-
1.发明申请公开(公告)号：US20240366792A1
公开(公告)日：2024-11-07
申请号：US18649798
申请日：2024-04-29
Applicant: Duke University , Cold Spring Harbor Laboratory
Inventor： Z. Josh Huang , Yongjun Qian
Abstract: A readrRNA (RNA sensing by Endogenous ADAR) molecule is a modular RNA molecule that facilitates cell sensing and detection of a cell type or cell status and/or facilitates delivery of an effector protein to a selected cell. A composition that includes such a modular RNA molecule and another nucleic acid (linked or unlinked to the modular RNA molecule) is a CellREADR (Cell access through RNA sensing by Endogenous ADAR). readrRNA and CellReadR sense the presence of a selected cell RNA and leverages RNA editing mediated by ADAR (adenosine deaminase acting on RNA) for coupling the detection of a cell-defining RNA with translation of one or more effector proteins in a cell or in a mammal.
-
2.发明申请公开(公告)号：US20250011765A1
公开(公告)日：2025-01-09
申请号：US18649873
申请日：2024-04-29
Applicant: Duke University , Cold Spring Harbor Laboratory
Inventor： Z. Josh Huang , Yongjun Qian
Abstract: A readrRNA (RNA sensing by Endogenous ADAR) molecule is a modular RNA molecule that facilitates sensing and detection of a cell type or cell status of a cell, including a cell of a mammalian nervous system, such as a neuronal or non-neuronal cell of the mammalian central and/or peripheral nervous system, and/or facilitates delivery of an effector protein to the selected cell. A composition that includes such a modular RNA molecule and another nucleic acid (linked or unlinked to the modular RNA molecule) is a CellREADR (Cell access through RNA sensing by Endogenous ADAR). CellREADR senses the presence of a selected cell RNA in a cell of a mammalian nervous system via readrRNA and leverages RNA editing mediated by ADAR (adenosine deaminase acting on RNA) for coupling the detection of a cell-defining RNA with translation of one or more effector proteins in a cell of a mammalian nervous system.
-
Search Results
2
records
(took 0.014 seconds)
