at least one target molecule present in the fluidic sample. The complex is transferred into an immiscible phase by applying an external force to the solid phase substrate. The methods eliminate the need for complex and time consuming washing steps.

    Abstract translation: 公开了使用不混溶相过滤技术在流体样品中分离弱相互作用分子的方法。 在固相底物，固相在固相底物上的分子与存在于流体样品中的至少一种靶分子之间形成复合物。 通过向固相基质施加外力将复合物转移到不混溶相中。 该方法消除了对复杂和耗时的洗涤步骤的需要。

    Device and method for alerting a runner when a new pair of running shoes is needed
    9.
    发明申请
    Device and method for alerting a runner when a new pair of running shoes is needed 有权
    当需要新的一双跑步鞋时，提醒跑步者的装置和方法

    公开(公告)号：US20060152377A1

    公开(公告)日：2006-07-13

    申请号：US11033370

    申请日：2005-01-11

    Applicant: David Beebe ,  Brian Schwartz ,  Steven Pauls ,  Timothy Rand ,  Brant Kochsiek

    Inventor： David Beebe ,  Brian Schwartz ,  Steven Pauls ,  Timothy Rand ,  Brant Kochsiek

    IPC: G08B21/00 ,  G01N3/56 ,  G01M19/00 ,  G08B19/00

    CPC classification number: A43B3/001 ,  A43B3/0005 ,  A43B5/00 ,  A43B7/00 ,  G01N3/56

    Abstract: A device and method are provided for determining the wear of a sole of a shoe. The device includes first and second sensors receivable in the sole of the shoe. The sensors are axially spaced and generate signals in response to corresponding impact forces acting thereon. A control circuit is connectable to the first and second sensors. The control circuit compares the difference between the first and second signals to a threshold and generates an alert signal in response to the difference between the first and second signal meeting the threshold.

    Abstract translation: 提供了一种用于确定鞋底的磨损的装置和方法。 该装置包括可容纳在鞋底中的第一和第二传感器。 传感器轴向间隔开并响应于作用于其上的相应冲击力产生信号。 控制电路可连接到第一和第二传感器。 控制电路将第一和第二信号之间的差异与阈值进行比较，并且响应于满足阈值的第一和第二信号之间的差异而产生报警信号。

Patent Agency Ranking