公开(公告)号：US12031912B2

公开(公告)日：2024-07-09

申请号：US17607761

申请日：2020-05-02

Applicant: Duke University

Inventor： Jason Liu ,  Ashutosh Chilkoti

IPC: G01N21/64

CPC classification number: G01N21/6452 ,  G01N21/6402 ,  G01N21/6428 ,  G01N21/6456 ,  G01N2021/6439 ,  G01N2201/022 ,  G01N2201/06113 ,  G01N2201/0642

Abstract: A microarray chip imaging detector comprises a housing configured to receive a microarray chip. The detector includes a laser assembly supported by the housing and oriented at an angle relative to the microarray chip, the laser assembly configured to transmit an excitation beam along a first axis to samples on the microarray chip. The detector also includes a camera supported by the housing and positioned along a second axis, the camera configured to receive fluorescent light emitted from fluorophores in the samples on the microarray chip, the second axis oriented at an angle less than 30 degrees relative to the first axis. The housing includes a plurality of baffles positioned between the microarray chip and the camera, and a plurality of laser beamstops to receive the excitation beam reflected off the microarray chip.

公开(公告)号：US20230338950A1

公开(公告)日：2023-10-26

申请号：US18042032

申请日：2021-08-20

Applicant: Duke University

Inventor： Ashutosh Chilkoti ,  David Kinnamon ,  Cassio Fontes ,  Angus Hucknall ,  Jason Liu ,  Jacob Heggestad

IPC: B01L3/00 ,  G01N33/543

CPC classification number: B01L3/502715 ,  G01N33/54366 ,  B01L2200/12 ,  B01L2200/16 ,  B01L2300/0887 ,  B01L2300/12 ,  B01L2400/0406 ,  B01L2400/0457

Abstract: Described herein is an assay device, comprising a substrate comprising microfluidic geometry, and a reagent layer disposed adjacent to the substrate.

公开(公告)号：US20220205917A1

公开(公告)日：2022-06-30

申请号：US17607761

申请日：2020-05-02

Applicant: Duke University

Inventor： Jason Liu ,  Ashutosh Chilkoti

IPC: G01N21/64

Abstract: A microarray chip imaging detector comprises a housing configured to receive a microarray chip. The detector includes a laser assembly supported by the housing and oriented at an angle relative to the microarray chip, the laser assembly configured to transmit an excitation beam along a first axis to samples on the microarray chip. The detector also includes a camera supported by the housing and positioned along a second axis, the camera configured to receive fluorescent light emitted from fluorophores in the samples on the microarray chip, the second axis oriented at an angle less than 30 degrees relative to the first axis. The housing includes a plurality of baffles positioned between the microarray chip and the camera, and a plurality of laser beamstops to receive the excitation beam reflected off the microarray chip.