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公开(公告)号：US09283559B2
公开(公告)日：2016-03-15
申请号：US13467584
申请日：2012-05-09
Applicant: Erwin Berthier , Peter Cavnar , David John Guckenberger , David Beebe
Inventor： Erwin Berthier , Peter Cavnar , David John Guckenberger , David Beebe
CPC classification number: G01N33/5005 , A01N1/0263 , A01N1/0268 , B01L3/502715 , B01L7/50 , B01L2200/027 , B01L2300/044 , B01L2300/047 , B01L2300/0672 , B01L2300/0816 , B01L2300/0887 , B01L2400/0406 , B01L2400/0481 , B01L2400/0677 , B01L2400/0683 , B01L2400/0694 , B01L2400/086
Abstract: A microfluidic device and method is provided for handheld diagnostics and assays. A first substance is frozen in a cryopreservation fluid in a first well of a lid. The lid includes a first surface communicating with a first port of the first well and a second surface communicating with a second port of the first well. A porous membrane is affixed to the first surface so as to overlap the first port and a non-porous membrane is affixed to the second surface so as to overlap the second port. The first substance may be dialytically freed from the cryopreservation fluid at a user desired time. Thereafter, the lid may be moved from a first position wherein the lid is spaced from a base to a second position wherein the lid is adjacent the channel in the base such that the first substance communicates with the input of the channel.
Abstract translation: 提供了用于手持诊断和测定的微流体装置和方法。 将第一物质在盖的第一孔中的冷冻保存液中冷冻。 所述盖包括与所述第一井的第一端口连通的第一表面和与所述第一井的第二端口连通的第二表面。 将多孔膜固定在第一表面上以与第一端口重叠，并且非多孔膜固定到第二表面以与第二端口重叠。 第一物质可以在用户期望的时间透析地从冷冻保存液中除去。 此后，盖可以从第一位置移动，其中盖子与基座间隔开到第二位置，其中盖子与基座中的通道相邻，使得第一物质与通道的输入端相通。
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公开(公告)号：US20130158240A1
公开(公告)日：2013-06-20
申请号：US13326832
申请日：2011-12-15
Applicant: David Beebe , Lindsay Strolman , Scott M. Berry
Inventor： David Beebe , Lindsay Strolman , Scott M. Berry
Abstract: A method is provided for facilitating extraction of a fraction from a biological sample. The biological sample includes non-desired material and a fraction-bound solid phase substrate. The method includes the steps of capturing the fraction-bound solid phase substrate and bringing an isolation buffer and the fraction-bound solid phase substrate into contact to purify the captured fraction-bound solid phase substrate.
Abstract translation: 提供了一种便于从生物样品中萃取级分的方法。 生物样品包括非期望的材料和分数结合的固相底物。 该方法包括以下步骤：捕获部分结合的固相底物并使分离缓冲液和分馏结合的固相底物接触以净化捕获的部分结合的固相底物。
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公开(公告)号：US20070253868A1
公开(公告)日：2007-11-01
申请号：US11411671
申请日：2006-04-26
Applicant: David Beebe , Vinay Abhyankar
Inventor： David Beebe , Vinay Abhyankar
IPC: B01L3/02
CPC classification number: B01F13/0059 , B01F13/0093 , B01F15/0404 , B01L3/5027
Abstract: An apparatus and method of using the same are provided for generating a gradient of particles within a microfluidic device. The microfluidic device includes a channel having an input and an output. The channel is filled with a predetermined fluid. Thereafter, particles from a source pass through a porous membrane into the input of the channel. A second membrane is provided adjacent the output of the channel to minimize convection therein. A sink communicates with the output of the channel. The source/sink combination creates a pseudo-steady state in the channel wherein the concentration of particles at a point does not vary dramatically with time.
Abstract translation: 提供了一种使用其的装置和方法，用于在微流体装置内产生颗粒的梯度。 微流体装置包括具有输入和输出的通道。 通道填充有预定流体。 此后，来自源的颗粒通过多孔膜进入通道的输入。 在通道的输出附近设置第二膜以最小化其中的对流。 接收器与信道的输出通信。 源/汇组合在通道中产生伪稳态，其中点处的粒子浓度随时间而不会显着变化。
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公开(公告)号：US20060110722A1
公开(公告)日：2006-05-25
申请号：US10997259
申请日：2004-11-24
Applicant: David Beebe , Jaisree Moorthy , Richard Burgess
Inventor： David Beebe , Jaisree Moorthy , Richard Burgess
CPC classification number: B01L3/5027 , B01L2200/0668 , B01L2300/0822 , B01L2300/0877
Abstract: A platform and method for mimicking the environment within a cell is provided. The platform includes a microfluidic device defining a chamber. At least one hydrogel post is positioned within the chamber of the microfluidic device. Each hydrogel post defines a corresponding pore for receiving a first molecule therein. Second molecules are introduced into the pores of the hydrogel posts and the interactions between the first and second molecules are observed.
Abstract translation: 提供了一种用于模拟单元内的环境的平台和方法。 平台包括限定腔室的微流体装置。 至少一个水凝胶柱位于微流体装置的腔室内。 每个水凝胶柱限定了用于在其中接收第一分子的相应的孔。 将第二分子引入水凝胶柱的孔中，观察第一和第二分子之间的相互作用。
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公开(公告)号：US20050244512A1
公开(公告)日：2005-11-03
申请号：US10836569
申请日：2004-05-01
Applicant: Nancy Holekamp , David Beebe , Ying-Bo Shui , Steven Bassnett , Richard McNulty
Inventor： Nancy Holekamp , David Beebe , Ying-Bo Shui , Steven Bassnett , Richard McNulty
CPC classification number: A61K33/14 , A61K38/063 , A61M5/44 , A61K2300/00
Abstract: A method for preparing and infusing an ophthalmic fluid into an eye includes de-oxygenating the fluid and infusing the fluid into the eye. In another aspect, the fluid is warmed such that it enters the eye within a temperature range of about 30 degrees C. to about 37 degrees C.
Abstract translation: 用于将眼液制备和注入眼睛的方法包括使流体脱氧并将流体注入眼睛。 另一方面，流体被加热使得其在大约30摄氏度到大约37摄氏度的温度范围内进入眼睛。
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Patent Agency Ranking
公开(公告)号：US20050038379A1
公开(公告)日：2005-02-17
申请号：US10762664
申请日：2004-01-22
Applicant: David Beebe , Michael MacDonald , David Eddington , Glennys Mensing
Inventor： David Beebe , Michael MacDonald , David Eddington , Glennys Mensing
CPC classification number: A61M5/141 , A61M5/14248 , A61M5/14586 , A61M5/16881 , A61M2005/1726
Abstract: A microfluidic device is provided for delivering a drug to an individual. The microfluidic device includes a body that defines a reservoir for receiving the drug therein. A valve interconnects the reservoir to an output needle that is insertable into the skin of an individual. A pressure source urges the drug from the reservoir toward the needle. The valve is movable between a closed position preventing the flow of the drug from the reservoir to the output needle and an open position allowing for the flow of the drug from the reservoir to the output needle in response to a predetermined condition in the physiological fluids of the individual.
Abstract translation: 提供了用于将药物递送给个体的微流体装置。 微流体装置包括限定用于在其中接收药物的储存器的主体。 阀将储存器互连到可插入个人皮肤的输出针。 压力源将药物从储存器推向针。 所述阀可在关闭位置之间移动，所述关闭位置防止药物从所述贮存器流到所述输出针，以及打开位置，以允许所述药物从所述储存器流动到所述输出针，以响应于所述生理流体中的预定条件 个人
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公开(公告)号：US06248668B1
公开(公告)日：2001-06-19
申请号：US09483153
申请日：2000-01-14
Applicant: David Beebe , Hyuk-Jeen Suh , Jeffrey S. Moore , Pamidighantam Bharathi
Inventor： David Beebe , Hyuk-Jeen Suh , Jeffrey S. Moore , Pamidighantam Bharathi
IPC: H01L21302
CPC classification number: B81B3/0005 , B81C1/00936 , B81C2201/0108
Abstract: A micro-scale gap fabrication process using a dry releasable dendritic material sacrificial layer. The fabrication process produces micro-scale gaps, such as those required between a suspended microstructure and an opposing surface in MEMS. The dendritic sacrificial layer is releasable by heating the dendritic material past its decomposition point after forming the microstructure. The sacrificial layer may be applied to a wafer, for example, by spin coating a solution including the dissolved dendritic material. The sacrificial layer, after being formed, may be patterned and prepared for accepting structural material for the microstructure. After a desired microstructure or microstructures are formed around the sacrificial layer, the layer is dry releasable by heating.
Abstract translation: 使用干可剥离树枝状材料牺牲层的微尺度间隙制造工艺。 制造过程产生微尺度间隙，例如在MEMS中的悬浮微结构和相对表面之间所需的间隙。 树枝状牺牲层通过在形成微观结构之后通过加热树枝状材料经过其分解点来释放。 牺牲层可以施加到晶片上，例如通过旋涂包括溶解的树枝状材料的溶液。 形成后的牺牲层可以被图案化并制备用于接受微结构的结构材料。 在围绕牺牲层形成期望的微结构或微结构之后，通过加热可以释放该层。
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公开(公告)号：US20130302842A1
公开(公告)日：2013-11-14
申请号：US13467584
申请日：2012-05-09
Applicant: Erwin Berthier , Peter Cavner , David John Guckenberger , David Beebe
Inventor： Erwin Berthier , Peter Cavner , David John Guckenberger , David Beebe
CPC classification number: G01N33/5005 , A01N1/0263 , A01N1/0268 , B01L3/502715 , B01L7/50 , B01L2200/027 , B01L2300/044 , B01L2300/047 , B01L2300/0672 , B01L2300/0816 , B01L2300/0887 , B01L2400/0406 , B01L2400/0481 , B01L2400/0677 , B01L2400/0683 , B01L2400/0694 , B01L2400/086
Abstract: A microfluidic device and method is provided for handheld diagnostics and assays. A first substance is frozen in a cryopreservation fluid in a first well of a lid. The lid includes a first surface communicating with a first port of the first well and a second surface communicating with a second port of the first well. A porous membrane is affixed to the first surface so as to overlap the first port and a non-porous membrane is affixed to the second surface so as to overlap the second port. The first substance may be dialytically freed from the cryopreservation fluid at a user desired time. Thereafter, the lid may be moved from a first position wherein the lid is spaced from a base to a second position wherein the lid is adjacent the channel in the base such that the first substance communicates with the input of the channel.
Abstract translation: 提供了用于手持诊断和测定的微流体装置和方法。 将第一物质在盖的第一孔中的冷冻保存液中冷冻。 所述盖包括与所述第一井的第一端口连通的第一表面和与所述第一井的第二端口连通的第二表面。 将多孔膜固定在第一表面上以与第一端口重叠，并且非多孔膜固定到第二表面以与第二端口重叠。 第一物质可以在用户期望的时间透析地从冷冻保存液中除去。 此后，盖可以从第一位置移动，其中盖子与基座间隔开到第二位置，其中盖子与基座中的通道相邻，使得第一物质与通道的输入端相通。
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9.发明申请公开(公告)号：US20120178096A1
公开(公告)日：2012-07-12
申请号：US12987934
申请日：2011-01-10
Applicant: David Beebe , Richard Burgess , Lindsay Strotman , Scott Berry
Inventor： David Beebe , Richard Burgess , Lindsay Strotman , Scott Berry
IPC: C12Q1/68 , G01N33/53 , G01N33/553 , G01N33/543
CPC classification number: G01N33/54326 , G01N33/543
Abstract: Methods of isolating weakly interacting molecules in a fluidic sample using an immiscible phase filtration technique are disclosed. A complex is formed between a solid phase substrate, a molecule immobilized on the solid phase substrate, and at least one target molecule present in the fluidic sample. The complex is transferred into an immiscible phase by applying an external force to the solid phase substrate. The methods eliminate the need for complex and time consuming washing steps.
Abstract translation: 公开了使用不混溶相过滤技术在流体样品中分离弱相互作用分子的方法。 在固相底物，固相在固相底物上的分子与存在于流体样品中的至少一种靶分子之间形成复合物。 通过向固相基质施加外力将复合物转移到不混溶相中。 该方法消除了对复杂和耗时的洗涤步骤的需要。
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公开(公告)号：US20070231832A1
公开(公告)日：2007-10-04
申请号：US11555103
申请日：2006-10-31
Applicant: Nicholas Abbott , Joon-Seo Park , Sarah Teren , David Beebe , Eric Johnson
Inventor： Nicholas Abbott , Joon-Seo Park , Sarah Teren , David Beebe , Eric Johnson
IPC: G01N33/573 , C09K19/00 , G01N31/22 , G01N33/53 , G01N33/566
CPC classification number: C12Q1/37 , B82Y30/00 , G01N33/54373
Abstract: The present invention provides liquid crystal-based devices and methods for bioagent detection. In certain aspects, the present invention is directed to devices and methods utilizing liquid crystals and membranes containing polymerized targets that can report the presence of bioagents including, but not limited to, enzymes, antibodies, and toxins.
Abstract translation: 本发明提供了基于液晶的装置和用于生物鉴定检测的方法。 在某些方面，本发明涉及利用液晶和含有聚合靶的膜的装置和方法，所述聚合靶可以报告生物制剂的存在，包括但不限于酶，抗体和毒素。
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