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    Method to design temporal patterns of nervous system stimulation
    1.
    发明授权
    Method to design temporal patterns of nervous system stimulation 有权

    公开(公告)号：US11351378B2

    公开(公告)日：2022-06-07

    申请号：US16472466

    申请日：2017-12-21

    Applicant: DUKE UNIVERSITY

    Inventor： Warren M. Grill ,  David T. Brocker ,  Alexander R. Kent

    IPC: A61N1/36 ,  G16H20/30 ,  G16H50/50 ,  G16B5/20

    Abstract: The present invention relates to methods that enable one to design temporal patterns for the optimal stimulation of a nervous system, one or more nerve cells, or nervous tissue. In one embodiment, the present invention relates to methods to design improved stimulation patterns and/or genetic algorithms for the optimal stimulation of a nervous system, one or more nerve cells, or nervous tissue. In one embodiment, the present invention utilizes a model-based design to achieve a more optimal stimulation pattern for use in connection with a nervous system, one or more nerve cells, or nervous tissue (e.g., a human nervous system). In another embodiment, the model-based design of the present invention utilizes a systematic search method to identify parameters (e.g., design variables) that minimize a cost function (e.g., optimize the fitness of a particular design). In one instance, the system and method of the present invention is demonstrated via optimal temporal patterns of electrical stimulation for a nervous system, one or more nerve cells, or nervous tissue.

    SYSTEMS AND METHODS FOR DETERMINING OPTIMAL TEMPORAL PATTERNS OF NEURAL STIMULATION
    2.
    发明申请
    SYSTEMS AND METHODS FOR DETERMINING OPTIMAL TEMPORAL PATTERNS OF NEURAL STIMULATION 有权

    公开(公告)号：US20210322775A1

    公开(公告)日：2021-10-21

    申请号：US17355092

    申请日：2021-06-22

    Applicant: Duke University

    Inventor： Warren M. Grill ,  Isaac Cassar ,  Nathan Titus

    IPC: A61N1/36 ,  G16H20/40 ,  G16H50/50 ,  A61N1/02 ,  A61N1/372

    Abstract: Systems and methods for determining optimal temporal patterns of neural stimulation are disclosed. According to an aspect, a method includes selecting a temporal pattern for neural stimulation. The method also includes determining a mutation type for altering a pattern of pulses of the temporal pattern. The method also includes identifying a location within the pattern of pulses of the temporal pattern to alter based on the determined mutation type. The method further includes altering the pattern of pulses of the temporal pattern based on the identified location and mutation type for application of the altered temporal pattern to a subject.

    Systems and methods for utilizing model-based optimization of spinal cord stimulation parameters
    3.
    发明授权
    Systems and methods for utilizing model-based optimization of spinal cord stimulation parameters 有权

    公开(公告)号：US10576271B2

    公开(公告)日：2020-03-03

    申请号：US15845127

    申请日：2017-12-18

    Applicant: Duke University

    Inventor： Warren M. Grill ,  Bryan Howell ,  Shivanand P. Lad

    IPC: A61N1/05 ,  A61N1/36 ,  G16H20/30 ,  G16H50/50

    Abstract: Systems, methods, and devices are disclosed for optimizing patient-specific stimulation parameters for spinal cord stimulation. A patient-specific anatomical model is developed based on a pre-operative image, and a patient-specific electrical model is developed based on the anatomical model. The inputs to the electric model are chosen, and the model is used to calculate a distribution of electrical potentials within the modeled domain. Models of neural elements are stimulated with the electric potentials and used to determine which elements are directly activated by the stimulus. Information about the models inputs and which neural elements are active is applied to a cost function. Based on the value of the cost function, the inputs to the optimization process may be adjusted. Inputs to the optimization process include lead/electrode array geometry, lead configuration, lead positions, and lead signal characteristics, such as pulse width, amplitude, frequency and polarity.

    Systems and methods for model-based optimization of spinal cord stimulation electrodes and devices
    5.
    发明授权
    Systems and methods for model-based optimization of spinal cord stimulation electrodes and devices 有权

    公开(公告)号：US10096386B2

    公开(公告)日：2018-10-09

    申请号：US15321801

    申请日：2015-07-01

    Applicant: Duke University

    Inventor： Warren M. Grill ,  Bryan Howell

    IPC: G06F19/00 ,  G16H50/50 ,  G06F17/13 ,  A61N1/05 ,  A61N1/36 ,  A61N1/372

    Abstract: Systems and methods for model-based optimization of spinal cord stimulation electrodes and devices are disclosed. According to an aspect a method includes providing a patient-specific electroanatomical model including the spine, spinal cord, and a map of target neural elements and non-target neural elements. The method also includes using model electrodes to stimulate the target neural elements. Further, the method includes determining differences in activation thresholds between the target neural elements and the non-target neural elements in a plurality of different configurations of the model electrodes. The method also includes generating an optimal spinal cord stimulation electrode configuration based on the determined differences in activation thresholds.

    Non-regular electrical stimulation patterns designed with a cost function for treating neurological disorders
    9.
    发明授权
    Non-regular electrical stimulation patterns designed with a cost function for treating neurological disorders 有权
    设计具有用于治疗神经障碍的成本函数的非常规电刺激模式

    公开(公告)号：US09572988B2

    公开(公告)日：2017-02-21

    申请号：US15005636

    申请日：2016-01-25

    Applicant: Duke University

    Inventor： Warren M. Grill ,  David T. Brocker

    IPC: A61N1/08 ,  A61N1/36 ,  A61N1/05

    CPC classification number: A61N1/36178 ,  A61N1/0534 ,  A61N1/36067 ,  A61N1/36082 ,  A61N1/36125 ,  A61N1/36128 ,  A61N1/36196

    Abstract: Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.

    Abstract translation: 用于刺激神经组织的系统和方法产生具有刺激时间模式的刺激训练，其中电脉冲之间的间隔（脉冲间间隔）随时间变化或变化。 与具有规则（即恒定）脉冲间间隔的常规连续高速脉冲串相比，体现本发明特征的非规则（即，不是恒定的）脉冲模式或火车提供较低的平均频率。

    SPATIALLY SELECTIVE VAGUS NERVE STIMULATION
    10.
    发明申请
    SPATIALLY SELECTIVE VAGUS NERVE STIMULATION 审中-公开
    空间选择性VAGUS神经刺激

    公开(公告)号：US20130310893A1

    公开(公告)日：2013-11-21

    申请号：US13954959

    申请日：2013-07-30

    Applicant: Duke University ,  Cardiac Pacemakers, Inc.

    Inventor： Paul B. Yoo ,  Warren M. Grill ,  Juan Gabriel Hincapie Ordonez

    IPC: A61N1/36

    CPC classification number: A61N1/36053 ,  A61B5/04001 ,  A61B5/0488 ,  A61B5/4029 ,  A61N1/0556 ,  A61N1/36114 ,  A61N1/36167

    Abstract: By targeting on selected branches or fascicles of a vagus nerve using electrode placement and/or selection, one or more target branches of the vagus nerve are substantially activated by electrical stimulation pulses delivered to a branch without substantially activating one or more non-target branches. In one embodiment, vagus nerve stimulation is delivered through an electrode placed on a thoracic vagus nerve that is separated from a recurrent laryngeal nerve, such that the vagus nerve is stimulated without causing laryngeal muscle contractions. In another embodiment, vagus nerve stimulation is delivered through a multi-contact electrode with one or more contacts selected for delivering the electrical stimulation pulses to stimulate the vagus nerve without causing laryngeal muscle contractions.

    Abstract translation: 通过使用电极放置和/或选择来靶向迷走神经的选定分支或分支，迷走神经的一个或多个目标分支基本上被传递到分支的电刺激脉冲激活，而基本上不激活一个或多个非目标分支。 在一个实施例中，迷走神经刺激通过放置在与复发性喉部神经分离的胸部迷走神经上的电极递送，使得迷走神经被刺激而不引起喉部肌肉收缩。 在另一个实施方案中，迷走神经刺激通过多接触电极递送，其中一个或多个触点被选择用于递送电刺激脉冲以刺激迷走神经而不引起喉部肌肉收缩。

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