公开(公告)号：US20190150729A1

公开(公告)日：2019-05-23

申请号：US16308901

申请日：2017-06-15

Applicant: David Huang ,  Gangjun Liu ,  Yali Jia

Inventor： David Huang ,  Gangjun Liu ,  Yali Jia

IPC: A61B3/10 ,  A61B3/00 ,  A61B3/12 ,  A61B5/00 ,  A61B5/11 ,  A61B5/02

Abstract: Disclosed are systems and methods for generating wide-field optical coherence tomography angiography (OCTA) images. In embodiments, multiple OCTA scans of a sample are automatically acquired at overlapping locations. The systems and methods include functionality to adaptively control the scanning procedure such that eye blink and eye motion events are detected in real time and accounted for during 3D scan acquisition. Also disclosed are methods for detecting and correcting motion-related artifacts in OCTA datasets which allow for the longer scan times over larger fields of view required for wide-field imaging. These methods may include division of en face angiogram images into a set of motion-free parallel strips, and application of gross and fine registration methods to align overlapping strips into a motion-corrected composite image. A series of overlapping motion-corrected composite images may be combined into a larger montage to enable wide-field OCTA imaging using multiple OCTA scans.

公开(公告)号：US20160317020A1

公开(公告)日：2016-11-03

申请号：US15141626

申请日：2016-04-28

Applicant: Gangjun Liu ,  David Huang ,  Yali Jia

Inventor： Gangjun Liu ,  David Huang ,  Yali Jia

IPC: A61B3/00 ,  A61B3/12 ,  G01B9/02

CPC classification number: A61B3/0025 ,  A61B3/102 ,  A61B3/1233 ,  G01B9/02004 ,  G01B9/02045 ,  G01B9/02076 ,  G01B9/02091

Abstract: Disclosed are methods of imaging vascular flow using optical coherence tomography. The methods involve calculating an OCT phase difference and an OCT phase gradient from interference fringes acquired from B-scans. The methods can be implemented in a split-spectrum embodiment to enhance the signal to noise ratio of vascular flow images. The methods also obviate the need for correction of bulk motion and laser trigger jitter-induced phase artifacts.

Abstract translation: 公开了使用光学相干断层扫描成像血管流动的方法。 该方法涉及从B扫描获得的干涉条纹计算OCT相位差和OCT相位梯度。 该方法可以在分裂实施例中实现，以增强血管图像的信噪比。 这些方法也避免了校正体积运动和激光触发抖动引起的相位伪影的需要。

公开(公告)号：US10327631B2

公开(公告)日：2019-06-25

申请号：US14996134

申请日：2016-01-14

Applicant: David Huang ,  Gangjun Liu

Inventor： David Huang ,  Gangjun Liu

IPC: G01B9/02 ,  A61B3/10 ,  A61B3/00 ,  A61B3/12

Abstract: Disclosed herein are methods and systems for aligning swept-source optical coherence tomography (SS-OCT) spectral interferograms to a reference spectral interferogram based on signal information (e.g., amplitude or phase) at a fixed-pattern noise location to reduce residual fixed-pattern noise and improve the phase stability of SS-OCT systems.

公开(公告)号：US20160206195A1

公开(公告)日：2016-07-21

申请号：US14996134

申请日：2016-01-14

Applicant: David Huang ,  Gangjun Liu

Inventor： David Huang ,  Gangjun Liu

IPC: A61B3/10 ,  A61B3/12 ,  A61B3/00 ,  G01B9/02

CPC classification number: A61B3/102 ,  A61B3/0025 ,  A61B3/1233 ,  G01B9/02004 ,  G01B9/0207 ,  G01B9/02091

Abstract: Disclosed herein are methods and systems for aligning swept-source optical coherence tomography (SS-OCT) spectral interferograms to a reference spectral interferogram based on signal information (e.g., amplitude or phase) at a fixed-pattern noise location to reduce residual fixed-pattern noise and improve the phase stability of SS-OCT systems.

Abstract translation: 本文公开了用于将扫频光学相干断层扫描（SS-OCT）光谱干涉图基于固定模式噪声位置处的信号信息（例如，幅度或相位）对准参考光谱干涉图进行对准以减少残余固定模式的方法和系统 提高SS-OCT系统的相位稳定性。

公开(公告)号：US20180344147A1

公开(公告)日：2018-12-06

申请号：US16000824

申请日：2018-06-05

Applicant: David Huang ,  Yali Jia

Inventor： David Huang ,  Yali Jia

IPC: A61B3/00 ,  A61B3/12 ,  A61B3/14 ,  A61B3/10

CPC classification number: A61B3/0025 ,  A61B3/0041 ,  A61B3/102 ,  A61B3/1233 ,  A61B3/1241 ,  A61B3/14

Abstract: Methods of applying OCT angiography are disclosed. In particular, methods of detecting, visualizing and measuring the extent of retinal neovascularization are disclosed. Further disclosed are methods measuring retinal nonperfusion area and choriocapillaris defect area.

公开(公告)号：US09918630B2

公开(公告)日：2018-03-20

申请号：US15253597

申请日：2016-08-31

Applicant: Ou Tan ,  David Huang

Inventor： Ou Tan ,  David Huang

IPC: A61B3/12 ,  A61B3/00 ,  A61B3/10

CPC classification number: A61B3/1225 ,  A61B3/0025 ,  A61B3/102 ,  G06T7/136 ,  G06T2207/30041

Abstract: A method for detecting glaucoma in a subject based on spatial frequency analysis of the inner limiting membrane (ILM) as obtained from optical coherence tomography (OCT) image data is disclosed. Based on the spatial frequency content of the analyzed ILM profile, a quantity called the Retinal surface contour variability (RSCV) is calculated and the presence or absence of a glaucoma condition is determined based on the RSCV magnitude.

公开(公告)号：US09621334B2

公开(公告)日：2017-04-11

申请号：US12212418

申请日：2008-09-17

Applicant: David Huang ,  Wei-Chih Chang ,  Tsung-Pao Kuan

Inventor： David Huang ,  Wei-Chih Chang ,  Tsung-Pao Kuan

IPC: H03D1/00 ,  H04J11/00 ,  H04L7/02 ,  H04B7/04 ,  H04L7/033

CPC classification number: H04L7/02 ,  H04B7/04 ,  H04L7/033

Abstract: A data transmission method for a data transmission system including a first device and a second device is disclosed. The method comprises the steps of transmitting a clock signal to synchronize the first device and the second device; transmitting a mode signal from the first device to the second device, wherein the mode signal indicates a transmission mode between the first device and the second device; and transmitting a serial data between the first device and the second device based on the clock signal, wherein the length of the serial data is determined based on the transmission mode.

公开(公告)号：US20170055829A1

公开(公告)日：2017-03-02

申请号：US15253597

申请日：2016-08-31

Applicant: Ou Tan ,  David Huang

Inventor： Ou Tan ,  David Huang

IPC: A61B3/12 ,  A61B3/10 ,  A61B3/00

CPC classification number: A61B3/1225 ,  A61B3/0025 ,  A61B3/102 ,  G06T7/136 ,  G06T2207/30041

Abstract: A method for detecting glaucoma in a subject based on spatial frequency analysis of the inner limiting membrane (ILM) as obtained from optical coherence tomography (OCT) image data is disclosed. Based on the spatial frequency content of the analyzed ILM profile, a quantity called the Retinal surface contour variability (RSCV) is calculated and the presence or absence of a glaucoma condition is determined based on the RSCV magnitude.

Abstract translation: 公开了一种基于从光学相干断层摄影（OCT）图像数据获得的内部限制膜（ILM）的空间频率分析来检测受试者中的青光眼的方法。 基于所分析的ILM谱的空间频率含量，计算称为视网膜表面轮廓变异性（RSCV）的量，并且基于RSCV幅度确定青光眼状况的存在或不存在。

公开(公告)号：US20160287071A1

公开(公告)日：2016-10-06

申请号：US15089803

申请日：2016-04-04

Applicant: Ou Tan ,  David Huang

Inventor： Ou Tan ,  David Huang

IPC: A61B3/12 ,  G06T5/00 ,  G06T7/00 ,  A61B3/10 ,  A61B3/00

CPC classification number: A61B3/1233 ,  A61B3/0025 ,  A61B3/102 ,  A61B3/1241 ,  A61B5/7203 ,  A61B6/5258 ,  G06K9/0061 ,  G06K9/52 ,  G06K2209/05 ,  G06T7/0012 ,  G06T2207/10101 ,  G06T2207/30041 ,  G06T2207/30104

Abstract: Methods of performing en face Doppler total retinal blood flow measurement are disclosed. The methods involve obtaining a set of structural OCT scans; calculating a noise-reduced set of Doppler phase shift images by dividing the full spectrum OCT fringe data into a set of narrower filtered frequency bands for phase shift calculation; removing bulk motion along a depth direction; detecting retinal vessels in the set of images; applying a phase unwrapping algorithm to the images; classifying the vessels as veins and arteries; and calculating total retinal blood flow based on that classification.

Abstract translation: 公开了执行面部多普勒总视网膜血流量测量的方法。 该方法涉及获得一组结构OCT扫描; 通过将全谱OCT边缘数据划分成一组较窄的滤波频带以进行相移计算，来计算多普勒相移图像的噪声降低集合; 沿深度方向去除大量运动; 检测该组图像中的视网膜血管; 对图像应用相位解包算法; 将血管分类为静脉和动脉; 并根据该分类计算总视网膜血流量。

公开(公告)号：US20140063806A1

公开(公告)日：2014-03-06

申请号：US13596133

申请日：2012-08-28

Applicant: David Huang

Inventor： David Huang

IPC: F21V29/00

CPC classification number: F21V29/507 ,  F21K9/00 ,  F21V19/0055 ,  F21V23/023 ,  F21V29/83 ,  F21Y2103/33 ,  F21Y2115/10

Abstract: A heat-dissipating structure for LED lamp has a lamp cover, and a power conversion device and a ceramic substrate mounted inside the lamp cover. The lamp cover has multiple heat-dissipating holes and multiple mounting ears. Each mounting ear is formed on an edge of one of the heat-dissipating holes and is bent inwardly with the heat-dissipating hole uncovered. The ceramic substrate is mounted on the mounting ears. The ceramic substrate has multiple LEDs mounted thereon, absorbs heat generated when the LEDs emit light and conducts the heat to the lamp cover through the mounting ears. The heat generated when the LEDs are lit and the power conversion converts a mains power is transferred to a heat convection space between the ceramic substrate and the lamp cover, and is further dissipated to an ambient environment, thereby achieving fast heat dissipation and a light LED lamp without additional heat sink thereon.

Abstract translation: 用于LED灯的散热结构具有灯罩，安装在灯罩内部的电力转换装置和陶瓷基板。 灯罩有多个散热孔和多个安装耳。 每个安装耳形成在一个散热孔的边缘上，并且在散热孔未被覆盖的同时向内弯曲。 陶瓷基板安装在安装耳上。 陶瓷基板上安装有多个LED，吸收当LED发光时产生的热量，并通过安装耳将热量传导到灯罩。 当LED点亮并且功率转换转换为主电源时产生的热量被传递到陶瓷基板和灯罩之间的热对流空间，并且进一步消散到周围环境，从而实现快速散热，并且将LED 灯，其上没有额外的散热器。