公开(公告)号：US20170304488A1

公开(公告)日：2017-10-26

申请号：US15526259

申请日：2015-11-11

Applicant: Duke University

Inventor： Howard Levinson ,  Kam W. Leong ,  Elizabeth R. Lorden ,  Kyle J. Miller

IPC: A61L27/18 ,  A61L27/54 ,  A61L27/34 ,  C08L67/04 ,  A61L27/58 ,  A61L27/00

CPC classification number: A61L27/18 ,  A61L27/00 ,  A61L27/34 ,  A61L27/54 ,  A61L27/58 ,  C08L67/04

Abstract: The present disclosure provides methods of preventing and/or reducing scar contraction by utilizing an electrospun biocompatible scaffold.

公开(公告)号：US20190160198A1

公开(公告)日：2019-05-30

申请号：US16318855

申请日：2017-07-18

Applicant: Duke University

Inventor： Howard Levinson ,  Elizabeth R. Lorden ,  David A. Brown

IPC: A61L15/32 ,  A61L27/58 ,  A61L27/56 ,  A61L27/54 ,  A61L27/34 ,  A61L27/18 ,  A61L26/00

Abstract: Disclosed herein are wound healing products and methods of making and using the same. The wound healing product comprises a porous scaffold and collagen bound thereon. The scaffold may comprise a poly(L-lactide-co-ε-caprolactone) polymer (PLCL) substrate. In some embodiments, the PLCL substrate comprises a mixture of poly(lactic acid) (PLA) and poly(ε-caprolactone) (PLC) and wherein the PLA and PLC are present in a ratio of about 60:40 to about 40:60. In some embodiments, the collagen is collagen I or collagen III. The scaffold may also have a thickness of at least 0.2 mm.

公开(公告)号：US20160081858A1

公开(公告)日：2016-03-24

申请号：US14785264

申请日：2014-04-16

Applicant: DUKE UNIVERSITY

Inventor： Howard Levinson ,  Kam W. Leong ,  Elizabeth R. Lorden

IPC: A61F13/00 ,  A61F2/12

CPC classification number: A61F13/00063 ,  A61F2/12 ,  A61F13/00017 ,  A61F13/00051 ,  A61F2013/00357

Abstract: The present disclosure provides methods of preventing and/or reducing scar contracture and methods of promoting wound healing by utilizing an electrospun biocompatible scaffold.

Abstract translation: 本公开提供了通过利用电纺生物相容性支架来预防和/或减少瘢痕挛缩的方法和促进伤口愈合的方法。