公开(公告)号：US20230247276A1

公开(公告)日：2023-08-03

申请号：US18295078

申请日：2023-04-03

Applicant: DUKE UNIVERSITY

Inventor： Xi Yang ,  Pavan Chandra Konda ,  Roarke Horstmeyer ,  Clare Cook

IPC: H04N23/57 ,  H04N23/61 ,  H04N23/56 ,  H04N23/90 ,  H04N23/95 ,  G06T15/00 ,  G03B17/12 ,  G02B5/30 ,  G02B5/28

CPC classification number: H04N23/57 ,  H04N23/61 ,  H04N23/56 ,  H04N23/90 ,  H04N23/95 ,  G06T15/005 ,  G03B17/12 ,  G02B5/3025 ,  G02B5/28

Abstract: A microscopy system includes a planar array of micro-cameras with at least three micro-cameras of the planar array of micro-cameras each capturing a unique angular distribution of light reflected from a corresponding portion of a target area. The corresponding portions of the target area for the at least three micro-cameras contain an overlapping area of the target area. The microscopy system further includes a primary lens disposed in a path of the light between the planar array of micro-cameras and the target area. This microscopy system is capable of producing 3D imaging and/or video imaging of the target area. In some cases, the microscopy system is configured to generate a 3D image from the captured unique angular distribution of light reflected from the corresponding portions of the target area of the at least three micro-cameras of the planar array of micro-cameras.

公开(公告)号：US12288158B2

公开(公告)日：2025-04-29

申请号：US17830058

申请日：2022-06-01

Applicant: Duke University

Inventor： Pratik Bokadia ,  Amey Chaware ,  Roarke Horstmeyer ,  Kanghyun Kim ,  Pavan Konda

IPC: G06N3/08 ,  G02B21/06 ,  G02B21/36 ,  G06V10/143 ,  G06V10/145 ,  G06V10/82 ,  G06V20/69

Abstract: The present disclosure describes a computational imaging system that uses a supervised learning algorithm to jointly process the captured image data to identify task-optimal hardware settings and then uses the task-optimal hardware settings to dynamically adjust its hardware to improve specific performance. The primary application of this device is for rapid and accurate automatic analysis of images of biological specimens.

公开(公告)号：US12259541B2

公开(公告)日：2025-03-25

申请号：US17675538

申请日：2022-02-18

Applicant: DUKE UNIVERSITY

Inventor： Xi Yang ,  Pavan Chandra Konda ,  Roarke Horstmeyer

IPC: G02B21/36 ,  H04N23/45

Abstract: A microscopy system includes a primary lens and a planar array of micro-cameras. Each micro-camera of the planar array of micro-cameras has a field of view at an intermediate plane that overlaps at least one other micro-camera's field of view at the intermediate plane in a direction. The primary lens is disposed in a light path between the array of micro-cameras and a target area. In some cases, an overlap amount in the direction of the field of view at the intermediate plane for each micro-camera is at least 50%. A method of microscopy imaging includes directing light to a target area and simultaneously capturing a first set of images of the target area while the light illuminates the target area via a planar array of micro-cameras having a field of view at an intermediate plane disposed between a primary lens and the planar array of micro-cameras.

公开(公告)号：US20240406583A1

公开(公告)日：2024-12-05

申请号：US18677131

申请日：2024-05-29

Applicant: Duke University

Inventor： Roarke Horstmeyer ,  Shiqi Xu ,  Xiang Dai ,  Lucas Kreiss ,  Jadee Neff ,  Carolyn Glass

IPC: H04N23/951 ,  G02B21/06 ,  G02B21/36 ,  G06T5/10 ,  G06T5/50

Abstract: A Fourier ptychography system includes a polarization-sensitive camera positioned for capturing a sequence of polarized images of a sample, an objective lens positioned in a light path between the polarization-sensitive camera and the sample, an array of light sources for directing light to the sample and a generator polarizer positioned between the array of light sources and the sample to polarize light directed to the sample from the array of light sources. A method of creating a tomographic Fourier ptychography image includes receiving, from a polarization-sensitive camera, a sequence of polarized images of a sample, stitching each image of the sequence of images together using a non-linear Fourier transform function to create a composite image, and outputting the composite image as the tomographic Fourier ptychography image. Each polarized image of the sequence of polarized images overlaps another polarized image of the sequence of polarized images.

公开(公告)号：US20220260823A1

公开(公告)日：2022-08-18

申请号：US17675538

申请日：2022-02-18

Applicant: DUKE UNIVERSITY

Inventor： Xi Yang ,  Pavan Chandra Konda ,  Roarke Horstmeyer

IPC: G02B21/36 ,  H04N5/225

Abstract: A microscopy system includes a primary lens and a planar array of micro-cameras. Each micro-camera of the planar array of micro-cameras has a field of view at an intermediate plane that overlaps at least one other micro-camera's field of view at the intermediate plane in a direction. The primary lens is disposed in a light path between the array of micro-cameras and a target area. In some cases, an overlap amount in the direction of the field of view at the intermediate plane for each micro-camera is at least 50%. A method of microscopy imaging includes directing light to a target area and simultaneously capturing a first set of images of the target area while the light illuminates the target area via a planar array of micro-cameras having a field of view at an intermediate plane disposed between a primary lens and the planar array of micro-cameras.

公开(公告)号：US20220188996A1

公开(公告)日：2022-06-16

申请号：US17547731

申请日：2021-12-10

Applicant: DUKE UNIVERSITY ,  RAMONA OPTICS INC.

Inventor： Kevin Zhou ,  Colin Cooke ,  Jaehee Park ,  Ruobing Qian ,  Roarke Horstmeyer ,  Joseph Izatt ,  Sina Farsiu

IPC: G06T5/50 ,  G06T5/00

Abstract: A method of mesoscopic photogrammetry can be carried out using a set of images captured from a camera on a mobile computing device. Upon receiving the set of images, the method generates a composite image, which can include applying homographic rectification to warp all images of the set of images onto a common plane; applying a rectification model to undo perspective distortion in each image of the set of images; and applying an undistortion model for adjusting for camera imperfections of a camera that captured each image of the set of images. A height map is generated co-registered with the composite image, for example, by using an untrained CNN whose weights/parameters are optimized in order to optimize the height map. The height map and the composite image can be output for display.