公开(公告)号：US20240141341A1

公开(公告)日：2024-05-02

申请号：US18279996

申请日：2022-03-01

Applicant: Duke University

Inventor： Charles A. Gersbach ,  Alejandro Barrera ,  Tyler S. Klann ,  Maria ter Weele ,  Gregory E. Crawford ,  Timothy E. Reddy

IPC: C12N15/113 ,  A61K38/00 ,  C12N9/22

CPC classification number: C12N15/113 ,  C12N9/22 ,  A61K38/00 ,  C12N2310/20 ,  C12N2320/12

Abstract: Disclosed herein am compositions and methods for targeting a novel regulatory element of agene. The compositions may be used in methods of modifying growth of a cell, decreasing cell fitness, increasing cell fitness, and/or treating cancer such as leukemia.

公开(公告)号：US20240058425A1

公开(公告)日：2024-02-22

申请号：US18180718

申请日：2023-03-08

Applicant: Duke University

Inventor： Charles A. Gersbach ,  Alejandro Barrera ,  Tyler S. Klann ,  Maria ter Weele ,  Gregory E. Crawford ,  Timothy E. Reddy

IPC: A61K38/46 ,  C12N15/11 ,  C12N9/22 ,  C12N15/90 ,  C12N15/86 ,  C12N15/10 ,  C12N5/09 ,  A61K31/7088 ,  A61P35/02

CPC classification number: A61K38/465 ,  C12N15/11 ,  C12N9/22 ,  C12N15/907 ,  C12N15/86 ,  C12N15/1082 ,  C12N5/0694 ,  A61K31/7088 ,  A61P35/02 ,  C12N2310/20 ,  C12N2800/80 ,  C12N2740/15043

Abstract: Disclosed herein are compositions and methods for targeting a novel regulatory element of a gene. The compositions may be used in methods of modifying growth of a cell, decreasing cell fitness, increasing cell fitness, and/or treating cancer such as leukemia.